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Sirano Dhe-Paganon

Sirano Dhe-Paganon

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
16966
World Ranking
9076
National Ranking
4032

Overview

Sirano Dhe-Paganon is affiliated with Harvard University in the United States. Their research spans multiple fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, with significant work also in Medicine.

The scientist's main subfields of study include Molecular Biology, Infectious Diseases, Oncology, Immunology, and Cell Biology. Within these areas, Sirano Dhe-Paganon addresses topics such as Ubiquitin and proteasome pathways, Protein degradation and inhibitors, Peptidase inhibition and analysis, SARS-CoV-2 and COVID-19 research, signaling pathways in disease, cancer-related gene regulation, and RNA modifications in cancer.

Their publication record shows frequent contributions in notable venues including bioRxiv (Cold Spring Harbor Laboratory), Cell Chemical Biology, Blood, Nature Chemical Biology, and Cell.

Some of the recent papers authored or co-authored by Sirano Dhe-Paganon are:

  • Lactate regulates cell cycle by remodelling the anaphase promoting complex (2023, Nature)
  • Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease (2023, Nature Medicine)
  • An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity (2022, Cell)
  • Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo (2021, Nature Chemical Biology)
  • Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism (2020, Scientific Reports)

Frequent co-authors collaborating with Sirano Dhe-Paganon include Hyuk-Soo Seo, Kijun Song, Jarrod A. Marto, Ezekiel A. Geffken, and Etsuro Nanishi.

Best Publications

  • Phthalimide conjugation as a strategy for in vivo target protein degradation

    Georg E. Winter;Dennis L. Buckley;Joshiawa Paulk;Justin M. Roberts

  • Crystal Structure of the Tyrosine Phosphatase SHP-2

    Peter Hof;Scott Pluskey;Sirano Dhe-Paganon;Michael J Eck

  • Protein production and purification.

    S Gräslund

  • Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

    George V. Avvakumov;John R. Walker;Sheng Xue;Yanjun Li

  • Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

    Michael J. Eck;Michael J. Eck;Sirano Dhe-Paganon;Sirano Dhe-Paganon;Thomas Trüb;Thomas Trüb;Robert T. Nolte;Robert T. Nolte

  • FKBP Family Proteins: Immunophilins with Versatile Biological Functions

    Cong Bao Kang;Ye Hong;Sirano Dhe-Paganon;Ho Sup Yoon

  • A strategy for modulation of enzymes in the ubiquitin system.

    Andreas Ernst;George Avvakumov;Jiefei Tong;Yihui Fan

  • Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

    Tara L Davis;John R Walker;Valérie Campagna-Slater;Patrick J Finerty

  • Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

    Dante Neculai;Michael Schwake;Michael Schwake;Mani Ravichandran;Friederike Zunke

  • Architecture of Eph receptor clusters.

    Juha P. Himanen;Laila Yermekbayeva;Peter W. Janes;John R. Walker

  • Crystal structure of the HNF4α ligand binding domain in complex with endogenous fatty acid ligand

    Sirano Dhe-Paganon;Karen Duda;Melanie Iwamoto;Young In Chi

  • Transcription control by the ENL YEATS domain in acute leukaemia

    Michael A. Erb;Thomas G. Scott;Bin E. Li;Huafeng Xie;Huafeng Xie

  • In situ proteolysis for protein crystallization and structure determination

    Aiping Dong;Xiaohui Xu;Aled M. Edwards;Changsoo Chang

  • Structure of the globular tail of nuclear lamin

    Sirano Dhe-Paganon;Eric D. Werner;Young In Chi;Steven E. Shoelson

  • Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

    Dongsheng Cai;Sirano Dhe-Paganon;Peter A. Melendez;Jongsoon Lee

  • Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

    David Remillard;Dennis L. Buckley;Joshiawa Paulk;Gerard L. Brien

  • An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme

    Derek F. Ceccarelli;Xiaojing Tang;Benoit Pelletier;Stephen Orlicky

  • Crystal Structure of Human Frataxin

    Sirano Dhe-Paganon;Ron Shigeta;Young-In Chi;Michael Ristow

  • Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

    Hui Ouyang;Yousuf O. Ali;Mani Ravichandran;Aiping Dong

  • Transcription control by the ENL YEATS domain in acute leukemia

    M. Erb;G. Winter;S. Dastjerdi;T. Scott

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Jarrod A. Marto
Jarrod A. Marto Harvard University
James E. Bradner
James E. Bradner Amgen (United States)
Nathanael S. Gray
Nathanael S. Gray Stanford University
Scott B. Ficarro
Scott B. Ficarro Harvard University
Steven E. Shoelson
Steven E. Shoelson Harvard University
Karl Gruber
Karl Gruber University of Graz
Michael J. Eck
Michael J. Eck Harvard University
Tinghu Zhang
Tinghu Zhang Stanford University
Loren D. Walensky
Loren D. Walensky Harvard University

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