Nicole M. Thielens mainly investigates Biochemistry, Complement system, Proteases, Serine and Lectin. As part of her studies on Biochemistry, Nicole M. Thielens often connects relevant subjects like Molecular biology. Her study looks at the relationship between Complement system and fields such as Cell biology, as well as how they intersect with chemical problems.
Her Proteases research integrates issues from Complement C1q and Mannan-binding lectin. While the research belongs to areas of Classical complement pathway, Nicole M. Thielens spends her time largely on the problem of Protein structure, intersecting her research to questions surrounding Structural biology. Nicole M. Thielens interconnects Protein superfamily and Protein subunit in the investigation of issues within Innate immune system.
Her primary areas of investigation include Biochemistry, Complement system, Classical complement pathway, Cell biology and Proteases. Her Binding site, Mannan-binding lectin, Serine protease, Lectin and Ficolin study are her primary interests in Biochemistry. Her Complement system research incorporates themes from Innate immune system, Sialic acid and Recombinant DNA.
The Classical complement pathway study combines topics in areas such as Biophysics, Complement C1q and C3-convertase. Her research integrates issues of Protein structure, Receptor, PTX3 and Complement in her study of Cell biology. Her biological study spans a wide range of topics, including Tetramer, Computational biology and Serine.
Nicole M. Thielens mostly deals with Complement system, Classical complement pathway, Cell biology, Immunology and Innate immune system. She is interested in Lectin pathway, which is a branch of Complement system. Nicole M. Thielens has researched Classical complement pathway in several fields, including Serine protease, Alternative complement pathway, Recombinant DNA, Proteases and Biochemistry.
Her biological study focuses on Multiprotein complex. The various areas that Nicole M. Thielens examines in her Cell biology study include Receptor and Complement C1q. Her Innate immune system study incorporates themes from Virus and Glycoprotein.
Her primary areas of study are Complement system, Classical complement pathway, Virus, Innate immune system and Cell biology. Her research on Complement system focuses in particular on Pentraxins. Her Pentraxins study integrates concerns from other disciplines, such as Mutation, Complement C1q, Pattern recognition receptor and Proteases.
Her Classical complement pathway research is multidisciplinary, relying on both T cell, Cytotoxic T cell, CD8 and Immunopathology. Her Innate immune system research includes elements of Lectin pathway, Alternative complement pathway and Biophysics. The Cell biology study which covers Receptor that intersects with Mannan-binding lectin, Complement control protein, Complement Receptor Type 1 and Protein engineering.
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Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41.
C F Ebenbichler;N M Thielens;R Vornhagen;P Marschang.
Journal of Experimental Medicine (1991)
Structure and activation of the C1 complex of complement: unraveling the puzzle
Christine Gaboriaud;Nicole M Thielens;Lynn A Gregory;Véronique Rossi.
Trends in Immunology (2004)
Substrate Specificities of Recombinant Mannan-binding Lectin-associated Serine Proteases-1 and -2
Véronique Rossi;Sandor Cseh;Isabelle Bally;Nicole M. Thielens.
Journal of Biological Chemistry (2001)
Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition
Ying Jie Ma;Andrea Doni;Tina Hummelshøj;Christian Honoré.
Journal of Biological Chemistry (2009)
Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals
Mette Møller-Kristensen;Jens Chr. Jensenius;Lisbeth Jensen;Nicole Thielens.
Journal of Immunological Methods (2003)
Structural insights into the Slit-Robo complex
Cecile Morlot;Nicole M. Thielens;Raimond B. G. Ravelli;Wieger Hemrika.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins.
Virginie Garlatti;Nicolas Belloy;Lydie Martin;Monique Lacroix.
The EMBO Journal (2007)
C1q: A fresh look upon an old molecule.
Nicole M. Thielens;Francesco Tedesco;Suzanne S. Bohlson;Christine Gaboriaud.
Molecular Immunology (2017)
Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions
Alexis Broisat;Sophie Hernot;Jakub Toczek;Jens De Vos.
Circulation Research (2012)
The Two Major Oligomeric Forms of Human Mannan-Binding Lectin: Chemical Characterization, Carbohydrate-Binding Properties, and Interaction with MBL-Associated Serine Proteases
Florence Teillet;Bernard Dublet;Jean-Pierre Andrieu;Christine Gaboriaud.
Journal of Immunology (2005)
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