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Microbiology

D-Index
74
Citations
16415
World Ranking
1599
National Ranking
50

Overview

Trent M. Woodruff is affiliated with the University of Queensland in Australia. Their research contributions span multiple fields, primarily focusing on medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. The subfields of study in which they are actively engaged include immunology, neurology, molecular biology, physiology, and cellular and molecular neuroscience.

Woodruff's work covers several main topics, highlighting areas such as the complement system in diseases, neuroinflammation and neurodegeneration mechanisms, amyotrophic lateral sclerosis research, adenosine and purinergic signaling, immune cell function and interaction, receptor mechanisms and signaling, and monoclonal and polyclonal antibodies research.

Their recent scholarly publications include:

  • SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein (2022, Molecular Psychiatry)
  • COVID-19: Complement, Coagulation, and Collateral Damage (2020, The Journal of Immunology)
  • Processed foods drive intestinal barrier permeability and microvascular diseases (2021, Science Advances)
  • Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation (2021, Science Immunology)
  • Complement in human disease: approved and up-and-coming therapeutics (2023, The Lancet)

Among frequent coauthors collaborating with Woodruff are:

  • John D. Lee
  • Xaria X. Li
  • Richard J. Clark
  • Vinod Kumar
  • Jenny N. Fung

Woodruff's publications appear regularly in a variety of scientific venues. The most frequent include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunobiology
  • The Journal of Immunology
  • Frontiers in Immunology
  • The FASEB Journal

Best Publications

  • Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

    Richard Gordon;Eduardo A. Albornoz;Daniel C. Christie;Monica R. Langley

  • Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

    Trent M. Woodruff;John Thundyil;Sung Chun Tang;Christopher G. Sobey

  • Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment

    Kevin D. Beck;Hal X. Nguyen;Manuel D. Galvan;Desirée L. Salazar

  • T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

    Giuseppina Arbore;Erin E. West;Rosanne Spolski;Avril A. B. Robertson

  • The role of the complement system in ischemia-reperfusion injury.

    Thiruma Arumugam;Ian Shiels;Trent Woodruff;D Granger

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors

    Stephen P.H. Alexander;Arthur Christopoulos;Anthony P. Davenport;Eamonn Kelly

  • Toll-like receptors in ischemia-reperfusion injury.

    Thiruma V. Arumugam;Eitan Okun;Sung-Chun Tang;John Thundyil

  • Inhibiting the C5–C5a receptor axis

    Trent M. Woodruff;Kutty S. Nandakumar;Francesco Tedesco

  • Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease.

    Maria I. Fonseca;Rahasson R. Ager;Shu Hui Chu;Ozkan Yazan

  • Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

    Liam G. Coulthard;Trent M. Woodruff

  • Neutrophils--a key component of ischemia-reperfusion injury.

    Zoe Victoria Schofield;Trent Martin Woodruff;Reena Halai;Mike Chia-Lun Wu

  • Eph/Ephrin signaling in injury and inflammation.

    Mark G. Coulthard;Michael Morgan;Trent M. Woodruff;Thiruma V. Arumugam

  • C5L2: a controversial receptor of complement anaphylatoxin, C5a

    Rui Li;Liam G. Coulthard;M. C. L. Wu;Stephen M. Taylor

  • Complement component 5a (C5a).

    Helga D. Manthey;Trent M. Woodruff;Stephen M. Taylor;Peter N. Monk

  • SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

    Unknown

  • The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.

    Vandana Deora;John D. Lee;Eduardo A. Albornoz;Luke McAlary

  • Neuroprotection in stroke by complement inhibition and immunoglobulin therapy.

    Thiruma V. Arumugam;Trent M. Woodruff;Justin D. Lathia;Pradeep K. Selvaraj

  • The Role of the Complement System and the Activation Fragment C5a in the Central Nervous System

    Trent M. Woodruff;Rahasson R. Ager;Andrea J. Tenner;Peter G. Noakes

  • The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis

    Trent M. Woodruff;Kerina J. Costantini;James W. Crane;Julie D. Atkin

  • Complement mediators in ischemia-reperfusion injury

    Thiruma V. Arumugam;Tim Magnus;Trent M. Woodruff;Lavinia M. Proctor

  • A Potent Human C5a Receptor Antagonist Protects against Disease Pathology in a Rat Model of Inflammatory Bowel Disease

    Trent M. Woodruff;Thiruma V. Arumugam;Ian A. Shiels;Robert C. Reid

  • Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration

    Trent M. Woodruff;James W. Crane;Lavinia. M. Proctor;Kathryn M. Buller

  • The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

    Mike C. L. Wu;Faith H. Brennan;Jason P. L. Lynch;Susanna Mantovani

  • A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats.

    Anna J. Strachan;Trent M. Woodruff;Gerald Haaima;David P. Fairlie

Frequent Co-Authors

Peter N. Monk
Peter N. Monk University of Sheffield
Peter G. Noakes
Peter G. Noakes University of Queensland
David P. Fairlie
David P. Fairlie University of Queensland
Claudia Kemper
Claudia Kemper National Institutes of Health
Thiruma V. Arumugam
Thiruma V. Arumugam La Trobe University
Mark E. Cooper
Mark E. Cooper Monash University
Marc J. Ruitenberg
Marc J. Ruitenberg University of Queensland
Tom Eirik Mollnes
Tom Eirik Mollnes Oslo University Hospital
Terje Espevik
Terje Espevik Norwegian University of Science and Technology
Rick A. Wetsel
Rick A. Wetsel The University of Texas Health Science Center at Houston

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