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D-Index
48
Citations
10295
World Ranking
6149
National Ranking
175

Overview

Jaap J. Plomp is affiliated with Leiden University Medical Center in the Netherlands. The research primarily spans the field of Medicine, with a strong emphasis on Neurology and related subfields such as Molecular Biology, Surgery, Infectious Diseases, and Biomedical Engineering.

The scientist's work addresses multiple main topics, including:

  • Myasthenia Gravis and Thymoma
  • Peripheral Neuropathies and Disorders
  • Muscle Physiology and Disorders
  • Autoimmune Neurological Disorders and Treatments
  • Salivary Gland Tumors Diagnosis and Treatment
  • Ion channel regulation and function
  • Antifungal resistance and susceptibility

Jaap J. Plomp has contributed to several recent research papers, notable examples include:

  • Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders, 2022, The Lancet Neurology
  • Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis, 2021, Proceedings of the National Academy of Sciences
  • Simvastatin Treatment Does Not Ameliorate Muscle Pathophysiology in a Mouse Model for Duchenne Muscular Dystrophy, 2020, Journal of Neuromuscular Diseases
  • A bioassay for neuromuscular junction-restricted complement activation by myasthenia gravis acetylcholine receptor antibodies, 2022, Journal of Neuroscience Methods
  • Development and characterization of agonistic antibodies targeting the Ig-like 1 domain of MuSK, 2023, Scientific Reports

Collaborations are a significant aspect of the scientist's work. Frequent co-authors include:

  • Maartje G. Huijbers
  • Jan J.G.M. Verschuuren
  • Dana L.E. Vergoossen
  • Silvère M. van der Maarel
  • Roy Augustinus

The research is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuromuscular Disorders
  • The Lancet Neurology
  • Proceedings of the National Academy of Sciences
  • Science Translational Medicine

Best Publications

  • Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

    M Verhage;A S Maia;J J Plomp;A B Brussaard

  • A Cacna1a Knockin Migraine Mouse Model with Increased Susceptibility to Cortical Spreading Depression

    Arn M.J.M van den Maagdenberg;Daniela Pietrobon;Tommaso Pizzorusso;Simon Kaja

  • Acquired neuromyotonia: evidence for autoantibodies directed against K+ channels of peripheral nerves.

    Paul Shillito;Peter C. Molenaar;Angela Vincent;Angela Vincent;Katherine Leys

  • Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice

    Gert Jansen;P.J.T.A. Groenen;D. Bächner;P.H.K. Jap

  • MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

    Maartje G. Huijbers;Wei Zhang;Rinse Klooster;Erik H. Niks

  • Monoclonal antibodies raised against Guillain-Barré syndrome–associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations

    Carl S. Goodyear;Graham M. O’Hanlon;Jaap J. Plomp;Eric R. Wagner

  • Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model.

    Susan K. Halstead;Femke M. P. Zitman;Peter D. Humphreys;Kay Greenshields

  • Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

    Rinse Klooster;Jaap J. Plomp;Maartje G. Huijbers;Maartje G. Huijbers;Erik H. Niks

  • Miller Fisher anti-GQ1b antibodies: alpha-latrotoxin-like effects on motor end plates.

    J. J. Plomp;P. C. Molenaar;G. M. O'hanlon;B. C. Jacobs

  • High cortical spreading depression susceptibility and migraine-associated symptoms in Ca(v)2.1 S218L mice.

    Arn M. J. M. van den Maagdenberg;Tommaso Pizzorusso;Simon Kaja;Nicole Terpolilli

  • Adaptation of quantal content to decreased postsynaptic sensitivity at single endplates in alpha-bungarotoxin-treated rats.

    J. J. Plomp;G. T. H. Van Kempen;P. C. Molenaar

  • Munc18-1 expression levels control synapse recovery by regulating readily releasable pool size

    Ruud F. G. Toonen;Keimpe Wierda;Keimpe Wierda;Michèle S. Sons;Heidi de Wit

  • Anti-GQ1b ganglioside antibodies mediate complement-dependent destruction of the motor nerve terminal

    Graham M. O'Hanlon;Jaap J. Plomp;Mahua Chakrabarti;Ian Morrison

  • Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy.

    Susan K Halstead;Graham M O'Hanlon;Peter D Humphreys;Deborah B Morrison

  • Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4

    Jan J.G.M. Verschuuren;Maartje G. Huijbers;Jaap J. Plomp;Erik H. Niks

  • The expanding field of IgG4-mediated neurological autoimmune disorders

    M. G. Huijbers;L. A. Querol;E. H. Niks;J. J. Plomp

  • Natural disease history of the D2-mdx mouse model for Duchenne muscular dystrophy

    Maaike van Putten;Kayleigh Putker;Maurice Overzier;W. A. Adamzek

  • Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy.

    John A. Goodfellow;Tyrone Bowes;Tyrone Bowes;Kazim A Sheikh;Masaaki Odaka;Masaaki Odaka

  • The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice

    Kay N. Greenshields;Susan K. Halstead;Femke M.P. Zitman;Simon Rinaldi

  • Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding☆

    BC Jacobs;GM O'Hanlon;RW Bullens;J Veitch

  • Complex Gangliosides at the Neuromuscular Junction Are Membrane Receptors for Autoantibodies and Botulinum Neurotoxin But Redundant for Normal Synaptic Function

    Roland W. M. Bullens;Graham M. O'Hanlon;Eric Wagner;Peter C. Molenaar

Frequent Co-Authors

Rune R. Frants
Rune R. Frants Leiden University
Michel D. Ferrari
Michel D. Ferrari Leiden University Medical Center
Arn M. J. M. van den Maagdenberg
Arn M. J. M. van den Maagdenberg Leiden University Medical Center
Annemieke Aartsma-Rus
Annemieke Aartsma-Rus Leiden University Medical Center
Silvère M. van der Maarel
Silvère M. van der Maarel Leiden University Medical Center
Angela Vincent
Angela Vincent University of Oxford
Tommaso Pizzorusso
Tommaso Pizzorusso University of Florence
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Arjen B. Brussaard
Arjen B. Brussaard Vrije Universiteit Amsterdam
Peter A. C. 't Hoen
Peter A. C. 't Hoen Radboud University

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