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Douglas A. Melton

Douglas A. Melton

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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
141
Citations
98161
World Ranking
116
National Ranking
77

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 1995 - Fellow of the American Academy of Arts and Sciences
  • 1995 - Member of the National Academy of Sciences

Overview

Douglas A. Melton is affiliated with Harvard University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these, they focus notably on Surgery, Molecular Biology, Genetics, Endocrinology, Diabetes and Metabolism, and Cell Biology.

Their main topics of study relate to Pancreatic function and diabetes, Diabetes and associated disorders, Diabetes Management and Research, Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Metabolism, Diabetes, and Cancer, as well as Genetics and Neurodevelopmental Disorders.

Recent publications include:

  • "A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion" (2020), published in Cell Metabolism
  • "Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis" (2020), published in Cell Reports
  • "A method for the generation of human stem cell-derived alpha cells" (2020), published in Nature Communications
  • "Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes" (2020), published in Nature Metabolism
  • "The promise of stem cell-derived islet replacement therapy" (2021), published in Diabetologia

Common venues for publication include Diabetes, Transplantation, Cell Metabolism, Cell Reports, and Nature Communications.

Among frequent co-authors collaborating with Douglas A. Melton are Jennifer Hyoje-Ryu Kenty, Dario Gerace, Elad Sintov, Kyle R. Boulanger, and Aharon Helman.

Douglas A. Melton received recognition as a Fellow of the American Academy of Arts and Sciences as well as membership in the National Academy of Sciences, both awarded in 1995.

Best Publications

  • Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

    D.A. Melton;P.A. Krieg;M.R. Rebagliati;T. Maniatis

  • Core transcriptional regulatory circuitry in human embryonic stem cells.

    Laurie A. Boyer;Tong Ihn Lee;Megan F. Cole;Sarah E. Johnstone

  • A molecular mechanism for the effect of lithium on development

    Peter S. Klein;Douglas A. Melton

  • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

    Yuval Dor;Juliana Brown;Olga I. Martinez;Douglas A. Melton

  • Control of developmental regulators by Polycomb in human embryonic stem cells.

    Tong Ihn Lee;Richard G. Jenner;Laurie A. Boyer;Matthew G. Guenther

  • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

    Qiao Zhou;Juliana Brown;Andrew Kanarek;Jayaraj Rajagopal

  • Generation of functional human pancreatic β cells in vitro

    Felicia W. Pagliuca;Jeffrey R. Millman;Mads Gürtler;Michael Segel

  • "Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

    Miguel Ramalho-Santos;Soonsang Yoon;Yumi Matsuzaki;Richard C. Mulligan

  • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

    Danwei Huangfu;René Maehr;Wenjun Guo;Astrid Eijkelenboom;Astrid Eijkelenboom

  • Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs

    P.A. Krieg;D.A. Melton

  • Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

    Danwei Huangfu;Kenji Osafune;René Maehr;Wenjun Guo

  • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors.

    Guoqiang Gu;Jolanta Dubauskaite;Douglas A. Melton

  • Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

    Maya Schuldiner;Ofra Yanuka;Joseph Itskovitz-Eldor;Douglas A. Melton

  • Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells

    Chad A. Cowan;Jocelyn Atienza;Douglas A. Melton;Kevin Eggan

  • A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.

    Maayan Baron;Adrian Veres;Samuel L. Wolock;Aubrey L. Faust

  • Induction of Pancreatic Differentiation by Signals from Blood Vessels

    Eckhard Lammert;Ondine Cleaver;Douglas Melton

  • Derivation of embryonic stem-cell lines from human blastocysts.

    Chad A. Cowan;Irinha Klimanskaya;Jill Mcmahon;Jocelyn Atienza

  • Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

    Ali Hemmati-Brivanlou;Olivia G. Kelly;Douglas A. Melton

  • Marked differences in differentiation propensity among human embryonic stem cell lines

    Kenji Osafune;Kenji Osafune;Leslie Caron;Malgorzata Borowiak;Malgorzata Borowiak;Rita J Martinez;Rita J Martinez

  • In vitro RNA synthesis with SP6 RNA polymerase.

    P A Krieg;D A Melton

Frequent Co-Authors

Ben Z. Stanger
Ben Z. Stanger University of Pennsylvania
Yuval Dor
Yuval Dor Hebrew University of Jerusalem
Chad A. Cowan
Chad A. Cowan Beth Israel Deaconess Medical Center
John M. Wozney
John M. Wozney Pfizer (Canada)
Vicki Rosen
Vicki Rosen Harvard University
Kevin Eggan
Kevin Eggan Harvard University
Sergei Y. Sokol
Sergei Y. Sokol Icahn School of Medicine at Mount Sinai
Matthias Hebrok
Matthias Hebrok University of California, San Francisco
Pardis C. Sabeti
Pardis C. Sabeti Harvard University

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