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Immunology

D-Index
66
Citations
13138
World Ranking
2790
National Ranking
247

Overview

Steven H. Sacks is affiliated with King's College London in the United Kingdom. Their research spans multiple fields within medicine, with a focus on immunology, microbiology, and transplantation.

The scientist's work is concentrated in the following main fields of study:

  • Medicine
  • Immunology and Microbiology

The subfields of study include:

  • Immunology
  • Surgery
  • Transplantation
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health

Key topics covered by their research are:

  • Complement system in diseases
  • Renal Transplantation Outcomes and Treatments
  • SARS-CoV-2 and COVID-19 Research
  • Organ Transplantation Techniques and Outcomes
  • Muscle and Compartmental Disorders
  • Organ Donation and Transplantation
  • Erythropoietin and Anemia Treatment

Recent published papers include:

  • "Rationale for targeting complement in COVID-19" (2020), published in EMBO Molecular Medicine
  • "Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis" (2020), published in Kidney International
  • "PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype" (2021), published in PLoS Biology
  • "Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney" (2020), published in American Journal of Transplantation
  • "Complement in ischaemia-reperfusion injury and transplantation" (2021), published in Seminars in Immunopathology

Frequent co-authors working with Steven H. Sacks are:

  • Conrad A. Farrar
  • Roseanna Greenlaw
  • Anastasia Polycarpou
  • Mark Howard
  • Christopher L. Nauser

The scientist regularly publishes in these venues:

  • Kidney International
  • American Journal of Transplantation
  • Seminars in Immunopathology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The biomedical & life sciences collection

Best Publications

  • Local synthesis of complement component C3 regulates acute renal transplant rejection.

    Julian R. Pratt;Shamim A. Basheer;Steven H. Sacks

  • Predominant role for C5b-9 in renal ischemia/reperfusion injury

    Wuding Zhou;Conrad A. Farrar;Katsushige Abe;Julian R. Pratt

  • Urinary tract infections: new insights into a common problem

    R Kucheria;P Dasgupta;S H Sacks;M S Khan

  • The role of complement in the early immune response to transplantation

    Steven H. Sacks;Wuding Zhou

  • Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

    Wilhelm J. Schwaeble;Nicholas J. Lynch;James E. Clark;Michael Marber

  • C3a and C5a Promote Renal Ischemia-Reperfusion Injury

    Qi Peng;Ke Li;Ke Li;Lesley A. Smyth;Guolan Xing

  • Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.

    Qi Peng;Ke Li;Katie Anderson;Conrad A. Farrar

  • Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade

    Nicola J Monk;Roseanna E G Hargreaves;James E Marsh;Conrad A Farrar

  • Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype.

    Qi Peng;Ke Li;Hetal Patel;Steven H. Sacks

  • Influence of donor C3 allotype on late renal transplantation outcome

    Katherine M. Brown;Elli Kondeatis;Robert W. Vaughan;Sui P. Kon

  • The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.

    Qi Peng;Ke Li;Steven H. Sacks;Wuding Zhou

  • Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction

    Thomas T. Tapmeier;Amy Fearn;Kathryn Brown;Paramit Chowdhury

  • Mechanical stretch induces vascular permeability factor in human mesangial cells: Mechanisms of signal transduction

    Gabriella Gruden;Stephen Thomas;Davina Burt;Stephen Lane

  • Apical Proteins Stimulate Complement Synthesis by Cultured Human Proximal Tubular Epithelial Cells

    Sydney Tang;Neil S. Sheerin;Wuding Zhou;Zarin Brown

  • Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

    Conrad A. Farrar;David Tran;Ke Li;Weiju Wu

  • Intrarenal synthesis of complement.

    Wuding Zhou;James E. Marsh;Steven H. Sacks

  • Cyclic AMP plays a critical role in C3a-receptor–mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

    Ke Li;Katie J. Anderson;Qi Peng;Alistair Noble

  • Dendritic cell function in allostimulation is modulated by C5aR signaling.

    Qi Peng;Ke Li;Naiyin Wang;Qijun Li

  • Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice

    N. S. Sheerin;T. Springall;M. C. Carroll;B. Hartley

  • Contribution of renal secreted complement C3 to the circulating pool in humans.

    Sydney Tang;Wuding Zhou;Neil S. Sheerin;Robert W. Vaughan

  • Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat.

    J. R. Pratt;M. J. Hibbs;A. J. Laver;R. A. G. Smith

Frequent Co-Authors

Graham M. Lord
Graham M. Lord University of Manchester
Robert Vaughan
Robert Vaughan Guy's Hospital
Wilhelm J. Schwaeble
Wilhelm J. Schwaeble University of Leicester
Michael C. Carroll
Michael C. Carroll Boston Children's Hospital
Terry B. Strom
Terry B. Strom Beth Israel Deaconess Medical Center
Christopher A. O’Callaghan
Christopher A. O’Callaghan University of Oxford
Myfanwy Morgan
Myfanwy Morgan King's College London
Marina Botto
Marina Botto Imperial College London
Russell Wallis
Russell Wallis University of Leicester
Michael E. Weale
Michael E. Weale King's College London

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