What is she best known for?
The fields of study she is best known for:
Nicole M. Thielens mainly investigates Biochemistry, Complement system, Proteases, Serine and Lectin.
As part of her studies on Biochemistry, Nicole M. Thielens often connects relevant subjects like Molecular biology.
Her study looks at the relationship between Complement system and fields such as Cell biology, as well as how they intersect with chemical problems.
Her Proteases research integrates issues from Complement C1q and Mannan-binding lectin.
While the research belongs to areas of Classical complement pathway, Nicole M. Thielens spends her time largely on the problem of Protein structure, intersecting her research to questions surrounding Structural biology.
Nicole M. Thielens interconnects Protein superfamily and Protein subunit in the investigation of issues within Innate immune system.
Her most cited work include:
- Structure and activation of the C1 complex of complement: unraveling the puzzle (188 citations)
- Human immunodeficiency virus type 1 activates the classical pathway of complement by direct C1 binding through specific sites in the transmembrane glycoprotein gp41. (179 citations)
- Substrate Specificities of Recombinant Mannan-binding Lectin-associated Serine Proteases-1 and -2 (165 citations)
What are the main themes of her work throughout her whole career to date?
Her primary areas of investigation include Biochemistry, Complement system, Classical complement pathway, Cell biology and Proteases.
Her Binding site, Mannan-binding lectin, Serine protease, Lectin and Ficolin study are her primary interests in Biochemistry.
Her Complement system research incorporates themes from Innate immune system, Sialic acid and Recombinant DNA.
The Classical complement pathway study combines topics in areas such as Biophysics, Complement C1q and C3-convertase.
Her research integrates issues of Protein structure, Receptor, PTX3 and Complement in her study of Cell biology.
Her biological study spans a wide range of topics, including Tetramer, Computational biology and Serine.
She most often published in these fields:
- Biochemistry (61.67%)
- Complement system (43.75%)
- Classical complement pathway (32.08%)
What were the highlights of her more recent work (between 2017-2021)?
- Complement system (43.75%)
- Classical complement pathway (32.08%)
- Cell biology (22.50%)
In recent papers she was focusing on the following fields of study:
Nicole M. Thielens mostly deals with Complement system, Classical complement pathway, Cell biology, Immunology and Innate immune system.
She is interested in Lectin pathway, which is a branch of Complement system.
Nicole M. Thielens has researched Classical complement pathway in several fields, including Serine protease, Alternative complement pathway, Recombinant DNA, Proteases and Biochemistry.
Her biological study focuses on Multiprotein complex.
The various areas that Nicole M. Thielens examines in her Cell biology study include Receptor and Complement C1q.
Her Innate immune system study incorporates themes from Virus and Glycoprotein.
Between 2017 and 2021, her most popular works were:
- C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism (63 citations)
- Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex. (18 citations)
- Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers. (13 citations)
In her most recent research, the most cited papers focused on:
Her primary areas of study are Complement system, Classical complement pathway, Virus, Innate immune system and Cell biology.
Her research on Complement system focuses in particular on Pentraxins.
Her Pentraxins study integrates concerns from other disciplines, such as Mutation, Complement C1q, Pattern recognition receptor and Proteases.
Her Classical complement pathway research is multidisciplinary, relying on both T cell, Cytotoxic T cell, CD8 and Immunopathology.
Her Innate immune system research includes elements of Lectin pathway, Alternative complement pathway and Biophysics.
The Cell biology study which covers Receptor that intersects with Mannan-binding lectin, Complement control protein, Complement Receptor Type 1 and Protein engineering.
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