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Chemistry

D-Index
63
Citations
15531
World Ranking
8356
National Ranking
2413

Overview

Thomas Szyperski is affiliated with the University at Buffalo, State University of New York in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and chemistry, with a focus on molecular biology, spectroscopy, materials chemistry, organic chemistry, and ecology as subfields.

The main topics of their work include:

  • Protein structure and dynamics
  • Enzyme structure and function
  • Molecular sensors and ion detection
  • RNA and protein synthesis mechanisms
  • DNA and nucleic acid chemistry
  • Lipid membrane structure and behavior
  • Chemical reaction mechanisms

Szyperski has contributed to several recent publications, including:

  • "Perturbing the energy landscape for improved packing during computational protein design" (2020), published in Proteins Structure Function and Bioinformatics
  • "Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes" (2023), published in Nature Chemistry
  • "Anion-binding aromatic pentaamide macrocycles: Synthesis, high-affinity binding, transmembrane transport, and catalysis" (2022), published in Research Square (Research Square)
  • "Computational de novo design of a four-helix bundle protein - DND-4HB" (2020), published by UNC Libraries
  • "Hanudatta S. Atreya (1974-2020)" (2021), published in Magnetic Resonance in Chemistry

Their work has been published across a variety of venues, with multiple contributions to:

  • UNC Libraries
  • Proteins Structure Function and Bioinformatics
  • Nature Chemistry
  • Research Square (Research Square)
  • Magnetic Resonance in Chemistry

Szyperski frequently collaborates with several researchers, including:

  • Brian Kuhlman
  • Mischa Machius
  • Ruikai Cao
  • Robert B. Rossdeutcher
  • Yulong Zhong

Best Publications

  • Consistent blind protein structure generation from NMR chemical shift data

    Yang Shen;Oliver Lange;Frank Delaglio;Paolo Rossi

  • Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling.

    Dario Neri;Thomas Szyperski;Gottfried Otting;Hans Senn

  • Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism.

    Thomas Szyperski

  • GFT NMR, a new approach to rapidly obtain precise high-dimensional NMR spectral information

    Seho Kim;Thomas Szyperski

  • Accurate de novo design of hyperstable constrained peptides.

    Gaurav Bhardwaj;Vikram Khipple Mulligan;Christopher D. Bahl;Jason M. Gilmore

  • Biosynthetically Directed Fractional 13C-labeling of Proteinogenic Amino Acids

    Thomas Szyperski

  • Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism.

    Uwe Sauer;Daniel R. Lasko;Jocelyne Fiaux;Michel Hochuli

  • NMR scalar couplings across Watson-Crick base pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy

    Konstantin Pervushin;Akira Ono;César Fernández;Thomas Szyperski

  • Metabolic Flux Responses to Pyruvate Kinase Knockout in Escherichia coli

    Marcel Emmerling;Michael Dauner;Aaron Ponti;Jocelyne Fiaux

  • Metabolic fluxes in riboflavin-producing Bacillus subtilis

    Uwe Sauer;Vassily Hatzimanikatis;James E. Bailey;Michel Hochuli

  • 13C-NMR, MS and metabolic flux balancing in biotechnology research

    Thomas Szyperski

  • NMR Structure Determination for Larger Proteins Using Backbone-Only Data

    Srivatsan Raman;Oliver F. Lange;Paolo Rossi;Michael Tyka

  • Protein NMR spectroscopy in structural genomics.

    Gaetano T. Montelione;Deyou Zheng;Yuanpeng J. Huang;Kristin C. Gunsalus

  • Metabolic flux response to phosphoglucose isomerase knock-out in Escherichia coli and impact of overexpression of the soluble transhydrogenase UdhA.

    Fabrizio Canonaco;Tracy A. Hess;Sylvia Heri;Taotao Wang

  • The NMR structure of the pulmonary surfactant-associated polypeptide SP-C in an apolar solvent contains a valyl-rich alpha-helix.

    J Johansson;T Szyperski;T Curstedt;K. Wuthrich

  • NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone

    Maurizio Pellecchia;Thomas Szyperski;Daniel Wall;Costa Georgopoulos

  • Determination of scalar coupling constants by inverse Fourier transformation of in-phase multiplets

    T Szyperski;P Güntert;G Otting;K Wüthrich

  • Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids

    Hannu Maaheimo;Jocelyne Fiaux;Z. Petek Çakar;James E. Bailey

  • Metabolic-Flux Profiling of the Yeasts Saccharomyces cerevisiae and Pichia stipitis

    Jocelyne Fiaux;Z. Petek Çakar;Marco Sonderegger;Kurt Wüthrich

  • NMR solution structure of the pathogenesis-related protein P14a.

    César Fernández;Thomas Szyperski;Thierry Bruyère;Paul Ramage

  • NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.

    Thomas Szyperski;Maurizio Pellecchia;Daniel Wall;Daniel Wall;Costa Georgopoulos

Frequent Co-Authors

Gaetano T. Montelione
Gaetano T. Montelione Rensselaer Polytechnic Institute
Rong Xiao
Rong Xiao Rutgers, The State University of New Jersey
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
James H. Prestegard
James H. Prestegard University of Georgia
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Jinfeng Liu
Jinfeng Liu Genentech
Burkhard Rost
Burkhard Rost Technical University of Munich
David Baker
David Baker University of Washington
Barry Honig
Barry Honig Columbia University
Uwe Sauer
Uwe Sauer ETH Zurich

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