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Nicole M. Thielens

Nicole M. Thielens

D-Index & Metrics

Biology and Biochemistry

D-Index
62
Citations
10234
World Ranking
11053
National Ranking
402

Overview

Nicole M. Thielens is affiliated with Grenoble Alpes University in France. Their research spans multiple areas within medicine and immunology, with a particular focus on the complement system and infectious diseases.

The scientist's recent papers include the following:

  • DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist, 2021, PLoS Pathogens
  • Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts, 2020, The Lancet Rheumatology
  • DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality, 2021, Frontiers in Immunology
  • Molecular and Cellular Interactions of Scavenger Receptor SR-F1 With Complement C1q Provide Insights Into Its Role in the Clearance of Apoptotic Cells, 2020, Frontiers in Immunology

Nicole M. Thielens frequently collaborates with several researchers, including:

  • Isabelle Bally
  • Christine Gaboriaud
  • Chantal Dumestre-Pérard
  • Véronique Rossi
  • Jean-Baptiste Reiser

Their work is regularly published in venues such as:

  • Frontiers in Immunology (9 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Immunobiology (5 publications)
  • FEBS Journal (2 publications)
  • Methods in Molecular Biology (2 publications)

Main fields of study include Medicine with 54 publications and Immunology and Microbiology with 43 publications. Subfields of study focus on Immunology (43 publications), Infectious Diseases (12 publications), Radiology, Nuclear Medicine and Imaging (11 publications), Hematology (11 publications), and Molecular Biology (8 publications).

The main research topics covered by Nicole M. Thielens are:

  • Complement system in diseases
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses
  • Systemic Lupus Erythematosus Research
  • Advanced Glycation End Products research
  • Blood Coagulation and Thrombosis Mechanisms

Best Publications

  • Structure and activation of the C1 complex of complement: unraveling the puzzle

    Christine Gaboriaud;Nicole M Thielens;Lynn A Gregory;Véronique Rossi

  • Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41.

    C F Ebenbichler;N M Thielens;R Vornhagen;P Marschang

  • Substrate Specificities of Recombinant Mannan-binding Lectin-associated Serine Proteases-1 and -2

    Véronique Rossi;Sandor Cseh;Isabelle Bally;Nicole M. Thielens

  • C1q: A fresh look upon an old molecule.

    Nicole M. Thielens;Francesco Tedesco;Suzanne S. Bohlson;Christine Gaboriaud

  • Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition

    Ying Jie Ma;Andrea Doni;Tina Hummelshøj;Christian Honoré

  • Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals

    Mette Møller-Kristensen;Jens Chr. Jensenius;Lisbeth Jensen;Nicole Thielens

  • Structural insights into the Slit-Robo complex

    Cecile Morlot;Nicole M. Thielens;Raimond B. G. Ravelli;Wieger Hemrika

  • Nanobodies targeting mouse/human VCAM1 for the nuclear imaging of atherosclerotic lesions

    Alexis Broisat;Sophie Hernot;Jakub Toczek;Jens De Vos

  • Structural Insights Into the Innate Immune Recognition Specificities of L- and H-Ficolins.

    Virginie Garlatti;Nicolas Belloy;Lydie Martin;Monique Lacroix

  • DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist.

    Michel Thépaut;Joanna Luczkowiak;Corinne Vivès;Nuria Labiod

  • The Two Major Oligomeric Forms of Human Mannan-Binding Lectin: Chemical Characterization, Carbohydrate-Binding Properties, and Interaction with MBL-Associated Serine Proteases

    Florence Teillet;Bernard Dublet;Jean-Pierre Andrieu;Christine Gaboriaud

  • Interaction Properties of Human Mannan-Binding Lectin (MBL)-Associated Serine Proteases-1 and -2, MBL-Associated Protein 19, and MBL

    Nicole M. Thielens;Sándor Cseh;Steffen Thiel;Thomas Vorup-Jensen

  • Studies on the interactions between C‐reactive protein and complement proteins

    Adrienn Bíró;Zita Rovó;Diana Papp;László Cervenak

  • C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism

    Guang Sheng Ling;Greg Crawford;Norzawani Buang;Istvan Bartok

  • The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.

    Monika Budayova‐Spano;Monique Lacroix;Nicole M. Thielens;Gérard J. Arlaud

  • Interaction of C1q and mannan-binding lectin with viruses.

    Nicole M. Thielens;Pascale Tacnet-Delorme;Gérard J. Arlaud

  • Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s. Evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate.

    Véronique Rossi;Isabelle Bally;Nicole M. Thielens;Alfred F. Esser

  • Identification of the C1q-binding Sites of Human C1r and C1s A REFINED THREE-DIMENSIONAL MODEL OF THE C1 COMPLEX OF COMPLEMENT

    Isabelle Bally;Véronique Rossi;Thomas Lunardi;Nicole M. Thielens

  • Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate the Complement System

    Maiken Lumby Henriksen;Jette Brandt;Jean-Piere Andrieu;Jean-Piere Andrieu;Jean-Piere Andrieu;Christian Nielsen

  • New Methods in Cardiovascular Biology Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions

    Alexis Broisat;Sophie Hernot;Jakub Toczek;Jens De Vos

Frequent Co-Authors

Gérard J. Arlaud
Gérard J. Arlaud Centre national de la recherche scientifique, CNRS
Steffen Thiel
Steffen Thiel Aarhus University
Guy Schoehn
Guy Schoehn Grenoble Alpes University
Jean Gagnon
Jean Gagnon University of Montreal
Juan C. Fontecilla-Camps
Juan C. Fontecilla-Camps Centre national de la recherche scientifique, CNRS
Zoltán Prohászka
Zoltán Prohászka Semmelweis University
Teizo Fujita
Teizo Fujita Fukushima Prefectural General Hygiene Institute
Thierry Vernet
Thierry Vernet French Alternative Energies and Atomic Energy Commission (CEA)
Misao Matsushita
Misao Matsushita Tokai University
George Füst
George Füst Semmelweis University

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