John A. Gerlt

Research.com Recognitions

• 2007 - Fellow of the American Association for the Advancement of Science (AAAS)
• 1981 - Fellow of Alfred P. Sloan Foundation

Overview

Best Publications

• Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks.

  John A. Gerlt;Jason T. Bouvier;Daniel B. Davidson;Heidi J. Imker

  837
  Citations

• The Low Barrier Hydrogen Bond in Enzymatic Catalysis

  W. Wallace Cleland;Perry A. Frey;John A. Gerlt

  776
  Citations

• The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways.

  Rémi Zallot;Nils Oberg;John A. Gerlt

  766
  Citations

• Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

  John A. Gerlt;Patricia C. Babbitt

  659
  Citations

• An explanation for rapid enzyme-catalyzed proton abstraction from carbon acids: importance of late transition states in concerted mechanisms

  John Alan Gerlt;Paul G. Gassman

  512
  Citations

• Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters

  John A. Gerlt;Paul G. Gassman

  502
  Citations

• Understanding enzymic catalysis: the importance of short, strong hydrogen bonds.

  John A. Gerlt;Maurice M. Kreevoy;W.W. Cleland;Perry A. Frey

  467
  Citations

• The Enolase Superfamily: A General Strategy for Enzyme-Catalyzed Abstraction of the α-Protons of Carboxylic Acids†

  Patricia C. Babbitt;Miriam S. Hasson;Miriam S. Hasson;Joseph E. Wedekind;Joseph E. Wedekind;David R.J. Palmer

  435
  Citations

• Understanding Enzyme Superfamilies CHEMISTRY AS THE FUNDAMENTAL DETERMINANT IN THE EVOLUTION OF NEW CATALYTIC ACTIVITIES

  Patricia C. Babbitt;John A. Gerlt

  367
  Citations

• Evolution of enzyme superfamilies

  Margaret E Glasner;John A Gerlt;Patricia C Babbitt

  294
  Citations

• Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.

  Toomas Haller;Thomas Buckel;János Rétey;John A. Gerlt

  260
  Citations

• Understanding enzyme-catalyzed proton abstraction from carbon acids: Details of stepwise mechanisms for β-elimination reactions

  John A. Gerlt;Paul G. Gassman

  248
  Citations

• The Crystal Structure of Benzoylformate Decarboxylase at 1.6 Å Resolution: Diversity of Catalytic Residues in Thiamin Diphosphate-Dependent Enzymes†,‡

  Miriam S. Hasson;Angelika Muscate;Michael J. McLeish;Lena S. Polovnikova

  241
  Citations

• Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence-Function Space and Genome Context to Discover Novel Functions.

  John A. Gerlt

  240
  Citations

• Divergent evolution in the enolase superfamily: The interplay of mechanism and specificity

  John A. Gerlt;Patricia C. Babbitt;Ivan Rayment

  238
  Citations

• The crotonase superfamily: Divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters

  Hazel M. Holden;Matthew M. Benning;Toomas Haller;John A. Gerlt

  231
  Citations

• Evolutionary Potential of (β/α)8-Barrels: Functional Promiscuity Produced by Single Substitutions in the Enolase Superfamily†

  Dawn M Z Schmidt;Emily C. Mundorff;Michael Dojka;Ericka Bermudez

  228
  Citations

• Roles of small laccases from Streptomyces in lignin degradation.

  Sudipta Majumdar;Tiit Lukk;Jose O. Solbiati;Stefan Bauer

  226
  Citations

• Mechanism of the reaction catalyzed by acetoacetate decarboxylase. Importance of lysine 116 in determining the pKa of active-site lysine 115.

  Lane A. Highbarger;John A. Gerlt;George L. Kenyon

  224
  Citations

• Electrophilic catalysis can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions

  John Alan Gerlt;John W. Kozarich;George L. Kenyon;Paul G. Gassman

  223
  Citations

• Can sequence determine function

  John A Gerlt;Patricia C Babbitt

  218
  Citations