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Biology and Biochemistry

D-Index
76
Citations
23818
World Ranking
4993
National Ranking
96

Overview

Roland H. Wenger is affiliated with the University of Zurich in Switzerland. Their research focuses primarily on biochemistry, genetics, and molecular biology, with a significant contribution to medicine. They have produced a substantial body of work across related subfields including molecular biology, cancer research, hematology, genetics, and biomedical engineering.

Key topics explored in Wenger's publications encompass cancer, hypoxia, and metabolism; erythropoietin and anemia treatment; erythrocyte function and pathophysiology; advanced X-ray imaging techniques; mitochondrial function and pathology; high altitude and hypoxia; and hemoglobin structure and function.

Some notable recent papers authored or co-authored by Wenger include:

  • "Interfering with Tumor Hypoxia for Radiotherapy Optimization," 2021, Journal of Experimental & Clinical Cancer Research
  • "The transcriptional and regulatory identity of erythropoietin producing cells," 2023, Nature Medicine
  • "Intrinsic TGF-β signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease," 2023, Nature Communications
  • "Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration," 2020, Scientific Reports
  • "The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease," 2020, Antioxidants and Redox Signaling

Wenger has published multiple articles in a range of scientific journals, frequently contributing to the International Journal of Molecular Sciences, Antioxidants and Redox Signaling, Journal of the American Society of Nephrology, Pflügers Archiv - European Journal of Physiology, and Journal of Cellular Physiology.

The scientist has collaborated extensively with a number of co-authors, including Carsten C. Scholz, Andreas M. Bapst, Vartan Kurtcuoglu, Stellor Nlandu Khodo, and Thomas Knöpfel. These collaborations reflect a consistent interdisciplinary approach across their research activities.

Best Publications

  • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α

    Narayan V. Iyer;Lori E. Kotch;Faton Agani;Sandra W. Leung

  • HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia

    Deborah M. Stroka;Tobias Burkhardt;Isabelle Desbaillets;Roland H. Wenger

  • Induction of HIF-1alpha in response to hypoxia is instantaneous.

    Ursula R. Jewell;Ivica Kvietikova;Annette Scheid;Christian Bauer

  • Erythropoietin gene expression in human, monkey and murine brain.

    H H Marti;R H Wenger;L A Rivas;U Straumann

  • Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.

    K Gradin;J McGuire;R H Wenger;I Kvietikova

  • Oxygen-regulated Transferrin Expression Is Mediated by Hypoxia-inducible Factor-1

    Andreas Rolfs;Ivica Kvietikova;Max Gassmann;Roland H. Wenger

  • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

    Annika Unruh;Anke Ressel;Hamid G Mohamed;Randall S Johnson

  • Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the phosphatidylinositol 3-kinase pathway

    Daniel P Stiehl;Wolfgang Jelkmann;Roland H Wenger;Thomas Hellwig-Bürgel

  • Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

    Jesus Cosin-Roger;Simona Simmen;Hassan Melhem;Kirstin Atrott

  • Mitochondrial Reactive Oxygen Species Control the Transcription Factor CHOP-10/GADD153 and Adipocyte Differentiation A MECHANISM FOR HYPOXIA-DEPENDENT EFFECT

    Audrey Carrière;Maria-Carmen Carmona;Yvette Fernandez;Michel Rigoulet

  • Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha.

    Dmitri Chilov;Gieri Camenisch;Ivica Kvietikova;Urs Ziegler

  • The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site

    Ivica Kvietikova;Roland H. Wenger;Hugo H. Marti;Max Gassmann

  • Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor

    Jens Köditz;Jutta Nesper;Marieke Wottawa;Daniel P. Stiehl

  • Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.

    Dmitriy Lukashev;Boris Klebanov;Hidefumi Kojima;Alex Grinberg

  • Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies

    P Ebbesen;E O Pettersen;T A Gorr;G Jobst

  • Heat Induction of the Unphosphorylated Form of Hypoxia-inducible Factor-1α Is Dependent on Heat Shock Protein-90 Activity

    Dörthe M. Katschinski;Luu Le;Daniel Heinrich;Klaus F. Wagner

  • Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site

    Roland H. Wenger;Ivica Kvietikova;Andreas Rolfs;Gieri Camenisch

  • Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes

    Yang Liu;Roland H. Wenger;Roland H. Wenger;Min Zhao;Peter J. Nielsen

  • Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells

    Max Gassmann;Joachim Fandrey;Sandrine Bichet;Maria Wartenberg

  • General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia-inducible factor 1alpha.

    Gieri Camenisch;Mauro Tini;Dmitri Chilov;Ivica Kvietikova

Frequent Co-Authors

Max Gassmann
Max Gassmann University of Zurich
Peggy J. Farnham
Peggy J. Farnham University of Southern California
Kathleen J. Millen
Kathleen J. Millen Seattle Children's Hospital
Robert F. Hevner
Robert F. Hevner University of California, San Diego
Paola Bovolenta
Paola Bovolenta Spanish National Research Council
Bruce E. Torbett
Bruce E. Torbett Seattle Children's Hospital
Elizabeth M. Simpson
Elizabeth M. Simpson University of British Columbia
Wyeth W. Wasserman
Wyeth W. Wasserman University of British Columbia
Reiner A. Veitia
Reiner A. Veitia Université Paris Cité
Sylvie Mader
Sylvie Mader University of Montreal

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