His primary scientific interests are in Cell biology, Chromatin, Biochemistry, Regulation of gene expression and Poly ADP ribose polymerase. His research in Cell biology intersects with topics in Chromatin remodeling and Transcription. The concepts of his Transcription study are interwoven with issues in Molecular biology, Estrogen receptor alpha and Estrogen receptor binding.
His research integrates issues of Enhancer, Histone and DNA methylation in his study of Chromatin. The various areas that W. Lee Kraus examines in his Regulation of gene expression study include Gene expression and Transcriptional regulation. W. Lee Kraus has researched Poly ADP ribose polymerase in several fields, including Chemical biology, Cell nucleus, Signal transduction and DNA repair.
W. Lee Kraus mainly investigates Cell biology, Chromatin, Regulation of gene expression, Transcription and Genetics. His Cell biology research integrates issues from Molecular biology, Transcription coregulator, Estrogen receptor, Estrogen receptor alpha and NAD+ kinase. While the research belongs to areas of Estrogen receptor alpha, W. Lee Kraus spends his time largely on the problem of Transcriptome, intersecting his research to questions surrounding Non-coding RNA.
His studies deal with areas such as Histone and Poly ADP ribose polymerase as well as Chromatin. His work deals with themes such as RNA, Nuclear receptor and Gene expression, which intersect with Regulation of gene expression. His Genetics study which covers Computational biology that intersects with Genomics.
W. Lee Kraus spends much of his time researching Cell biology, Enhancer, Gene expression, Transcription and Regulation of gene expression. His biological study spans a wide range of topics, including Transcriptome, Transcriptional regulation, Estrogen receptor, Estrogen receptor alpha and NAD+ kinase. He has included themes like Cancer research, Ovarian cancer and Signal transduction in his Gene expression study.
His Transcription study combines topics in areas such as PARP inhibitor and DNA repair. He combines subjects such as RNA, Nuclear receptor and Messenger RNA with his study of Regulation of gene expression. His Histone course of study focuses on Chromatin and Proteomics.
Transcription, Enhancer, Transcription factor, Cell biology and Regulation of gene expression are his primary areas of study. W. Lee Kraus interconnects Cancer cell, Cancer research and DNA repair in the investigation of issues within Transcription. His DNA repair research includes themes of Chromatin, Computational biology and DNA damage.
His Transcription factor research is classified as research in Genetics. His studies deal with areas such as Nuclear receptor coactivator 3, Estrogen receptor, Bromodomain and Nuclear receptor coactivator 2 as well as Cell biology. His Regulation of gene expression study incorporates themes from Evolutionary biology, Messenger RNA, RNA and Locus.
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New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.
Bryan A. Gibson;W. Lee Kraus.
Nature Reviews Molecular Cell Biology (2012)
Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal
Mi Young Kim;Tong Zhang;W. Lee Kraus.
Genes & Development (2005)
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
Raga Krishnakumar;W. Lee Kraus.
Molecular Cell (2010)
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
Xin Luo;W. Lee Kraus.
Genes & Development (2012)
PARP Goes Transcription
W.Lee Kraus;John T Lis.
NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1
Mi Young Kim;Steven Mauro;Nicolas Gévry;John T. Lis.
A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells
Nasun Hah;Charles G. Danko;Leighton Core;Joshua J. Waterfall.
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation.
W Lee Kraus.
Current Opinion in Cell Biology (2008)
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
Rebecca Gupte;Ziying Liu;W. Lee Kraus.
Genes & Development (2017)
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.
Raga Krishnakumar;Matthew J. Gamble;Kristine M. Frizzell;Jhoanna G. Berrocal.
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