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Christopher J. Schofield

Christopher J. Schofield

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Biology and Biochemistry
UK
2026

D-Index & Metrics

Chemistry

D-Index
115
Citations
64494
World Ranking
612
National Ranking
29

Biology and Biochemistry

D-Index
119
Citations
66979
World Ranking
660
National Ranking
34

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2013 - Fellow of the Royal Society, United Kingdom

Overview

Christopher J. Schofield is a researcher affiliated with the University of Oxford in the United Kingdom. Their work spans several fields within biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular biology and cancer research.

Their research addresses topics including:

  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • Antibiotic Resistance in Bacteria
  • Computational Drug Discovery Methods
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Metal-Catalyzed Oxygenation Mechanisms
  • Cancer-related gene regulation

Christopher J. Schofield has published extensively in various scientific venues, frequently contributing to:

  • bioRxiv (Cold Spring Harbor Laboratory) - 20 publications
  • Journal of Biological Chemistry - 13 publications
  • Journal of Medicinal Chemistry - 12 publications
  • Scientific Reports - 12 publications
  • Chemical Science - 11 publications

Some recent publications include:

  • Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane, 2022, Nature
  • Allosteric Inhibition of the SARS-CoV-2 Main Protease: Insights from Mass Spectrometry Based Assays, 2020, Angewandte Chemie International Edition
  • The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes, 2021, Nature Communications
  • Discovery of SARS-CoV-2 M pro peptide inhibitors from modelling substrate and ligand binding, 2021, Chemical Science
  • Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells, 2020, Communications Biology

Frequent collaborators include:

  • Anthony Tumber (59 joint publications)
  • Lennart Brewitz (47 joint publications)
  • E. Salah (42 joint publications)
  • Patrick Rabe (26 joint publications)
  • M.A. McDonough (26 joint publications)

Their work notably intersects with areas of molecular medicine, infectious diseases, and materials chemistry, reflecting a multidisciplinary approach to scientific inquiry.

Christopher J. Schofield was recognized as a Fellow of the Royal Society, United Kingdom, in 2013.

Best Publications

  • Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

    Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson

  • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

    Andrew C.R. Epstein;Jonathan M. Gleadle;Luke A. McNeill;Kirsty S. Hewitson

  • Oxygen sensing by HIF hydroxylases

    Christopher J. Schofield;Peter J. Ratcliffe

  • The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase

    Thomas Gerken;Christophe A. Girard;Yi-Chun Loraine Tung;Celia J. Webby

  • The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

    Rasheduzzaman Chowdhury;Kar Kheng Yeoh;Ya-Min Tian;Lars Hillringhaus

  • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

    Laurens Kruidenier;Chun-wa Chung;Zhongjun Cheng;John Liddle

  • Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

    Kirsty S. Hewitson;Luke A. McNeill;Madeline V. Riordan;Ya-Min Tian

  • Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

    Wai-Ching Hon;Michael I. Wilson;Karl Harlos;Timothy D. W. Claridge

  • Expanding chemical biology of 2-oxoglutarate oxygenases

    Christoph Loenarz;Christopher J Schofield

  • Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

    Christopher J Schofield;Zhihong Zhang

  • Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

    Peter L. Roach;Ian J. Clifton;Charles M. H. Hensgens;Norio Shibata

  • Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

    Peter L. Roach;Ian J. Clifton;Vilmos Fülöp;Karl Harlos

  • Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins

    Ian J. Clifton;Michael A. McDonough;Dominic Ehrismann;Nadia J. Kershaw

  • Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.

    Jonathan M. Elkins;Kirsty S. Hewitson;Luke A. McNeill;Jürgen F. Seibel

  • Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana

    Rupert C Wilmouth;Jonathan J Turnbull;Richard W.D Welford;Ian J Clifton

  • Signalling hypoxia by HIF hydroxylases.

    Christopher J. Schofield;Peter J. Ratcliffe

  • Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

    Celia J. Webby;Alexander Wolf;Natalia Gromak;Mathias Dreger

  • Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).

    Michael A. McDonough;Vivian Li;Emily Flashman;Rasheduzzaman Chowdhury

  • Inhibition of 2-oxoglutarate dependent oxygenases

    Nathan R. Rose;Michael A. McDonough;Oliver N. F. King;Akane Kawamura

  • 2-Oxoglutarate-Dependent Oxygenases

    Md. Saiful Islam;Thomas M. Leissing;Rasheduzzaman Chowdhury;Richard J. Hopkinson;Richard J. Hopkinson

  • Structure of a cephalosporin synthase

    Karin Valegård;Anke C. Terwisscha van Scheltinga;Matthew D. Lloyd;Takane Hara

Frequent Co-Authors

Jack E. Baldwin
Jack E. Baldwin University of Oxford
Michael A. McDonough
Michael A. McDonough University of Oxford
Timothy D. W. Claridge
Timothy D. W. Claridge University of Oxford
Peter J. Ratcliffe
Peter J. Ratcliffe The Francis Crick Institute
Udo Oppermann
Udo Oppermann University of Oxford
Robert M. Adlington
Robert M. Adlington University of Oxford
Christopher W. Pugh
Christopher W. Pugh University of Oxford
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Anton Simeonov
Anton Simeonov National Institutes of Health

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