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Immunology

D-Index
89
Citations
27663
World Ranking
1118
National Ranking
98

Medicine

D-Index
89
Citations
27663
World Ranking
12739
National Ranking
1197

Overview

Marina Botto is affiliated with Imperial College London in the United Kingdom. Their research primarily focuses on medicine, with significant contributions to immunology and microbiology.

The scientist's work spans several subfields of study including immunology, infectious diseases, rheumatology, hematology, and neurology. Central topics in their research are:

  • Systemic Lupus Erythematosus Research
  • COVID-19 Clinical Research Studies
  • Blood Coagulation and Thrombosis Mechanisms
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Complement system in diseases

Marina Botto has published extensively in various scientific journals. Frequent publication venues include:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife
  • Frontiers in Immunology

Notable recent papers by Marina Botto include:

  • Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus, 2021, Nature Communications
  • Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response, 2022, Nature Communications
  • Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline, 2022, Science
  • PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury, 2020, Journal of Clinical Investigation
  • Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death, 2021, eLife

The scientist has collaborated frequently with several researchers, including:

  • Matthew C. Pickering
  • Candice Clarke
  • Nicholas Medjeral-Thomas
  • Michelle Willicombe
  • David Thomas

Best Publications

  • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

    M Botto;C Dell'Agnola;A E Bygrave;E M Thompson

  • Dectin-1 is required for beta-glucan recognition and control of fungal infection.

    Philip Russel Taylor;S. Vicky Tsoni;Janet A. Willment;Kevin M. Dennehy

  • A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.

    Philip R. Taylor;Anna Carugati;Valerie A. Fadok;H. Terence Cook

  • Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

    Cecilia Garlanda;Emilio Hirsch;Silvia Bozza;Antonietta Salustri

  • The Role of Complement in the Development of Systemic Lupus Erythematosus

    Anthony P Manderson;Marina Botto;Mark J Walport

  • Complement Activation Determines the Therapeutic Activity of Rituximab In Vivo

    Nicola Di Gaetano;Elena Cittera;Rachele Nota;Annunciata Vecchi

  • Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity.

    M.C.M. Bickerstaff;M. Botto;W.L. Hutchinson;J. Herbert

  • Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex

    R. William Vandivier;Carol Anne Ogden;Valerie A. Fadok;Peter R. Hoffmann

  • Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H

    Matthew C. Pickering;H. Terence Cook;Joanna Warren;Anne E. Bygrave

  • Systemic lupus erythematosus, complement deficiency, and apoptosis.

    M C Pickering;M Botto;P R Taylor;P J Lachmann

  • C1q and systemic lupus erythematosus.

    Mark J. Walport;Kevin A. Davies;Marina Botto

  • The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Jeremy S. Brown;Tracy Hussell;Sarah M. Gilliland;David W. Holden

  • Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

    Maria Isabel Fonseca;Jun Zhou;Marina Botto;Andrea J. Tenner

  • C1q, autoimmunity and apoptosis.

    Marina Botto;Mark J Walport

  • Complement facilitates early prion pathogenesis.

    M A Klein;P S Kaeser;P Schwarz;H Weyd

  • Antibodies to human serum amyloid P component eliminate visceral amyloid deposits

    Karl Bodin;Stephan Ellmerich;Melvyn C. Kahan;Glenys A. Tennent

  • Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene.

    M. Botto;P. N. Hawkins;M. C. M. Bickerstaff;J. Herbert

  • Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains

    Matthew C. Pickering;Elena Goicoechea de Jorge;Rubén Martinez-Barricarte;Sergio Recalde

  • Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

    Atsuhiko T. Naito;Tomokazu Sumida;Seitaro Nomura;Mei-Lan Liu

  • Complement in human diseases: Lessons from complement deficiencies.

    Marina Botto;Michael Kirschfink;Paolo Macor;Matthew C. Pickering

Frequent Co-Authors

Mark Walport
Mark Walport Imperial College London
H. Terence Cook
H. Terence Cook Imperial College London
Matthew C. Pickering
Matthew C. Pickering Imperial College London
Philip R. Taylor
Philip R. Taylor Cardiff University
Dorian O. Haskard
Dorian O. Haskard Imperial College London
Joseph J. Boyle
Joseph J. Boyle Imperial College London
Francesco Tedesco
Francesco Tedesco University of Trieste
Timothy J. Vyse
Timothy J. Vyse King's College London
B. Paul Morgan
B. Paul Morgan Cardiff University
Claudio Tripodo
Claudio Tripodo FIRC Institute of Molecular Oncology

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