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Chemistry

D-Index
78
Citations
31770
World Ranking
3727
National Ranking
1189

Overview

Kim A. Sharp is affiliated with the University of Pennsylvania in the United States. Their scholarly activity spans prominently across Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Hematology, Statistical and Nonlinear Physics, Oncology, and Cancer Research.

Their research topics include:

  • Multiple Myeloma Research and Treatments
  • Cancer Genomics and Diagnostics
  • Single-cell and spatial transcriptomics
  • Acute Lymphoblastic Leukemia research
  • Protein Degradation and Inhibitors
  • Peptidase Inhibition and Analysis
  • Per- and polyfluoroalkyl substances research

Sharp has published several papers across various journals and platforms. Notable recent works include:

  • "Copy number evolution and its relationship with patient outcome-an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial," 2020, Leukemia
  • "Computational Graphics Software for Interactive Docking and Visualization of Ligand-Protein Complementarity," 2021, Journal of Chemical Information and Modeling
  • "Specific and potent inhibition of steroid hormone pre-receptor regulator AKR1C2 by perfluorooctanoic acid: Implications for androgen metabolism," 2024, The Journal of Steroid Biochemistry and Molecular Biology
  • "Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes," 2025, Diabetes
  • "Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients," 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with Sharp include:

  • Nicholas Denny
  • T.M. Penning
  • Alastair Smith
  • Catherine Chahrour
  • Natalina Elliott

Sharp's research has been published repeatedly in venues such as:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Leukemia
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Journal of Chemical Information and Modeling

Best Publications

  • Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.

    Anthony Nicholls;Kim A. Sharp;Barry Honig

  • Accurate Calculation of Hydration Free Energies Using Macroscopic Solvent Models

    Doree Sitkoff;Kim A. Sharp;Barry Honig

  • Electrostatic interactions in macromolecules : theory and applications

    Kim A. Sharp;Barry Honig

  • Calculating the electrostatic potential of molecules in solution: Method and error assessment

    Michael K. Gilson;Kim A. Sharp;Barry H. Honig

  • The maximal affinity of ligands

    I. D. Kuntz;K. Chen;K. A. Sharp;P. A. Kollman

  • Focusing of electric fields in the active site of Cu‐Zn superoxide dismutase: Effects of ionic strength and amino‐acid modification

    Isaac Klapper;Ray Hagstrom;Richard Fine;Kim Sharp

  • Reconciling the magnitude of the microscopic and macroscopic hydrophobic effects

    Kim A. Sharp;Anthony Nicholls;Richard F. Fine;Barry Honig

  • On the calculation of pKas in proteins

    An‐Suei Yang;M. R. Gunner;Rosemary Sampogna;Kim Sharp

  • Calculating total electrostatic energies with the nonlinear Poisson-Boltzmann equation

    Kim A. Sharp;Barry. Honig

  • Macroscopic Models of Aqueous Solutions: Biological and Chemical Applications

    Barry Honig;Kim Sharp;An Suei Yang

  • Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models.

    Kim A. Sharp;Anthony Nicholls;Richard Friedman;Barry Honig

  • HEAT CAPACITY IN PROTEINS

    Ninad V. Prabhu;Kim A. Sharp

  • Entropy—enthalpy compensation: Fact or artifact?

    Kim Sharp

  • Hydrogen bonding and the cryoprotective properties of glycerol/water mixtures.

    Jennifer L. Dashnau;Nathaniel V. Nucci;Kim A. Sharp;Jane M. Vanderkooi

  • The electrostatic potential of B-DNA.

    B. Jayaram;Kim A. Sharp;Barry Honig

  • Theory of the electrokinetic behavior of human erythrocytes

    S. Levine;M. Levine;K.A. Sharp;D.E. Brooks

  • Effect of the Protein Denaturants Urea and Guanidinium on Water Structure: A Structural and Thermodynamic Study

    Francesco Vanzi;Bhupinder Madan;Kim Sharp

  • Computer simulations of the diffusion of a substrate to an active site of an enzyme.

    K Sharp;R Fine;B Honig

  • Water structure changes induced by hydrophobic and polar solutes revealed by simulations and infrared spectroscopy

    Kim A. Sharp;Bhupinder Madan;Eric Manas;Jane M. Vanderkooi

  • Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function

    Kevin Chin;Kim A. Sharp;Barry Honig;Anna Marie Pyle;Anna Marie Pyle

Frequent Co-Authors

Barry Honig
Barry Honig Columbia University
Jane M. Vanderkooi
Jane M. Vanderkooi University of Pennsylvania
A. Joshua Wand
A. Joshua Wand University of Pennsylvania
Donald E. Brooks
Donald E. Brooks University of British Columbia
Richard A. Friedman
Richard A. Friedman Columbia University
Michael K. Gilson
Michael K. Gilson University of California, San Diego
Bhyravabhotla Jayaram
Bhyravabhotla Jayaram Indian Institute of Technology Delhi
Paul A. Janmey
Paul A. Janmey University of Pennsylvania
Anna Marie Pyle
Anna Marie Pyle Yale University
Sanat K. Kumar
Sanat K. Kumar Columbia University

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