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Biology and Biochemistry

D-Index
52
Citations
8985
World Ranking
16749
National Ranking
1321

Overview

Paul Eggleton is a researcher affiliated with the University of Exeter in the United Kingdom. Their work spans multiple domains within medicine, biochemistry, genetics, molecular biology, and immunology. They have contributed significantly to understanding the molecular and cellular mechanisms underlying inflammatory and immune-related diseases.

Their research has been published in a variety of scientific journals, with frequent contributions to:

  • Journal of Allergy and Clinical Immunology
  • International Journal of Molecular Sciences
  • Biomedicines
  • Cancer Immunology Immunotherapy
  • Journal of Cellular and Molecular Medicine

Key subjects of Paul Eggleton's research include immunology, cell biology, neurology, molecular biology, and rheumatology. Among these, immunology and related immune cell functions have been a strong focus, alongside investigations into neuroinflammation mechanisms and endoplasmic reticulum stress in disease contexts.

The main research topics addressed in their work are:

  • Endoplasmic Reticulum Stress and Disease
  • Immune Cell Function and Interaction
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Food Allergy and Anaphylaxis Research
  • Antimicrobial Peptides and Activities
  • Interferon and Immune Responses
  • Inflammasome and Immune Disorders

Paul Eggleton has collaborated repeatedly with several coauthors, demonstrating ongoing research partnerships. Frequent collaborators include Miranda J. Smallwood, Jia Newcombe, Janet E. Holley, Jorge De Alba, and Roly Foulkes.

Among their recent publications are:

  • "STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases," 2023, published in Biomedicines
  • "Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells," 2021, published in Cancer Immunology Immunotherapy
  • "The therapeutic mavericks: Potent immunomodulating chaperones capable of treating human diseases," 2023, published in Journal of Cellular and Molecular Medicine
  • "The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis," 2020, published in The FASEB Journal
  • "Engagement of people with multiple sclerosis to enhance research into the physiological effect of hyperbaric oxygen therapy," 2020, published in Multiple Sclerosis and Related Disorders

Best Publications

  • A second serine protease associated with mannan-binding lectin that activates complement

    Steffen Thiel;Thomas Vorup-Jensen;Cordula M. Stover;Wilhelm Schwaeble

  • Calreticulin: non-endoplasmic reticulum functions in physiology and disease

    Leslie I. Gold;Paul Eggleton;Mariya T. Sweetwyne;Lauren B. Van Duyn

  • The ins and outs of calreticulin: from the ER lumen to the extracellular space.

    Steven Johnson;Marek Michalak;Michal Opas;Paul Eggleton

  • Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.

    K L Hartshorn;E C Crouch;M R White;P Eggleton

  • Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages.

    T Madan;P Eggleton;U Kishore;P Strong

  • Lung surfactant proteins A and D can inhibit specific IgE binding to the allergens of Aspergillus fumigatus and block allergen‐induced histamine release from human basophils

    T. Madan;U. Kishore;A. Shah;P. Eggleton

  • Thrombospondin Mediates Focal Adhesion Disassembly through Interactions with Cell Surface Calreticulin

    Silvia Goicoechea;Anthony Wayne Orr;Manuel Antonio Pallero;Paul Eggleton

  • Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils.

    U. Wirthmueller;B. Dewald;M. Thelen;M. K.-H. Schafer

  • Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus.

    Suzanne Donnelly;Wendy Roake;Simon Brown;Philip Young

  • The Conformation of Calreticulin Is Influenced by the Endoplasmic Reticulum Luminal Environment

    Elaine F.Corbett;Karolina M. Michalak;Kim Oikawa;Steven Johnson

  • The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells.

    Christian Honoré;Tina Hummelshoj;Bjarke E. Hansen;Hans O. Madsen

  • Rapid method for the isolation of neutrophils in high yield without the use of dextran or density gradient polymers.

    Paul Eggleton;Robert Gargan;Derek Fisher

  • Mechanisms of Translocation of ER Chaperones to the Cell Surface and Immunomodulatory Roles in Cancer and Autoimmunity.

    Valerie R. Wiersma;Marek Michalak;Trefa M. Abdullah;Edwin Bremer

  • The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin.

    Silvia Goicoechea;Manuel Antonio Pallero;Paul Eggleton;Marek Michalak

  • A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins

    Grit Kasper;Alan Brown;Matthias Eberl;Laurent Vallar

  • Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease

    Paul G. Winyard;Brent Ryan;Paul Eggleton;Ahuva Nissim

  • A mechanism of release of calreticulin from cells during apoptosis.

    Joanna M. Tarr;Philip J. Young;Robert Morse;Debra J. Shaw

  • The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury?

    Elizabeth Perry;Clive Kelly;Paul Eggleton;Anthony De Soyza

  • Calreticulin Is Released from Activated Neutrophils and Binds to C1q and Mannan-Binding Protein

    P. Eggleton;T.S. Lieu;E.G. Zappi;K. Sastry

  • Consequence of neo-antigenicity of the ‘altered self’

    P. Eggleton;R. Haigh;P. G. Winyard

Frequent Co-Authors

Paul G. Winyard
Paul G. Winyard University of Exeter
Kenneth B. M. Reid
Kenneth B. M. Reid University of Oxford
Marek Michalak
Marek Michalak University of Alberta
Wijnand Helfrich
Wijnand Helfrich University Medical Center Groningen
Uday Kishore
Uday Kishore Brunel University London
Matthew Whiteman
Matthew Whiteman University of Exeter
Berhane Ghebrehiwet
Berhane Ghebrehiwet Stony Brook University
David A. Isenberg
David A. Isenberg University College London
Lorna W. Harries
Lorna W. Harries University of Exeter
Alfred I. Tauber
Alfred I. Tauber Boston University

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