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Immunology

D-Index
68
Citations
13746
World Ranking
2625
National Ranking
1250

Overview

Berhane Ghebrehiwet is affiliated with Stony Brook University in the United States. Their research primarily focuses on fields related to Medicine and Immunology and Microbiology, with a substantial number of publications in these areas. Subfields of notable contribution include Immunology, Genetics, Molecular Biology, Infectious Diseases, and Hematology.

The scientist's research encompasses a range of topics with a particular concentration on the complement system in diseases, coagulation pathways including bradykinin and polyphosphates, and clinical studies of COVID-19. Key areas of work include monoclonal and polyclonal antibodies research, mast cells and histamine, blood groups and transfusion science, as well as investigations related to SARS-CoV-2 and COVID-19.

Frequent publication venues for Ghebrehiwet's work include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Frontiers in Immunology
  • Frontiers in Oncology
  • The FASEB Journal
  • Frontiers in Allergy

Among recent significant papers are:

  • "SARS-CoV-2 Exacerbates COVID-19 Pathology Through Activation of the Complement and Kinin Systems" (2021), published in Frontiers in Immunology
  • "Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis" (2021), published in Cellular and Molecular Gastroenterology and Hepatology
  • "Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology" (2020), published in Journal of Clinical Investigation
  • "gC1qR/HABP1/p32 Is a Potential New Therapeutic Target Against Mesothelioma" (2020), published in Frontiers in Oncology
  • "GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells" (2020), published in Frontiers in Oncology

Their frequent co-authors include Anne G. Savitt, Ellinor I.B. Peerschke, David A. Rubenstein, Wei Yin, and Allen P. Kaplan, reflecting collaborative work across multiple studies.

Best Publications

  • C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

    Carol Anne Ogden;Aimee deCathelineau;Peter R. Hoffmann;Donna Bratton

  • Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.

    B Ghebrehiwet;B L Lim;E I Peerschke;A C Willis

  • gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes.

    Laurence Braun;Berhane Ghebrehiwet;Pascale Cossart

  • C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

    Helena Païdassi;Pascale Tacnet-Delorme;Virginie Garlatti;Claudine Darnault

  • Activation of the classical pathway of complement by Hageman factor fragment.

    B Ghebrehiwet;M Silverberg;A P Kaplan

  • Complement activation on platelets: implications for vascular inflammation and thrombosis.

    Ellinor I. Peerschke;Wei Yin;Berhane Ghebrehiwet

  • Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R).

    Kusumam Joseph;Berhane Ghebrehiwet;Ellinor I. B. Peerschke;Kenneth B. M. Reid

  • Staphylococcus aureus Protein A Recognizes Platelet gC1qR/p33: a Novel Mechanism for Staphylococcal Interactions with Platelets

    Truc Nguyen;Berhane Ghebrehiwet;Ellinor I. B. Peerschke

  • Mechanisms of activation of the classical pathway of complement by Hageman factor fragment.

    Berhane Ghebrehiwet;Bruce P. Randazzo;Joseph T. Dunn;Michael Silverberg

  • Kinin formation in hereditary angioedema plasma: evidence against kinin derivation from C2 and in support of "spontaneous" formation of bradykinin.

    Theodore Fields;Berhane Ghebrehiwet;Allen P. Kaplan

  • The plasma bradykinin-forming pathways and its interrelationships with complement

    Allen P. Kaplan;Berhane Ghebrehiwet

  • Effect of Pseudomonas aeruginosa elastase and alkaline protease on serum complement and isolated components C1q and C3.

    Yuqun Hong;Berhane Ghebrehiwet

  • gC1q-R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection.

    Berhane Ghebrehiwet;Boon-Leong Lim;Rajeev Kumar;Xiaodong Feng

  • cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection

    Berhane Ghebrehiwet;Ellinor I.B Peerschke

  • Blood platelets activate the classical pathway of human complement

    E. I. B. Peerschke;W. Yin;S. E. Grigg;B. Ghebrehiwet

  • Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity.

    Ellinor I. B. Peerschke;Kenneth B. M. Reid;Berhane Ghebrehiwet

  • C1q as a unique player in angiogenesis with therapeutic implication in wound healing

    Fleur Bossi;Claudio Tripodo;Lucia Rizzi;Roberta Bulla

  • An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

    Chiara Agostinis;Roberta Bulla;Claudio Tripodo;Angela Gismondi

  • Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations.

    Sarah Hom;Li Chen;Tony Wang;Berhane Ghebrehiwet

  • Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation.

    A. Chen;S. Gaddipati;Yuqun Hong;D. J. Volkman

  • The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor.

    Boon-Leong Lim;Kenneth B.M. Reid;Berhane Ghebrehiwet;Ellinor I.B. Peerschke

Frequent Co-Authors

Ellinor I.B. Peerschke
Ellinor I.B. Peerschke Memorial Sloan Kettering Cancer Center
Allen P. Kaplan
Allen P. Kaplan Medical University of South Carolina
Uday Kishore
Uday Kishore Brunel University London
Kenneth B. M. Reid
Kenneth B. M. Reid University of Oxford
Francesco Tedesco
Francesco Tedesco University of Trieste
Babette B. Weksler
Babette B. Weksler Cornell University
Paul Eggleton
Paul Eggleton University of Exeter
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital
Robert W. Colman
Robert W. Colman Temple University
Boon Leong Lim
Boon Leong Lim University of Hong Kong

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