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D-Index & Metrics

Molecular Biology

D-Index
96
Citations
30649
World Ranking
615
National Ranking
51

Overview

James C. Smith is affiliated with The Francis Crick Institute in the United Kingdom. Their research focuses primarily on the field of Biochemistry, Genetics and Molecular Biology, with a particular emphasis on Molecular Biology. Other significant areas include Pulmonary and Respiratory Medicine, Cell Biology, Electrical and Electronic Engineering, and Genetics.

Their recent research contributions cover a variety of topics such as Congenital heart defects research, Epigenetics and DNA Methylation, Wnt/β-catenin signaling in development and cancer, Zebrafish Biomedical Research Applications, Cell Image Analysis Techniques, Single-cell and spatial transcriptomics, and Electric Motor Design and Analysis.

Frequent co-authors in James C. Smith's work include Dirk M. Elston, Jane M. Grant-Kels, Richard Dobson, Jeffrey D. Bernhard, and B.H. Thiers.

James C. Smith has published extensively in several scientific journals. Their frequent publication venues are:

  • Journal of the American Academy of Dermatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Wellcome Open Research
  • PLoS Biology
  • JCI Insight

Recent papers by James C. Smith include:

  • "Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak," 2021, PLoS Biology
  • "Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva," 2021, JCI Insight
  • "In vitro cellular reprogramming to model gonad development and its disorders," 2023, Science Advances
  • "Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13," 2020, Nature Communications
  • "Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells," 2023, Cell Reports Methods

Best Publications

  • Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction.

    J.C. Smith;B.M.J. Price;J.B.A. Green;D. Weigel

  • Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation.

    Carl-Philipp Heisenberg;Masazumi Tada;Gerd-Jörg Rauch;Leonor Saúde

  • Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway

    Masazumi Tada;J. C. Smith

  • Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.

    J C Smith;B M Price;K Van Nimmen;Danny Huylebroeck

  • Controlling morpholino experiments: don't stop making antisense

    Judith S. Eisen;James C. Smith

  • Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development

    L. Dale;G. Howes;B. M. J. Price;J. C. Smith

  • Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.

    H Yamashita;P ten Dijke;D Huylebroeck;T K Sampath

  • Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

    Jeremy B. A. Green;J. C. Smith

  • SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.

    Kristin Verschueren;Jacques E. Remacle;Clara Collart;Clara Collart;Harry Kraft;Harry Kraft

  • Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm

    Jeremy B.A. Green;Helen V. New;J.C. Smith

  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation

    C. M. Jones;M. R. Kuehn;B. L. M. Hogan;J. C. Smith

  • BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

    Andreia S. Bernardo;Tiago Faial;Tiago Faial;Lucy Gardner;Kathy K. Niakan

  • Wise, a context-dependent activator and inhibitor of Wnt signalling

    Nobue Itasaki;C Michael Jones;Sara Mercurio;Alison Rowe

  • Placentation defects are highly prevalent in embryonic lethal mouse mutants.

    Vicente Perez-Garcia;Vicente Perez-Garcia;Elena Fineberg;Elena Fineberg;Robert Wilson;Alexander Murray;Alexander Murray

  • Nomenclature: Vertebrate Mediators of TGFβ Family Signals

    Rik Derynck;William M Gelbart;Richard M Harland;Carl-Henrik Heldin

  • New mode of DNA binding of multi‐zinc finger transcription factors: δEF1 family members bind with two hands to two target sites

    Jacques E. Remacle;Harry Kraft;Walter Lerchner;Gunther Wuytens

  • Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm.

    F.L. Conlon;S.G. Sedgwick;K.M. Weston;J.C. Smith

  • Mesoderm formation in response to Brachyury requires FGF signalling

    S. Schulte-Merker;J.C. Smith

  • Mesoderm induction and mesoderm-inducing factors in early amphibian development.

    J. C. Smith

  • A mesoderm-inducing factor is produced by a Xenopus cell line

    J.C. Smith

Frequent Co-Authors

Frederick J. Livesey
Frederick J. Livesey University College London
Rosa S. P. Beddington
Rosa S. P. Beddington Medical Research Council
Janet Heasman
Janet Heasman Cincinnati Children's Hospital Medical Center
Nancy Papalopulu
Nancy Papalopulu University of Manchester
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Timothy J. Mohun
Timothy J. Mohun The Francis Crick Institute
Christopher Wylie
Christopher Wylie Cincinnati Children's Hospital Medical Center
Myriam Hemberger
Myriam Hemberger University of Calgary
David J. Adams
David J. Adams Wellcome Sanger Institute

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