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Molecular Biology

D-Index
53
Citations
11704
World Ranking
2381
National Ranking
1179

Overview

Joaquín M. Espinosa is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with significant work in molecular biology, public health, environmental and occupational health, immunology, genetics, and infectious diseases.

The scientist's research focuses on multiple prominent topics including Down syndrome and intellectual disability research, immunodeficiency and autoimmune disorders, epigenetics and DNA methylation, COVID-19 clinical research studies, ubiquitin and proteasome pathways, cancer-related molecular pathways, and long-term effects of COVID-19.

Frequent coauthors of Joaquín M. Espinosa include Matthew D. Galbraith, Kelly D. Sullivan, Angela L. Rachubinski, Paula Araya, and Keith P. Smith.

Joaquín M. Espinosa has contributed multiple papers to various scientific journals. Notable recent publications include:

  • Down Syndrome and COVID-19: A Perfect Storm?, 2020, Cell Reports Medicine
  • Enhanced T cell effector activity by targeting the Mediator kinase module, 2022, Science
  • Further understanding the connection between Alzheimer's disease and Down syndrome, 2020, Alzheimer's & Dementia
  • Specialized interferon action in COVID-19, 2022, Proceedings of the National Academy of Sciences
  • Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model, 2023, Nature Genetics

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, eLife, Nature Communications, and Cancer Research.

Best Publications

  • The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

    Lei Zhong;Agustina D'Urso;Debra Toiber;Carlos Sebastian

  • Transcriptional regulation by hypoxia inducible factors

    Veronica L. Dengler;Matthew D. Galbraith;Joaquín M. Espinosa

  • Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

    Joaquin M Espinosa;Beverly M Emerson

  • CDK8 is a positive regulator of transcriptional elongation within the serum response network

    Aaron J Donner;Christopher C Ebmeier;Dylan J Taatjes;Joaquín M Espinosa

  • RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

    Kira Glover-Cutter;Soojin Kim;Joaquin M Espinosa;David L Bentley

  • Mechanisms of transcriptional regulation by p53.

    Kelly D Sullivan;Matthew D Galbraith;Zdenek Andrysik;Joaquin M Espinosa;Joaquin M Espinosa

  • HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

    Matthew D. Galbraith;Mary A. Allen;Claire L. Bensard;Xiaoxing Wang;Xiaoxing Wang

  • p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage.

    Joaquı́n M Espinosa;Ramiro E Verdun;Beverly M Emerson

  • CDK8 is a stimulus-specific positive coregulator of p53 target genes.

    Aaron Joseph Donner;Stephanie Szostek;Jennifer Michelle Hoover;Joaquin Maximiliano Espinosa

  • Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

    Nathan P. Gomes;Glen Bjerke;Briardo Llorente;Stephanie A. Szostek

  • Trisomy 21 consistently activates the interferon response.

    Kelly D Sullivan;Hannah C Lewis;Amanda A Hill;Ahwan Pandey

  • The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

    Matthew T. Knuesel;Krista D. Meyer;Aaron J. Donner;Joaquin M. Espinosa

  • CDK8: a positive regulator of transcription.

    Matthew D Galbraith;Aaron J Donner;Joaquín M Espinosa

  • Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary A nn Allen;Zdenek Andrysik;Zdenek Andrysik;Veronica L. Dengler;Veronica L. Dengler;Hestia S. Mellert;Hestia S. Mellert

  • Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation.

    Kelly D. Sullivan;Donald Evans;Ahwan Pandey;Thomas H. Hraha

  • Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

    Brent E. Fitzwalter;Christina G. Towers;Kelly D. Sullivan;Zdenek Andrysik

  • Mechanisms of regulatory diversity within the p53 transcriptional network.

    J M Espinosa

  • Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

    Zdenek Andrysik;Zdenek Andrysik;Matthew D Galbraith;Matthew D Galbraith;Anna L Guarnieri;Anna L Guarnieri;Sara Zaccara

  • Down Syndrome and COVID-19: A Perfect Storm?

    Joaquin M. Espinosa

  • CDK8 is a positive regulator of transcriptional elongation within the serum response network.

    Joaquin M Espinosa;Aaron J Donner;Matthew Galbraith;Dylan Taatjes

Frequent Co-Authors

Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver
Kirk C. Hansen
Kirk C. Hansen University of Colorado Anschutz Medical Campus
Dylan J. Taatjes
Dylan J. Taatjes University of Colorado Boulder
James DeGregori
James DeGregori University of Colorado Anschutz Medical Campus
Alberto R. Kornblihtt
Alberto R. Kornblihtt University of Buenos Aires
Aik Choon Tan
Aik Choon Tan University of Utah
Alessandro Quattrone
Alessandro Quattrone University of Trento
Heide L. Ford
Heide L. Ford University of Colorado Anschutz Medical Campus
Alberto Inga
Alberto Inga University of Trento
Bing Ren
Bing Ren New York Genome Center

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