Cheryl H. Arrowsmith

Research.com Recognitions

• 2025 - Research.com Best Female Scientists Award
• 2023 - Research.com Biology and Biochemistry in Canada Leader Award
• 2022 - Research.com Biology and Biochemistry in Canada Leader Award
• 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Histone recognition and large-scale structural analysis of the human bromodomain family.

  Panagis Filippakopoulos;Sarah Picaud;Maria Mangos;Tracy Keates

  1685
  Citations

• Epigenetic protein families: a new frontier for drug discovery

  Cheryl H. Arrowsmith;Chas Bountra;Paul V. Fish;Kevin Lee;Kevin Lee

  1486
  Citations

• Protein production and purification.

  S Gräslund

  1004
  Citations

• Consistent blind protein structure generation from NMR chemical shift data

  Yang Shen;Oliver Lange;Frank Delaglio;Paolo Rossi

  949
  Citations

• The promise and peril of chemical probes.

  Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  883
  Citations

• Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

  Masoud Vedadi;Frank H. Niesen;Abdellah Allali-Hassani;Oleg Y. Fedorov

  731
  Citations

• Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

  Ling Huang;Audrey Holtzinger;Ishaan Jagan;Michael Begora

  704
  Citations

• Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

  Damian B. Yap;Damian B. Yap;Justin Chu;Tobias Berg;Matthieu Schapira

  682
  Citations

• A Suite of Triple Resonance NMR Experiments for the Backbone Assignment of 15N, 13C, 2H Labeled Proteins with High Sensitivity

  Toshio Yamazaki;Weontae Lee;Cheryl H. Arrowsmith;D. R. Muhandiram

  671
  Citations

• A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

  Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  608
  Citations

• Self-renewal as a therapeutic target in human colorectal cancer

  Antonija Kreso;Peter van Galen;Nicholas M Pedley;Evelyne Lima-Fernandes

  542
  Citations

• ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

  Homayoun Vaziri;Michael D. West;Richard C. Allsopp;Timothy S. Davison

  521
  Citations

• Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

  George V. Avvakumov;John R. Walker;Sheng Xue;Yanjun Li

  521
  Citations

• Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

  Jiajun Zhu;Morgan A. Sammons;Greg Donahue;Zhixun Dou

  490
  Citations

• Global analysis of protein folding using massively parallel design, synthesis, and testing

  Gabriel J. Rocklin;Tamuka M. Chidyausiku;Inna Goreshnik;Alex Ford

  478
  Citations

• An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

  Kyle D. Konze;Anqi Ma;Fengling Li;Dalia Barsyte-Lovejoy

  477
  Citations

• Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

  Vivian Saridakis;Yi Sheng;Feroz Sarkari;Melissa N. Holowaty

  436
  Citations

• Structural proteomics of an archaeon.

  Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger

  417
  Citations

• Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

  Xiaoyang Lan;David J. Jörg;Florence M. G. Cavalli;Laura M. Richards;Laura M. Richards

  392
  Citations

• Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

  Scott B Rothbart;Krzysztof Krajewski;Nataliya Nady;Wolfram Tempel

  381
  Citations