Werner J.H. Koopman

Overview

Best Publications

• Redox Homeostasis and Mitochondrial Dynamics.

  Peter H.G.M. Willems;Rodrigue Rossignol;Cindy E.J. Dieteren;Michael P. Murphy

  780
  Citations

• Monogenic Mitochondrial Disorders

  Werner J H Koopman;Peter H G M Willems;Jan A M Smeitink

  568
  Citations

• Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells.

  Farhan Basit;Lisanne Mpe van Oppen;Laura Schöckel;Hasse M Bossenbroek

  495
  Citations

• Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

  Werner J.H. Koopman;Leo G.J. Nijtmans;Cindy E.J. Dieteren;Peggy Roestenberg

  470
  Citations

• Mitochondrial function and morphology are impaired in parkin mutant fibroblasts

  Heather Mortiboys;Kelly Jean Thomas;Werner J. H. Koopman;Stefanie Klaffke

  425
  Citations

• Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

  Dania C. Liemburg-Apers;Peter H. G. M. Willems;Werner J. H. Koopman;Sander Grefte;Sander Grefte

  391
  Citations

• Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

  Felix Distelmaier;Felix Distelmaier;Werner J.H. Koopman;Lambertus P. van den Heuvel;Richard J. Rodenburg

  367
  Citations

• Inhibition of complex I of the electron transport chain causes O2−·-mediated mitochondrial outgrowth

  Werner J. H. Koopman;Sjoerd Verkaart;Henk-Jan Visch;Francois H. van der Westhuizen

  332
  Citations

• OXPHOS mutations and neurodegeneration

  Werner J H Koopman;Felix Distelmaier;Jan A M Smeitink;Peter H G M Willems

  311
  Citations

• An anaerobic mitochondrion that produces hydrogen

  Brigitte Boxma;Rob M. de Graaf;Georg W.M. van der Staay;Theo A. van Alen

  301
  Citations

• A guide to diagnosis and treatment of Leigh syndrome

  Fabian Baertling;Richard J. T. Rodenburg;Jörg Schaper;Jan A. M. Smeitink

  270
  Citations

• Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.

  Rutger O. Vogel;Rolf J.R.J. Janssen;Mariël A.M. van den Brand;Cindy E.J. Dieteren

  257
  Citations

• Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency

  Werner J. H. Koopman;Henk-Jan Visch;Sjoerd Verkaart;Lambertus W. P. J. van den Heuvel

  253
  Citations

• Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

  Martina Bajzikova;Martina Bajzikova;Jaromira Kovarova;Ana R. Coelho;Ana R. Coelho;Stepana Boukalova

  235
  Citations

• Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

  Tom J.J. Schirris;G. Herma Renkema;Tina Ritschel;Nicol C. Voermans

  231
  Citations

• Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

  Bavo Heeman;Chris Van den Haute;Sarah-Ann Aelvoet;Federica Valsecchi

  217
  Citations

• Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.

  Rutger O. Vogel;Cindy E.J. Dieteren;Lambert P. W.J. van den Heuvel;Peter H. G.M. Willems

  203
  Citations

• Simultaneous quantitative measurement and automated analysis of mitochondrial morphology, mass, potential, and motility in living human skin fibroblasts.

  Werner J H Koopman;Henk-Jan Visch;Jan A M Smeitink;Peter H G M Willems

  200
  Citations

• Quantifying ROS levels using CM-H2DCFDA and HyPer

  Monika Oparka;Jarosław Walczak;Dominika Malinska;Lisanne M.P.E. van Oppen

  188
  Citations

• Superoxide production is inversely related to complex I activity in inherited complex I deficiency

  Sjoerd Verkaart;Werner J.H. Koopman;Sjenet E. van Emst-de Vries;Leo G.J. Nijtmans

  187
  Citations