World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
38669
World Ranking
2510
National Ranking
183

Research.com Recognitions

  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2002 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Human Genetics and Molecular Medicine
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Christof Niehrs is affiliated with the German Cancer Research Center in Germany. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, genetics, oncology, surgery, and cancer research.

The scientist's work covers several main topics including:

  • Wnt/β-catenin signaling in development and cancer
  • Epigenetics and DNA methylation
  • Cancer-related gene regulation
  • RNA modifications and cancer
  • Genetic and kidney cyst diseases
  • Renal and related cancers
  • DNA repair mechanisms

Christof Niehrs has published extensively in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, eLife, Nature Structural & Molecular Biology, and Cells and Development.

Among recent papers attributed to or connected with their research area are:

  • "Regulatory R-loops as facilitators of gene expression and genome stability," 2020, Nature Reviews Molecular Cell Biology
  • "Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning," 2021, Nucleic Acids Research
  • "The origin of genomic N6-methyl-deoxyadenosine in mammalian cells," 2020, Nature Chemical Biology
  • "DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites," 2023, Clinical Epigenetics
  • "The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila," 2020, EMBO Reports

Frequent co-authors working with Christof Niehrs include Michael U. Musheev, Carina Seidl, Hye-Yoon Lee, Rui Sun, and Fabio Da Silva, reflecting collaborations across multiple disciplines related to molecular biology and cancer research.

Niehrs has received various recognitions within scientific communities, including:

  • Fellow of the American Academy of Arts and Sciences (2016)
  • Member of the German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften (2002) in Human Genetics and Molecular Medicine
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

    Andrei Glinka;Wei Wu;Hajo Delius;A. Paula Monaghan

  • The complex world of WNT receptor signalling

    Christof Niehrs

  • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

    Bingyu Mao;Wei Wu;Yan Li;Dana Hoppe

  • Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.

    Bingyu Mao;Wei Wu;Gary Davidson;Joachim Marhold

  • Function and biological roles of the Dickkopf family of Wnt modulators

    C Niehrs

  • Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.

    Josipa Bilić;Ya Lin Huang;Ya Lin Huang;Gary Davidson;Gary Davidson;Timo Zimmermann

  • Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

    Darya Onichtchouk;Ye Guang Chen;Roland Dosch;Volker Gawantka

  • Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation

    Guillermo Barreto;Andrea Schäfer;Joachim Marhold;Dirk Stach

  • Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

    Gary Davidson;Wei Wu;Jinlong Shen;Josipa Bilic

  • Fibroblast growth factor signaling during early vertebrate development.

    Ralph T. Böttcher;Christof Niehrs

  • Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

    Mahua Mukhopadhyay;Svetlana Shtrom;Concepcion Rodriguez-Esteban;Lan Chen

  • Secreted and Transmembrane Wnt Inhibitors and Activators

    Cristina Maria Cruciat;Christof Niehrs

  • A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning in Xenopus

    Clemens Kiecker;Christof Niehrs

  • LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

    Andrei Glinka;Christine Dolde;Nadine Kirsch;Ya Lin Huang

  • Requirement of Prorenin Receptor and Vacuolar H+-ATPase–Mediated Acidification for Wnt Signaling

    Cristina Maria Cruciat;Bisei Ohkawara;Sergio P. Acebron;Emil Karaulanov

  • Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

    Frederic Morvan;Kim Boulukos;Philippe Clément-Lacroix;Sergio Roman Roman

  • R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis

    Olga Kazanskaya;Andrei Glinka;Ivan del Barco Barrantes;Peter Stannek

  • ANTAGONIZING THE SPEMANN ORGANIZER : ROLE OF THE HOMEOBOX GENE XVENT-1

    Volker Gawantka;Hajo Delius;Kirsten Hirschfeld;Claudia Blumenstock

  • Synexpression groups in eukaryotes.

    Christof Niehrs;Nicolas Pollet

  • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

    Bingyu Mao;Christof Niehrs

Frequent Co-Authors

Michael Boutros
Michael Boutros German Cancer Research Center
Wieland B. Huttner
Wieland B. Huttner Max Planck Society
Ken W.Y. Cho
Ken W.Y. Cho University of California, Irvine
Naoto Ueno
Naoto Ueno National Institute for Basic Biology
Heiner Westphal
Heiner Westphal National Institutes of Health
Qingbo Xu
Qingbo Xu King's College London
Yanhua Hu
Yanhua Hu King's College London
Thomas W. Holstein
Thomas W. Holstein Heidelberg University
Martin Vingron
Martin Vingron Max Planck Society

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Christof Niehrs

Trending Scientists