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D-Index & Metrics

Molecular Biology

D-Index
68
Citations
16987
World Ranking
1513
National Ranking
768

Overview

Aik Choon Tan is affiliated with the University of Utah in the United States. Their research primarily centers on medicine, with specific contributions to biochemistry, genetics, and molecular biology. Within these broad fields, their work extensively covers oncology, molecular biology, cancer research, pulmonary and respiratory medicine, and immunology.

The scientist's research topics include:

  • Cancer Immunotherapy and Biomarkers
  • Cancer Genomics and Diagnostics
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Ferroptosis and cancer prognosis
  • Melanoma and MAPK Pathways
  • Protein Degradation and Inhibitors

They have published frequently in the following venues:

  • Cancer Research
  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Regular and Young Investigator Award Abstracts
  • Molecular Carcinogenesis

Some of their recent papers include:

  • Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion (2021, Proceedings of the National Academy of Sciences)
  • Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures (2020, Nature Communications)
  • Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations (2021, Nature Ecology & Evolution)
  • Pre-Treatment Mutational and Transcriptomic Landscape of Responding Metastatic Melanoma Patients to Anti-PD1 Immunotherapy (2020, Cancers)
  • MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells (2020, Cell Death and Disease)

Frequently collaborating with other researchers, their regular coauthors include:

  • Ahmad A. Tarhini
  • Michelle L. Churchman
  • Martin D. McCarter
  • Sheetal Hardikar
  • José R. Conejo-García

Best Publications

  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

    Qian Huang;Fang-Fang Li;Xinjian Liu;Wenrong Li

  • DSigDB: drug signatures database for gene set analysis

    Minjae Yoo;Jimin Shin;Jihye Kim;Karen A. Ryall

  • Ensemble machine learning on gene expression data for cancer classification

    Aik Choon Tan;David Gilbert

  • A DNA methylation fingerprint of 1628 human samples

    Augustin F. Fernandez;Yassen Assenov;Jose Ignacio Martin-Subero;Balazs Balint

  • The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

    Anna L Smith;Ritsuko Iwanaga;David J Drasin;Douglas S Micalizzi

  • Tumor Engraftment in Nude Mice and Enrichment in Stroma- Related Gene Pathways Predict Poor Survival and Resistance to Gemcitabine in Patients with Pancreatic Cancer

    Ignacio Garrido-Laguna;Ignacio Garrido-Laguna;Maria Uson;N. V. Rajeshkumar;Aik Choon Tan;Aik Choon Tan

  • AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

    Shanshan Pei;Mohammad Minhajuddin;Biniam Adane;Nabilah Khan

  • Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.

    Xinjian Liu;Xinjian Liu;Fang Li;Elizabeth A. Stubblefield;Barbara Blanchard

  • GSEA-InContext: identifying novel and common patterns in expression experiments.

    Unknown

  • Characterizing DNA methylation patterns in pancreatic cancer genome.

    Aik Choon Tan;Antonio Jimeno;Steven Hsesheng Lin;Jenna Wheelhouse

  • Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data

    Lei Xu;Aik Choon Tan;Daniel Q. Naiman;Donald Geman

  • Multi-class protein fold classification using a new ensemble machine learning approach.

    Aik Choon Tan;David Gilbert;Yves Deville

  • Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition

    Matias Casas-Selves;Jihye Kim;Zhiyong Zhang;Barbara A Helfrich

  • Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer

    Kurtis D. Davies;Sakshi Mahale;David P. Astling;Dara L. Aisner

  • Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

    Curtis J. Henry;Curtis J. Henry;Matias Casás-Selves;Jihye Kim;Vadym Zaberezhnyy

  • A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells

    Oliver A. Kent;Michael Mullendore;Eric A. Wentzel;Pedro López-Romero

  • Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies.

    Iñigo Landa;Nikita Pozdeyev;Christopher Korch;Laura A. Marlow

  • Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

    James M. Haughian;Mauricio P. Pinto;J. Chuck Harrell;Brian S. Bliesner

  • Collagen architecture in pregnancy-induced protection from breast cancer

    Ori Maller;Kirk C. Hansen;Traci R. Lyons;Irene Acerbi;Irene Acerbi

  • XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer.

    J. Jason Morton;Gregory Bird;Stephen B. Keysar;David P. Astling

Frequent Co-Authors

Wells A. Messersmith
Wells A. Messersmith University of Colorado Boulder
Antonio Jimeno
Antonio Jimeno University of Colorado Boulder
Lynn E. Heasley
Lynn E. Heasley University of Colorado Anschutz Medical Campus
Jaewoo Kang
Jaewoo Kang Korea University
James DeGregori
James DeGregori University of Colorado Anschutz Medical Campus
Manuel Hidalgo
Manuel Hidalgo Cornell University
David Gilbert
David Gilbert Brunel University London
Xiao-Jing Wang
Xiao-Jing Wang University of California, Davis
Fred R. Hirsch
Fred R. Hirsch Mount Sinai Hospital
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus

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