2026 John D. Lambris: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	145	141	131	93	85	787	75692

Research.com Recognitions

2026 - Research.com Immunology in United States Leader Award
2025 - Research.com Immunology in United States Leader Award

Overview

John D. Lambris is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on immunology, with significant contributions to understanding the complement system and its role in various diseases. Lambris's work spans multiple intersecting fields including medicine, immunology and microbiology, and molecular biology.

The scientist's main fields of study include:

Medicine
Immunology and Microbiology

Within these areas, subfields of research comprise:

Immunology
Infectious Diseases
Hematology
Molecular Biology
Public Health, Environmental and Occupational Health

Lambris's research covers several key topics, such as:

Complement system in diseases
COVID-19 Clinical Research Studies
SARS-CoV-2 and COVID-19 Research
Inflammasome and immune disorders
Blood Coagulation and Thrombosis Mechanisms
Platelet Disorders and Treatments
Immunotherapy and Immune Responses

Frequent coauthors in their collaborations include Dimitrios C. Mastellos, Despina Yancopoulou, Markus Huber-Lang, Cecília Garlanda, and Antonio M. Risitano.

Lambris has contributed to a variety of publications with repeated appearances in notable scientific journals. The most common publication venues are:

Seminars in Immunology
Frontiers in Immunology
Nature reviews. Immunology
Clinical Immunology
The Journal of Immunology

Recent selected papers reflecting their research include:

"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis" (2020, Journal of Clinical Investigation)
"Complement as a target in COVID-19?" (2020, Nature reviews. Immunology)
"Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy" (2020, Periodontology 2000)
"The first case of COVID-19 treated with the complement C3 inhibitor AMY-101" (2020, Clinical Immunology)
"Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy" (2020, Clinical Immunology)

This body of work illustrates a focus on immune mechanisms involved in infectious disease, particularly COVID-19, as well as on the complement system's influence on inflammatory and coagulation pathways.

Best Publications

Complement: a key system for immune surveillance and homeostasis

Daniel Ricklin;George Hajishengallis;Kun Yang;John D Lambris

4137
Citations
The classical complement cascade mediates CNS synapse elimination.

Beth Stevens;Nicola J. Allen;Luis E. Vazquez;Gareth R. Howell

3578
Citations
Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

George Hajishengallis;Shuang Liang;Mark A. Payne;Ahmed Hashim

1281
Citations
Generation of C5a in the absence of C3: a new complement activation pathway.

Markus Huber-Lang;J Vidya Sarma;Firas S Zetoune;Daniel Rittirsch

1197
Citations
Modulation of the antitumor immune response by complement

Maciej M Markiewski;Robert A DeAngelis;Fabian Benencia;Fabian Benencia;Salome K Ricklin-Lichtsteiner

907
Citations
Complement evasion by human pathogens

John D. Lambris;Daniel Ricklin;Brian V. Geisbrecht

900
Citations
The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight

Maciej M. Markiewski;John D. Lambris

859
Citations
Drusen complement components C3a and C5a promote choroidal neovascularization

Miho Nozaki;Brian J. Raisler;Eiji Sakurai;J. Vidya Sarma

821
Citations
Molecular Intercommunication between the Complement and Coagulation Systems

Umme Amara;Michael A. Flierl;Daniel Rittirsch;Andreas Klos

815
Citations
Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.

Panagiotis Skendros;Alexandros Mitsios;Akrivi Chrysanthopoulou;Dimitrios C. Mastellos

785
Citations
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

Guillermina Girardi;Jessica Berman;Patricia Redecha;Lynn Spruce

782
Citations
The complement system in teleosts.

M.Claire H. Holland;John D. Lambris

739
Citations
Complement and coagulation: strangers or partners in crime?

Maciej M. Markiewski;Bo Nilsson;Kristina Nilsson Ekdahl;Tom Eirik Mollnes;Tom Eirik Mollnes

722
Citations
Structure and biology of complement protein C3, a connecting link between innate and acquired immunity

Arvind Sahu;John D. Lambris

667
Citations
Complement in disease: a defence system turning offensive

Daniel Ricklin;Edimara S. Reis;John D. Lambris

647
Citations
Complement-targeted therapeutics.

Daniel Ricklin;John D Lambris

623
Citations
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

Daniel Ricklin;John D. Lambris

622
Citations
Innate immune responses to trauma

Markus Huber-Lang;John D. Lambris;Peter A. Ward

604
Citations
Interaction between the coagulation and complement system.

Umme Amara;Daniel Rittirsch;Michael Flierl;Uwe Bruckner

594
Citations
Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense

Daniel Ricklin;Edimara S. Reis;Dimitrios C. Mastellos;Piet Gros

583
Citations
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

Tony Wyss-Coray;Fengrong Yan;Amy Hsiu-Ti Lin;John D. Lambris

568
Citations
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation

Tom Eirik Mollnes;Ole-Lars Brekke;Michael Fung;Hilde Fure

551
Citations

Frequent Co-Authors

Daniel Ricklin University of Basel

Tom Eirik Mollnes Oslo University Hospital

Bo Nilsson Uppsala University

George Hajishengallis University of Pennsylvania

Kristina Nilsson Ekdahl Uppsala University

Markus Huber-Lang University of Ulm

Piet Gros Utrecht University

Florea Lupu Oklahoma Medical Research Foundation

Terje Espevik Norwegian University of Science and Technology

Rick A. Wetsel The University of Texas Health Science Center at Houston

External Links

Wikipedia of John D. Lambris Personal website of John D. Lambris

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