Johanna Myllyharju

Overview

Best Publications

• Collagens, modifying enzymes and their mutations in humans, flies and worms

  Johanna Myllyharju;Kari I. Kivirikko

  1539
  Citations

• Collagens and collagen-related diseases

  Johanna Myllyharju;Kari I Kivirikko

  993
  Citations

• Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

  Maija Hirsilä;Peppi Koivunen;Volkmar Günzler;Kari I. Kivirikko

  972
  Citations

• Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates POSSIBLE LINKS BETWEEN CELL METABOLISM AND STABILIZATION OF HIF

  Peppi Koivunen;Maija Hirsilä;Anne M. Remes;Ilmo E. Hassinen

  624
  Citations

• Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis.

  Johanna Myllyharju

  590
  Citations

• Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

  Peppi Koivunen;Maija Hirsilä;Volkmar Günzler;Kari I. Kivirikko

  525
  Citations

• Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

  Kari I. Kivirikko;Johanna Myllyharju

  409
  Citations

• Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues.

  Joni M. Mäki;Raija Sormunen;Sari Lippo;Riitta Kaarteenaho-Wiik

  365
  Citations

• Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets

  Johanna Myllyharju

  293
  Citations

• Prolyl 4-hydroxylation regulates Argonaute 2 stability

  Hank H. Qi;Pat P. Ongusaha;Johanna Myllyharju;Dongmei Cheng

  279
  Citations

• Characterization of the iron‐ and 2‐oxoglutarate‐binding sites of human prolyl 4‐hydroxylase

  Johanna Myllyharju;Kari I. Kivirikko

  272
  Citations

• Assembly of human prolyl 4‐hydroxylase and type III collagen in the yeast Pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl 4‐hydroxylase

  Annamari Vuorela;Johanna Myllyharju;Ritva Nissi;Taina Pihlajaniemi

  265
  Citations

• Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

  Maija Hirsilä;Peppi Koivunen;Leon Xu;Todd Seeley

  263
  Citations

• Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

  Jens Köditz;Jutta Nesper;Marieke Wottawa;Daniel P. Stiehl

  252
  Citations

• Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

  Minna Heikkilä;Annika Pasanen;Kari I. Kivirikko;Johanna Myllyharju

  245
  Citations

• Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

  Huifang Xu;Nicolas Raynal;Stavros Stathopoulos;Johanna Myllyharju

  205
  Citations

• Characterization of Human Type III Collagen Expressed in a Baculovirus System PRODUCTION OF A PROTEIN WITH A STABLE TRIPLE HELIX REQUIRES COEXPRESSION WITH THE TWO TYPES OF RECOMBINANT PROLYL 4-HYDROXYLASE SUBUNIT

  Arja Lamberg;Tarja Helaakoski;Johanna Myllyharju;Sirkku Peltonen

  192
  Citations

• Cloning of the Human Prolyl 4-Hydroxylase α Subunit Isoform α(II) and Characterization of the Type II Enzyme Tetramer THE α(I) AND α(II) SUBUNITS DO NOT FORM A MIXED α(I)α(II)β2 TETRAMER

  Pia Annunen;Tarja Helaakoski;Johanna Myllyharju;Johanna Veijola

  192
  Citations

• High‐level production of human type I collagen in the yeast Pichia pastoris

  Minna Nokelainen;Hongmin Tu;Annamari Vuorela;Holger Notbohm

  182
  Citations

• Cloning and characterization of a low molecular weight prolyl 4-hydroxylase from Arabidopsis thaliana. Effective hydroxylation of proline-rich, collagen-like, and hypoxia-inducible transcription factor alpha-like peptides.

  Reija Hieta;Johanna Myllyharju

  178
  Citations