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Molecular Biology

D-Index
67
Citations
16428
World Ranking
1570
National Ranking
27

Overview

Lukas Sommer is affiliated with the University of Zurich in Switzerland, with a research focus spanning Medicine and Biochemistry, Genetics and Molecular Biology. Their work includes significant contributions in the fields of Molecular Biology, Immunology, Oncology, Cellular and Molecular Neuroscience, and Neurology.

The main research topics explored by Lukas Sommer include:

  • Immunotherapy and Immune Responses
  • Melanoma and MAPK Pathways
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • Neurogenesis and neuroplasticity mechanisms
  • Protein Degradation and Inhibitors
  • Cancer Cells and Metastasis

Their notable recent papers cover various aspects of cancer biology and immune system interactions, including:

  • Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatment (2020) published in Stem Cells Translational Medicine
  • NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence (2021) published in Nature Communications
  • Vaccination-based immunotherapy to target profibrotic cells in liver and lung (2022) published in Cell stem cell
  • Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4 (2021) published in Nature Communications
  • Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma (2023) published in Science Advances

Frequent collaborators in their work include:

  • Salome Stierli
  • Adrián Salas-Bastos
  • Ewelina Krzywińska
  • Christian Stockmann
  • Julia Lehmann

Common venues where Lukas Sommer publishes research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • FASEB BioAdvances
  • Nature Communications
  • Cell stem cell
  • Zenodo (CERN European Organization for Nuclear Research)

Best Publications

  • Notch signalling controls pancreatic cell differentiation

    Åsa Apelqvist;Hao Li;Lukas Sommer;Paul Beatus

  • Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.

    Véronique Brault;Robert Moore;Stefanie Kutsch;Makoto Ishibashi

  • neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS

    Lukas Sommer;Qiufu Ma;David J. Anderson

  • Instructive Role of Wnt/β-Catenin in Sensory Fate Specification in Neural Crest Stem Cells

    Hye Youn Lee;Maurice Kléber;Lisette Hari;Véronique Brault

  • Lineage-specific requirements of β-catenin in neural crest development

    Lisette Hari;Véronique Brault;Maurice Kléber;Hye-Youn Lee

  • Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

    Gianluca Civenni;Anne Walter;Nikita Kobert;Daniela Mihic-Probst

  • Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling.

    Christian Paratore;Derk E. Goerich;Ueli Suter;Michael Wegner

  • Neural crest–derived cells with stem cell features can be traced back to multiple lineages in the adult skin

    Christine E. Wong;Christian Paratore;María T. Dours-Zimmermann;Ariane Rochat

  • The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

    Daniel Zingg;Julien Debbache;Simon M. Schaefer;Eylul Tuncer

  • The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy

    Daniel Zingg;Natalia Arenas-Ramirez;Dilara Sahin;Rodney A. Rosalia

  • Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.

    Dilek Colak;Tetsuji Mori;Monika S. Brill;Alexander Pfeifer

  • The cellular function of MASH1 in autonomic neurogenesis

    Lukas Sommer;Nirao Shah;Mahendra Rao;David J. Anderson

  • Development of the Schwann cell lineage: from the neural crest to the myelinated nerve.

    Ashwin Woodhoo;Lukas Sommer

  • Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

    Olga Shakhova;Daniel Zingg;Simon M. Schaefer;Lisette Hari

  • Neural crest progenitors and stem cells: From early development to adulthood

    Elisabeth Dupin;Lukas Sommer

  • Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence.

    E. Blaugrund;T.D. Pham;V.M. Tennyson;L. Lo

  • Mash1 and neurogenin1 Expression Patterns Define Complementary Domains of Neuroepithelium in the Developing CNS and Are Correlated with Regions Expressing Notch Ligands

    Qiufu Ma;Lukas Sommer;Peter Cserjesi;David J. Anderson

  • Wnt signaling and the regulation of stem cell function.

    Maurice Kléber;Lukas Sommer

  • P0 and PMP22 mark a multipotent neural crest-derived cell type that displays community effects in response to TGF-beta family factors.

    L. Hagedorn;U. Suter;L. Sommer

  • Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling.

    Maurice Kléber;Hye-Youn Lee;Heiko Wurdak;Johanna Buchstaller

Frequent Co-Authors

Ueli Suter
Ueli Suter École Polytechnique Fédérale de Lausanne
Reinhard Dummer
Reinhard Dummer University of Zurich
Mitchell P. Levesque
Mitchell P. Levesque University of Zurich
Konrad Basler
Konrad Basler University of Zurich
David J. Anderson
David J. Anderson California Institute of Technology
Michael Wegner
Michael Wegner University of Erlangen-Nuremberg
Lars M. Ittner
Lars M. Ittner Macquarie University
Makoto Mark Taketo
Makoto Mark Taketo Kyoto University
Holger Moch
Holger Moch University of Zurich
Magdalena Götz
Magdalena Götz Ludwig-Maximilians-Universität München

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