D-Index & Metrics Best Publications
Molecular Biology
USA
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Molecular Biology D-index 130 Citations 88,178 283 World Ranking 105 National Ranking 71

Research.com Recognitions

Awards & Achievements

2023 - Research.com Molecular Biology in United States Leader Award

1995 - Fellow of the American Academy of Arts and Sciences

1995 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cellular differentiation

His scientific interests lie mostly in Cell biology, Cellular differentiation, Stem cell, Internal medicine and Endocrinology. His studies deal with areas such as Embryonic stem cell, Endoderm, Cell culture, Pancreas and Cell type as well as Cell biology. His Cellular differentiation research is multidisciplinary, relying on both SOX2, Molecular biology, Homeobox protein NANOG and Directed differentiation.

His SOX2 research focuses on subjects like Cell potency, which are linked to Nanog Homeobox Protein and Rex1. Douglas A. Melton interconnects Adult stem cell, Induced pluripotent stem cell and Embryoid body in the investigation of issues within Stem cell. His Internal medicine study integrates concerns from other disciplines, such as Sonic hedgehog, Hedgehog, Notochord and Mesoderm.

His most cited work include:

  • Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter (4757 citations)
  • Core transcriptional regulatory circuitry in human embryonic stem cells. (3708 citations)
  • Core transcriptional regulatory circuitry in human embryonic stem cells. (3708 citations)

What are the main themes of his work throughout his whole career to date?

Douglas A. Melton mainly investigates Cell biology, Stem cell, Xenopus, Embryonic stem cell and Cellular differentiation. His Cell biology research incorporates themes from Cell, Endocrinology, Internal medicine, Pancreas and Endoderm. Douglas A. Melton has researched Stem cell in several fields, including In vitro, Immunology, Transplantation and Adult stem cell.

His research integrates issues of Molecular biology, Messenger RNA, Embryo and Mesoderm in his study of Xenopus. The Embryonic stem cell study combines topics in areas such as Cell culture and Regenerative medicine. Douglas A. Melton combines subjects such as SOX2, Induced pluripotent stem cell and Cell growth with his study of Cellular differentiation.

He most often published in these fields:

  • Cell biology (71.30%)
  • Stem cell (31.72%)
  • Xenopus (19.03%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (71.30%)
  • Stem cell (31.72%)
  • Induced pluripotent stem cell (14.50%)

In recent papers he was focusing on the following fields of study:

Douglas A. Melton spends much of his time researching Cell biology, Stem cell, Induced pluripotent stem cell, Cell and Cell type. His studies deal with areas such as Enteroendocrine cell, In vitro and Pancreas as well as Cell biology. His Stem cell study integrates concerns from other disciplines, such as Cellular differentiation, Mtor signaling, MTOR Protein, Transplantation and Islet.

His Induced pluripotent stem cell study combines topics in areas such as Type 1 diabetes, Beta cell, Immune system and Cancer research. His work deals with themes such as Gene expression and Immunology, which intersect with Cell. The concepts of his Cell type study are interwoven with issues in Extracellular, Proinsulin, Glucagon and In vivo.

Between 2016 and 2021, his most popular works were:

  • Charting cellular identity during human in vitro β-cell differentiation. (137 citations)
  • Charting cellular identity during human in vitro β-cell differentiation. (137 citations)
  • YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells. (67 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cellular differentiation

The scientist’s investigation covers issues in Cell biology, Induced pluripotent stem cell, Cell type, Stem cell and Enteroendocrine cell. He has included themes like Amino acid and Pancreas in his Cell biology study. His work in Induced pluripotent stem cell tackles topics such as Transplantation which are related to areas like Immunosuppression, Islet and Fibrosis.

His studies in Cell type integrate themes in fields like Phenotype, Gene expression, Systems biology and Genomics. His research is interdisciplinary, bridging the disciplines of Cellular differentiation and Stem cell. The study incorporates disciplines such as In vitro, Regenerative medicine, Intensive care medicine and Single-cell analysis in addition to Cellular differentiation.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

D.A. Melton;P.A. Krieg;M.R. Rebagliati;T. Maniatis.
Nucleic Acids Research (1984)

7034 Citations

Core transcriptional regulatory circuitry in human embryonic stem cells.

Laurie A. Boyer;Tong Ihn Lee;Megan F. Cole;Sarah E. Johnstone.
Cell (2005)

5263 Citations

A molecular mechanism for the effect of lithium on development

Peter S. Klein;Douglas A. Melton.
Proceedings of the National Academy of Sciences of the United States of America (1996)

2859 Citations

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

Yuval Dor;Juliana Brown;Olga I. Martinez;Douglas A. Melton.
Nature (2004)

2665 Citations

Control of developmental regulators by Polycomb in human embryonic stem cells.

Tong Ihn Lee;Richard G. Jenner;Laurie A. Boyer;Matthew G. Guenther.
Cell (2006)

2597 Citations

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

Qiao Zhou;Juliana Brown;Andrew Kanarek;Jayaraj Rajagopal.
Nature (2008)

2285 Citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

Miguel Ramalho-Santos;Soonsang Yoon;Yumi Matsuzaki;Richard C. Mulligan.
Science (2002)

2019 Citations

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

Danwei Huangfu;René Maehr;Wenjun Guo;Astrid Eijkelenboom;Astrid Eijkelenboom.
Nature Biotechnology (2008)

1990 Citations

Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs

P.A. Krieg;D.A. Melton.
Nucleic Acids Research (1984)

1850 Citations

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Danwei Huangfu;Kenji Osafune;René Maehr;Wenjun Guo.
Nature Biotechnology (2008)

1791 Citations

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