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Molecular Biology

D-Index
81
Citations
23311
World Ranking
962
National Ranking
512

Overview

W. Lee Kraus is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans the fields of biochemistry, genetics, and molecular biology, with a significant focus also on medicine. Kraus's work is particularly centered on molecular biology, oncology, physiology, cancer research, and immunology.

Their main research topics include:

  • PARP inhibition in cancer therapy
  • RNA research and splicing
  • Genomics and chromatin dynamics
  • DNA repair mechanisms
  • Calcium signaling and nucleotide metabolism
  • RNA modifications and cancer
  • CRISPR and genetic engineering

Kraus has collaborated extensively with frequent coauthors such as Tulip Nandu, Cristel V. Camacho, Sridevi Challa, Jayanthi Lea, and Hyung Bum Kim.

Their scholarly contributions have appeared frequently in well-regarded publication venues, including bioRxiv (Cold Spring Harbor Laboratory), Journal of the Endocrine Society, Cancer Research, Gynecologic Oncology, and Molecular Cell.

Recent notable papers include:

  • "ADP-ribosyltransferases, an update on function and nomenclature," 2021, published in FEBS Journal
  • "The expanding universe of PARP1-mediated molecular and therapeutic mechanisms," 2022, published in Molecular Cell
  • "PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis," 2020, published in Genes & Development
  • "Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance," 2021, published in Experimental & Molecular Medicine
  • "PARPs in lipid metabolism and related diseases," 2021, published in Progress in Lipid Research

Best Publications

  • New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.

    Bryan A. Gibson;W. Lee Kraus

  • Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal

    Mi Young Kim;Tong Zhang;W. Lee Kraus

  • The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

    Raga Krishnakumar;W. Lee Kraus

  • On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

    Xin Luo;W. Lee Kraus

  • PARP Goes Transcription

    W.Lee Kraus;John T Lis

  • NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1

    Mi Young Kim;Steven Mauro;Nicolas Gévry;John T. Lis

  • PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

    Rebecca Gupte;Ziying Liu;W. Lee Kraus

  • A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells

    Nasun Hah;Charles G. Danko;Leighton Core;Joshua J. Waterfall

  • Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation.

    W Lee Kraus

  • Enhancer transcripts mark active estrogen receptor binding sites

    Nasun Hah;Shino Murakami;Anusha Nagari;Charles G. Danko

  • Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.

    Raga Krishnakumar;Matthew J. Gamble;Kristine M. Frizzell;Jhoanna G. Berrocal

  • p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation.

    William L Kraus;James T. Kadonaga

  • Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

    Bryan A. Gibson;Yajie Zhang;Hong Jiang;Kristine M. Hussey

  • Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells.

    Charles G. Danko;Nasun Hah;Xin Luo;Xin Luo;André L. Martins

  • PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway

    Raga Krishnakumar;W. Lee Kraus

  • SIRT1-dependent Regulation of Chromatin and Transcription: Linking NAD+ Metabolism and Signaling to the Control of Cellular Functions

    Tong Zhang;W. Lee Kraus

  • PARP-1 and gene regulation: Progress and puzzles

    W. Lee Kraus;Michael O. Hottiger

  • Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates.

    W. Lee Kraus;E. Tory Manning;James T. Kadonaga

  • Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes.

    Brent Brower-Toland;David A. Wacker;Robert M. Fulbright;John T. Lis

  • Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

    Young Ho Lee;Scott A. Coonrod;W. Lee Kraus;Mary Anne Jelinek

Frequent Co-Authors

John T. Lis
John T. Lis Cornell University
Adam Siepel
Adam Siepel Cold Spring Harbor Laboratory
Joaquín M. Espinosa
Joaquín M. Espinosa University of Colorado Anschutz Medical Campus
Khandan Keyomarsi
Khandan Keyomarsi The University of Texas MD Anderson Cancer Center
Benita S. Katzenellenbogen
Benita S. Katzenellenbogen University of Illinois at Urbana-Champaign
Michelle Craig Barton
Michelle Craig Barton The University of Texas MD Anderson Cancer Center
Sharon Y.R. Dent
Sharon Y.R. Dent The University of Texas MD Anderson Cancer Center
Scott A. Coonrod
Scott A. Coonrod Cornell University
Hening Lin
Hening Lin Howard Hughes Medical Institute
Vivian G. Cheung
Vivian G. Cheung University of Michigan–Ann Arbor

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