World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
130
Citations
72546
World Ranking
318
National Ranking
148

Biology and Biochemistry

D-Index
137
Citations
80032
World Ranking
323
National Ranking
217

Research.com Recognitions

  • 2007 - Fellow of the American Academy of Arts and Sciences
  • 2006 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Member of the National Academy of Sciences

Overview

Barry Honig is affiliated with Columbia University in the United States and has made significant contributions in the field of Biochemistry, Genetics, and Molecular Biology. Their research predominantly focuses on Molecular Biology, with additional work in Cell Biology, Cellular and Molecular Neuroscience, Computational Theory and Mathematics, and Ecology.

The scientist's main topics of work include:

  • Protein Structure and Dynamics
  • Bioinformatics and Genomic Networks
  • Microbial Metabolic Engineering and Bioproduction
  • Computational Drug Discovery Methods
  • Wnt/β-catenin signaling in development and cancer
  • Neurobiology and Insect Physiology Research
  • Axon Guidance and Neuronal Signaling

Barry Honig has authored numerous research papers, some of the recent publications include:

  • Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition (2020, Cell)
  • Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function (2021, Cell Reports)
  • Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins (2020, Cell Reports)
  • Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism (2023, Nature Cancer)
  • A Sweep of Earth's Virome Reveals Host-Guided Viral Protein Structural Mimicry and Points to Determinants of Human Disease (2020, Cell Systems)

Frequent collaborators in their research include Lawrence Shapiro, Phinikoula S. Katsamba, Diana Murray, Alina P. Sergeeva, and Seetha Mannepalli.

Their publications appear often in respected venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Journal of Molecular Biology
  • Proceedings of the National Academy of Sciences
  • Nature Communications

Barry Honig's career has been recognized with several honors, including:

  • Member of the National Academy of Sciences (2004)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2006)
  • Fellow of the American Academy of Arts and Sciences (2007)

Best Publications

  • Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.

    Anthony Nicholls;Kim A. Sharp;Barry Honig

  • Classical Electrostatics in Biology and Chemistry

    Barry Honig;Anthony Nicholls

  • A hierarchical approach to all-atom protein loop prediction.

    Matthew P. Jacobson;David L. Pincus;Chaya S. Rapp;Tyler J.F. Day

  • Accurate Calculation of Hydration Free Energies Using Macroscopic Solvent Models

    Doree Sitkoff;Kim A. Sharp;Barry Honig

  • Electrostatic interactions in macromolecules : theory and applications

    Kim A. Sharp;Barry Honig

  • The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.

    R E Tanzi;K Petrukhin;I Chernov;J L Pellequer

  • A rapid finite difference algorithm, utilizing successive over-relaxation to solve the Poisson-Boltzmann equation

    Anthony Nicholls;Barry Honig

  • Calculating the electrostatic potential of molecules in solution: Method and error assessment

    Michael K. Gilson;Kim A. Sharp;Barry H. Honig

  • On the role of the crystal environment in determining protein side-chain conformations.

    Matthew P. Jacobson;Richard A. Friesner;Zhexin Xiang;Barry Honig

  • The role of DNA shape in protein–DNA recognition

    Remo Rohs;Sean M. West;Alona Sosinsky;Alona Sosinsky;Peng Liu

  • Accurate First Principles Calculation of Molecular Charge Distributions and Solvation Energies from Ab Initio Quantum Mechanics and Continuum Dielectric Theory

    David J. Tannor;Bryan Marten;Robert Murphy;Richard A. Friesner

  • New Model for Calculation of Solvation Free Energies: Correction of Self-Consistent Reaction Field Continuum Dielectric Theory for Short-Range Hydrogen-Bonding Effects

    Bryan Marten;Kyungsun Kim;Christian Cortis,‖,⊥ and;Richard A. Friesner

  • Origins of Specificity in Protein-DNA Recognition

    Remo Rohs;Xiangshu Jin;Sean M. West;Rohit Joshi

  • Calculation of the total electrostatic energy of a macromolecular system: Solvation energies, binding energies, and conformational analysis

    Michael K. Gilson;Barry Honig

  • Rapid grid-based construction of the molecular surface and the use of induced surface charge to calculate reaction field energies: applications to the molecular systems and geometric objects.

    Walter Rocchia;Sundaram Sridharan;Anthony Nicholls;Emil Alexov

  • Extending the Applicability of the Nonlinear Poisson−Boltzmann Equation: Multiple Dielectric Constants and Multivalent Ions†

    W. Rocchia;and E. Alexov;B. Honig

  • Focusing of electric fields in the active site of Cu‐Zn superoxide dismutase: Effects of ionic strength and amino‐acid modification

    Isaac Klapper;Ray Hagstrom;Richard Fine;Kim Sharp

  • Electrostatic aspects of protein-protein interactions.

    Felix B Sheinerman;Raquel Norel;Barry Honig

  • Structure-based prediction of protein–protein interactions on a genome-wide scale

    Qiangfeng Cliff Zhang;Donald Petrey;Donald Petrey;Lei Deng;Lei Deng;Li Qiang

  • Reevaluation of the Born model of ion hydration

    Alexander A. Rashin;Barry Honig

Frequent Co-Authors

Lawrence Shapiro
Lawrence Shapiro Columbia University
Kim A. Sharp
Kim A. Sharp University of Pennsylvania
Gaetano T. Montelione
Gaetano T. Montelione Rensselaer Polytechnic Institute
Thomas G. Ebrey
Thomas G. Ebrey University of Washington
Koji Nakanishi
Koji Nakanishi Columbia University
Rong Xiao
Rong Xiao Rutgers, The State University of New Jersey
Thomas Szyperski
Thomas Szyperski University at Buffalo, State University of New York
Andrea Califano
Andrea Califano Columbia University
Richard S. Mann
Richard S. Mann Columbia University
Remo Rohs
Remo Rohs University of Southern California

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