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Rik K. Wierenga

Rik K. Wierenga

D-Index & Metrics

Chemistry

D-Index
63
Citations
14441
World Ranking
8409
National Ranking
41

Overview

Rik K. Wierenga is affiliated with the University of Oulu in Finland and specializes in research within Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Materials Science.

Their research focuses primarily on areas such as Enzyme Structure and Function, Biochemical and Molecular Research, and Microbial Metabolic Engineering and Bioproduction. Other topics addressed in their work include Endoplasmic Reticulum Stress and Disease, Cancer-related gene regulation, Protein Structure and Dynamics, and Cancer, Hypoxia, and Metabolism.

Rik K. Wierenga has authored several notable papers, including:

  • IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition (2021), published in Acta Crystallographica Section D Structural Biology
  • Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H α2β2 tetramer (2022), published in Journal of Biological Chemistry
  • An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration (2023), published in Nature Communications
  • Insights into the stability and substrate specificity of the E. coli aerobic β-oxidation trifunctional enzyme complex (2020), published in Journal of Structural Biology
  • Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains (2021), published in Journal of Biological Chemistry

Their frequent co-authors include Subhadra Dalwani, Rajaram Venkatesan, M. Kristian Koski, Tiila-Riikka Kiema, and Werner Schmitz.

Publications by Wierenga commonly appear in the following venues:

  • Acta Crystallographica Section D Structural Biology
  • Journal of Biological Chemistry
  • Journal of Structural Biology
  • IUCrJ
  • bioRxiv (Cold Spring Harbor Laboratory)

Their work spans multiple scientific subfields with emphasis on Molecular Biology, Materials Chemistry, Cell Biology, Cancer Research, and Biotechnology.

Best Publications

  • Prediction of the Occurrence of the ADP-binding βαβ-fold in Proteins, Using an Amino Acid Sequence Fingerprint

    Rik K. Wierenga;Peter Terpstra;Wim G.J. Hol

  • Crystal structure of a Src-homology 3 (SH3) domain.

    Andrea Musacchio;Martin Noble;Richard Pauptit;Rik Wierenga

  • The TIM-barrel fold: a versatile framework for efficient enzymes

    R.K Wierenga

  • Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant

    Rik K. Wierenga;Wim G. J. Hol

  • Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

    Unknown

  • The biochemistry of peroxisomal β-oxidation in the yeast Saccharomyces cerevisiae

    J.Kalervo Hiltunen;Anu M. Mursula;Hanspeter Rottensteiner;Rik K. Wierenga

  • The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

    John C Williams;Albert Weijland;Stefania Gonfloni;Andy Thompson

  • Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-Å resolution

    D. M. F. van Aalten;B. Synstad;M. B. Brurberg;E. Hough

  • Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

    Martin E. M. Noble;Andrea Musacchio;Matti Saraste;Sara A. Courtneidge

  • Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes.

    Herman A. Schreuder;Peter A.J. Prick;Rik K. Wierenga;Gerrit Vriend

  • Comparison of the three-dimensional protein and nucleotide structure of the FAD-binding domain of p-hydroxybenzoate hydroxylase with the FAD- as well as NADPH-binding domains of glutathione reductase.

    Rik K. Wierenga;Jan Drenth;Georg E. Schulz;R. Huber

  • Triosephosphate isomerase: a highly evolved biocatalyst

    R. K. Wierenga;E. G. Kapetaniou;R. Venkatesan

  • Crystal structure of enoyl-coenzyme A (CoA) hydratase at 2.5 angstroms resolution: a spiral fold defines the CoA-binding pocket.

    C K Engel;M Mathieu;J P Zeelen;J K Hiltunen

  • The thiolase superfamily: condensing enzymes with diverse reaction specificities.

    Antti M. Haapalainen;Gitte Meriläinen;Rik K. Wierenga

  • Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.

    R.K. Wierenga;M.E.M. Noble;G. Vriend;S. Nauche

  • Triose-phosphate isomerase (TIM) of the psychrophilic bacterium Vibrio marinus. Kinetic and structural properties.

    Marco Alvarez;Johan Ph. Zeelen;Véronique Mainfroid;Françoise Rentier-Delrue

  • The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures.

    Dominique Maes;Johan P. Zeelen;Narmada Thanki;Nicola Beaucamp

  • The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src

    Stefania Gonfloni;John C. Williams;Katarina Hattula;Albert Weijland

  • Crystal structure of p-hydroxybenzoate hydroxylase

    Unknown

  • Insights into Src kinase functions: structural comparisons

    John C Williams;Rik K Wierenga;Matti Saraste

  • Design, creation, and characterization of a stable, monomeric triosephosphate isomerase.

    Torben V. Borchert;Ruben Abagyan;Rainer Jaenicke;Rik K. Wierenga

  • Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power

    John C. Williams;Johan P. Zeelen;Gitte Neubauer;Gert Vriend

Frequent Co-Authors

J. Kalervo Hiltunen
J. Kalervo Hiltunen University of Oulu
Martin E.M. Noble
Martin E.M. Noble Newcastle University
Johanna Myllyharju
Johanna Myllyharju University of Oulu
Fred R. Opperdoes
Fred R. Opperdoes Université Catholique de Louvain
Paul A. M. Michels
Paul A. M. Michels University of Edinburgh
Wim G. J. Hol
Wim G. J. Hol University of Washington
Peter Neubauer
Peter Neubauer Technical University of Berlin
Toshiyuki Fukao
Toshiyuki Fukao Gifu University
Rainer Jaenicke
Rainer Jaenicke University of Regensburg
Anne-Marie Lambeir
Anne-Marie Lambeir University of Antwerp

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