His scientific interests lie mostly in Mitochondrion, Oxidative phosphorylation, Cell biology, Biochemistry and Biogenesis. His work deals with themes such as Mutation, Molecular biology and Protein subunit, which intersect with Mitochondrion. His biological study spans a wide range of topics, including Complementation, Internal medicine, Endoplasmic reticulum and Intracellular.
The concepts of his Oxidative phosphorylation study are interwoven with issues in Oxidoreductase, Respiratory chain, Function and Mitochondrial DNA. He has included themes like RNA interference and Neurospora crassa in his Cell biology study. He has researched Biogenesis in several fields, including Oxoglutarate dehydrogenase complex and Beta oxidation.
His primary areas of study are Mitochondrion, Genetics, Oxidative phosphorylation, Molecular biology and Mutation. His Mitochondrion study combines topics in areas such as NDUFS4, Biogenesis and Mitochondrial DNA. His Oxidative phosphorylation research entails a greater understanding of Biochemistry.
His Molecular biology study also includes fields such as
Leo G.J. Nijtmans spends much of his time researching Oxidative phosphorylation, Cell biology, Genetics, Protein subunit and Inner mitochondrial membrane. His study in Oxidative phosphorylation is interdisciplinary in nature, drawing from both Gene and Mitochondrial DNA. His work on Golgi apparatus as part of his general Cell biology study is frequently connected to Extracellular matrix assembly, thereby bridging the divide between different branches of science.
His study focuses on the intersection of Protein subunit and fields such as Molecular biology with connections in the field of Mutation and Complementation. His work in Mutation covers topics such as Biogenesis which are related to areas like Mitochondrion. His Inner mitochondrial membrane research integrates issues from Protein complex assembly and Protein family.
The scientist’s investigation covers issues in Protein subunit, Oxidative phosphorylation, Mitochondrial respiratory chain complex I, Cell biology and Molecular biology. His Protein subunit research includes themes of Multiprotein complex, Biosynthesis, Nuclear gene, Respiratory chain and Computational biology. His Oxidative phosphorylation study integrates concerns from other disciplines, such as Mitochondrial matrix, Ribosomal protein, Gene mutation, Gene and Mitochondrial translation.
As part of his inquiry into Mitochondrion and Genetics, Leo G.J. Nijtmans is doing Mitochondrial respiratory chain complex I research. His research integrates issues of Ribosome, Cutis laxa and Mitochondrial disease in his study of Cell biology. In Molecular biology, Leo G.J. Nijtmans works on issues like Exome sequencing, which are connected to Complementation.
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Blue Native electrophoresis to study mitochondrial and other protein complexes.
Leo G J Nijtmans;Nadine S Henderson;Ian J Holt.
Methods (2002)
Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Werner J.H. Koopman;Leo G.J. Nijtmans;Cindy E.J. Dieteren;Peggy Roestenberg.
Antioxidants & Redox Signaling (2010)
Mitochondrial complex I: structure, function and pathology.
Rolf J. R. J. Janssen;Leo G. Nijtmans;Lambert P. van den Heuvel;Jan A. M. Smeitink.
Journal of Inherited Metabolic Disease (2006)
The Mitochondrial Prohibitin Complex Is Essential for Embryonic Viability and Germline Function in Caenorhabditis elegans
Marta Artal Sanz;William Y. Tsang;Esther M. Willems;Les A. Grivell.
Journal of Biological Chemistry (2003)
Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency
Cristina Ugalde;Rolf J.R.J. Janssen;Lambert P. van den Heuvel;Jan A.M. Smeitink.
Human Molecular Genetics (2004)
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.
Sergio Guerrero-Castillo;Sergio Guerrero-Castillo;Fabian Baertling;Fabian Baertling;Daniel Kownatzki;Hans J. Wessels.
Cell Metabolism (2017)
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
R.O. Vogel;R.J.R.J. Janssen;M.A.M. van den Brand;C.E.J. Dieteren.
Genes & Development (2007)
Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies
Cristina Ugalde;Rutger Vogel;Richard Huijbens;Bert van den Heuvel.
Human Molecular Genetics (2004)
Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.
Rutger O. Vogel;Cindy E.J. Dieteren;Lambert P. W.J. van den Heuvel;Peter H. G.M. Willems.
Journal of Biological Chemistry (2007)
Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.
Ann Saada;Rutger O. Vogel;Saskia J. Hoefs;Mariël A. van den Brand.
American Journal of Human Genetics (2009)
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