2026 Mario F. Fraga: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Genetics	104	642	608	8	8	307	48847
Molecular Biology	104	459	417	6	6	307	48847

Research.com Recognitions

2026 - Research.com Genetics in Spain Leader Award
2026 - Research.com Molecular Biology in Spain Leader Award
2025 - Research.com Genetics in Spain Leader Award
2024 - Research.com Genetics in Spain Leader Award
2023 - Research.com Genetics in Spain Leader Award

Overview

Mario F. Fraga is affiliated with the University of Oviedo in Spain. Their research spans various areas within biochemistry, genetics, and molecular biology, with a significant focus on medicine. Their body of work includes a notable presence in molecular biology, cancer research, oncology, genetics, and physiology.

The scientist's publications cover several key topics, including:

Epigenetics and DNA Methylation
RNA modifications and cancer
Cancer Genomics and Diagnostics
Pluripotent Stem Cells Research
CRISPR and Genetic Engineering
Genomics and Chromatin Dynamics
Genetics, Aging, and Longevity in Model Organisms

Among their recent papers are the following:

"Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation," 2021, Molecular Metabolism
"Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming," 2022, Aging Cell
"Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases," 2020, Nature Cell Biology
"Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome," 2020, Blood
"Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies," 2021, JNCI Journal of the National Cancer Institute

Their research has appeared in a variety of publication venues, including:

Zenodo (CERN European Organization for Nuclear Research)
bioRxiv (Cold Spring Harbor Laboratory)
Blood
Clinical Epigenetics
International Journal of Molecular Sciences

Frequent collaborators in their research include Agustín F. Fernández, Juan Ramón Tejedor, Raúl F. Pérez, Pablo Santamarina-Ojeda, and Rocío G. Urdinguio. These co-authors have contributed substantially to various projects and publications alongside Mario F. Fraga.

Best Publications

Epigenetic differences arise during the lifetime of monozygotic twins

Mario F. Fraga;Esteban Ballestar;Maria F. Paz;Santiago Ropero

4288
Citations
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo;Linda B. Luecke;Christoph Kahlert;Agustin F. Fernandez

2750
Citations
The Polycomb group protein EZH2 directly controls DNA methylation

Emmanuelle Viré;Carmen Brenner;Rachel Deplus;Loïc Blanchon

2552
Citations
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F Fraga;Esteban Ballestar;Ana Villar-Garea;Manuel Boix-Chornet

2313
Citations
Epigenetics and the environment: emerging patterns and implications.

Robert Feil;Mario F. Fraga;Mario F. Fraga

1967
Citations
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.

Victoria Bolós;Hector Peinado;Mirna A Pérez-Moreno;Mirna A Pérez-Moreno;Mario F Fraga

1409
Citations
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells

Amaia Lujambio;Santiago Ropero;Esteban Ballestar;Mario F. Fraga

1147
Citations
Epigenetics and aging: the targets and the marks

Mario F. Fraga;Manel Esteller

877
Citations
Distinct DNA methylomes of newborns and centenarians

Holger Heyn;Ning Li;Humberto J. Ferreira;Sebastian Moran

865
Citations
Child health, developmental plasticity, and epigenetic programming.

Z. Hochberg;Robert Feil;M. Constancia;M. Fraga

762
Citations
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

Biola M. Javierre;Agustin F. Fernandez;Julia Richter;Fatima Al-Shahrour

723
Citations
DNA methyltransferases control telomere length and telomere recombination in mammalian cells.

Susana Gonzalo;Isabel Jaco;Mario F. Fraga;Taiping Chen

718
Citations
DNA methylation: a profile of methods and applications.

Mario F. Fraga;Manel Esteller

690
Citations
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

Manel Esteller;Mario F. Fraga;Mingzhou Guo;Jesus Garcia-Foncillas

580
Citations
A Systematic Profile of DNA Methylation in Human Cancer Cell Lines

Maria F. Paz;Mario F. Fraga;Sonia Avila;Mingzhou Guo

507
Citations
A DNA methylation fingerprint of 1628 human samples

Augustin F. Fernandez;Yassen Assenov;Jose Ignacio Martin-Subero;Balazs Balint

446
Citations
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.

Ana Villar-Garea;Mario F Fraga;Jesus Espada;Manel Esteller

437
Citations
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

O Aguilera;M F Fraga;E Ballestar;M F Paz

436
Citations
Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer

Esteban Ballestar;Maria F. Paz;Laura Valle;Susan Wei

425
Citations
Erratum: The Polycomb group protein EZH2 directly controls DNA methylation

Emmanuelle Viré;Carmen Brenner;Rachel Deplus;Loïc Blanchon

3
Citations

Frequent Co-Authors

Agustín F. Fernández University of Oviedo

Manel Esteller Josep Carreras Leukaemia Research Institute

Esteban Ballestar University of Valencia

Pablo Menendez University of Barcelona

José M. Mato CIC bioGUNE

Manuel Serrano Institució Catalana de Recerca i Estudis Avançats

Allan Vaag Steno Diabetes Center

Shelly C. Lu Cedars-Sinai Medical Center

Ioana Berindan-Neagoe Iuliu Hațieganu University of Medicine and Pharmacy

Roland Rad Technical University of Munich

External Links

Personal website of Mario F. Fraga

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