World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
30344
World Ranking
5463
National Ranking
2593

Overview

James DeGregori is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research spans multiple areas within medicine and molecular biology, focusing heavily on cancer and hematology.

DeGregori's scientific contributions cover a broad range of topics, with notable emphasis on:

  • Cancer Genomics and Diagnostics
  • Acute Myeloid Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Evolution and Genetic Dynamics
  • Epigenetics and DNA Methylation
  • Single-cell and Spatial Transcriptomics
  • Cancer Cells and Metastasis

Their work is published predominantly in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Subfields of study include Molecular Biology, Hematology, Cancer Research, Oncology, and Genetics.

DeGregori's recent publications demonstrate engagement with contemporary cancer research topics. Among the noteworthy papers are:

  • "Embracing cancer complexity: Hallmarks of systemic disease," 2024, Cell
  • "Cancer as a disease of old age: changing mutational and microenvironmental landscapes," 2020, British Journal of Cancer
  • "Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells," 2020, Cell Stem Cell
  • "Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion," 2021, Proceedings of the National Academy of Sciences
  • "Clonal hematopoiesis: Mutation-specific adaptation to environmental change," 2022, Cell Stem Cell

The number of citations for these papers indicates their relevance in the field, with counts ranging from over 100 to more than 300 citations.

Frequent co-authors with whom DeGregori has collaborated include:

  • Eric M. Pietras (14 co-authored works)
  • Marco De Dominici (10 co-authored works)
  • Andrew Goodspeed (10 co-authored works)
  • Edward J. Evans (9 co-authored works)
  • Frédéric Thomas (8 co-authored works)

Leading journals and venues featuring DeGregori's research include:

  • Cancer Research (21 publications)
  • Blood (9 publications)
  • Aging and Cancer (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 preprints)
  • Evolutionary Applications (4 publications)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.

    James DeGregori;Timothy Kowalik;Joseph R. Nevins

  • Distinct roles for E2F proteins in cell growth control and apoptosis

    James DeGregori;Gustavo Leone;Alexander Miron;Laszlo Jakoi

  • Regulation of the cyclin E gene by transcription factor E2F1.

    K Ohtani;J DeGregori;J R Nevins

  • Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

    James DeGregori;David G. Johnson

  • Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

    Gustavo Leone;James DeGregori;Rosalie Sears;Laszlo Jakoi

  • Ras Enhances Myc Protein Stability

    Rosalie Sears;Gustavo Leone;James DeGregori;Joseph R Nevins

  • E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

    Timothy F. Kowalik;James DeGregori;James K. Schwarz;Joseph R. Nevins

  • Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.

    Samir N. Khleif;James Degregori;Carole L. Yee;Gregory A. Otterson

  • Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.

    Courtney L. Jones;Brett M. Stevens;Angelo D'Alessandro;Julie A. Reisz

  • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

    Gustavo Leone;James DeGregori;Zhen Yan;Laszlo Jakoi

  • The genetics of the E2F family of transcription factors: shared functions and unique roles.

    James DeGregori

  • The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

    E J Smith;G Leone;J DeGregori;L Jakoi

  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

    Zhen Yan;James DeGregori;Ralph Shohet;Gustavo Leone

  • The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

    Günter U. Höglinger;Joshua J. Breunig;Candan Depboylu;Caroline Rouaux

  • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

    James DeGregori;Gustavo Leone;Kiyoshi Ohtani;Alexander Miron

  • Trisomy 21 consistently activates the interferon response.

    Kelly D Sullivan;Hannah C Lewis;Amanda A Hill;Ahwan Pandey

  • Role of the Rb/E2F pathway in cell growth control.

    Joseph R. Nevins;Gustavo Leone;James DeGregori;Laszlo Jakoi

  • E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2

    TF Kowalik;J DeGregori;G Leone;L Jakoi

  • TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

    Pavel Davizon-Castillo;Brandon McMahon;Sonia Aguila;David Bark

Frequent Co-Authors

Joseph R. Nevins
Joseph R. Nevins Duke University
Aik Choon Tan
Aik Choon Tan University of Utah
Gustavo Leone
Gustavo Leone Medical University of South Carolina
Angelo D'Alessandro
Angelo D'Alessandro University of Colorado Denver
Craig T. Jordan
Craig T. Jordan University of Colorado Anschutz Medical Campus
Travis Nemkov
Travis Nemkov University of Colorado Denver
Kirk C. Hansen
Kirk C. Hansen University of Colorado Anschutz Medical Campus
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
Timm Schroeder
Timm Schroeder ETH Zurich
Lynn E. Heasley
Lynn E. Heasley University of Colorado Anschutz Medical Campus

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