2026 Matthew P. Jacobson: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	78	4459	4115	2166	1951	242	31174

Research.com Recognitions

2004 - Fellow of Alfred P. Sloan Foundation

Overview

Matthew P. Jacobson is affiliated with the University of California, San Francisco in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with an emphasis on molecular biology and neurology.

The main fields of study covered by their publications include:

Biochemistry, Genetics and Molecular Biology
Medicine

Within these broader fields, their subfields of study focus on:

Molecular Biology
Neurology
Physiology
Organic Chemistry
Biochemistry

Their work involves research on important biomedical topics as demonstrated by the main topics explored in their publications:

Parkinson's Disease Mechanisms and Treatments
Amyotrophic Lateral Sclerosis Research
Alzheimer's disease research and treatments
Eicosanoids and Hypertension Pharmacology
Fatty Acid Research and Health
Computational Drug Discovery Methods
Receptor Mechanisms and Signaling

Frequent coauthors collaborating with Matthew P. Jacobson include:

Chakrapani Kalyanaraman
Theodore R. Holman
Diego Garrido Ruiz
Lani F. Wu
Steven J. Altschuler

The primary publication venues for their research consist of:

bioRxiv (Cold Spring Harbor Laboratory)
Biochemistry
Molecular Neurodegeneration
Research Square (Research Square)
Nature

Among their recent papers are the following:

Gasdermin D pore structure reveals preferential release of mature interleukin-1, 2021, Nature
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, 2020, bioRxiv (Cold Spring Harbor Laboratory)
Structure-based discovery of nonopioid analgesics acting through the α _2A -adrenergic receptor, 2022, Science
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation, 2022, Biochemistry
Synthetic group A streptogramin antibiotics that overcome Vat resistance, 2020, Nature

Matthew P. Jacobson received recognition as a Fellow of the Alfred P. Sloan Foundation in 2004.

Best Publications

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

David E. Gordon;Gwendolyn M. Jang;Mehdi Bouhaddou;Jiewei Xu

5396
Citations
A hierarchical approach to all-atom protein loop prediction.

Matthew P. Jacobson;David L. Pincus;Chaya S. Rapp;Tyler J.F. Day

2663
Citations
Novel procedure for modeling ligand/receptor induced fit effects.

Woody Sherman;Tyler Day;Matthew P Jacobson;Richard A Friesner

2233
Citations
Dysregulated pH: a perfect storm for cancer progression.

Bradley A. Webb;Michael Chimenti;Matthew P. Jacobson;Diane L. Barber

2124
Citations
On the role of the crystal environment in determining protein side-chain conformations.

Matthew P. Jacobson;Richard A. Friesner;Zhexin Xiang;Barry Honig

1381
Citations
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks

Matthew J. Rardin;Wenjuan He;Yuya Nishida;John C. Newman

636
Citations
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

Taha Rezai;Bin Yu;Glenn L Millhauser;Matthew P Jacobson

565
Citations
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Tadahiro Shimazu;Matthew D. Hirschey;Lan Hua;Kristin E. Dittenhafer-Reed

503
Citations
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides.

Taha Rezai;Jonathan E. Bock;Mai V. Zhou;Chakrapani Kalyanaraman

437
Citations
Gasdermin D pore structure reveals preferential release of mature interleukin-1

Shiyu Xia;Shiyu Xia;Zhibin Zhang;Zhibin Zhang;Venkat Giri Magupalli;Venkat Giri Magupalli;Juan Lorenzo Pablo;Juan Lorenzo Pablo

421
Citations
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Tina R White;Chad M Renzelman;Arthur C Rand;Taha Rezai;Taha Rezai

406
Citations
A kinematic view of loop closure.

Evangelos A. Coutsias;Chaok Seok;Matthew P. Jacobson;Ken A. Dill

332
Citations
Intracellular pH Sensors: Design Principles and Functional Significance

Jyoti Srivastava;Diane L. Barber;Matthew P. Jacobson

297
Citations
Computer-aided antibody design.

Daisuke Kuroda;Hiroki Shirai;Matthew P. Jacobson;Haruki Nakamura

280
Citations
Molecular mechanics methods for predicting protein-ligand binding.

Niu Huang;Chakrapani Kalyanaraman;Katarzyna Bernacki;Matthew P. Jacobson

272
Citations
Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.

Shyam Krishnan;Rand M. Miller;Boxue Tian;R. Dyche Mullins

264
Citations
Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles.

Christopher L. McClendon;Gregory Friedland;David L. Mobley;Homeira Amirkhani

247
Citations
Rescoring docking hit lists for model cavity sites: predictions and experimental testing.

Alan P. Graves;Devleena M. Shivakumar;Sarah E. Boyce;Matthew P. Jacobson

233
Citations
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding.

Christian Frantz;Gabriela Barreiro;Laura Dominguez;Xiaoming Chen

226
Citations
Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

William M. Hewitt;Siegfried S. F. Leung;Cameron R. Pye;Alexandra R. Ponkey

220
Citations