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Patrick P.L. Tam

Patrick P.L. Tam

D-Index & Metrics

Molecular Biology

D-Index
90
Citations
28017
World Ranking
740
National Ranking
20

Research.com Recognitions

  • 2011 - Fellow of the Royal Society, United Kingdom

Overview

Patrick P.L. Tam is a researcher affiliated with the University of Sydney in Australia. Their primary field of study is Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Genetics, Biophysics, Surgery, and Cell Biology.

The main topics covered in their research include pluripotent stem cells research, single-cell and spatial transcriptomics, congenital heart defects research, CRISPR and genetic engineering, renal and related cancers, cell image analysis techniques, and genomics and chromatin dynamics.

Among their recent publications are the following papers:

  • Early human embryonic development: Blastocyst formation to gastrulation (2022) in Developmental Cell
  • Opportunities and challenges with stem cell-based embryo models (2021) in Stem Cell Reports
  • Cellular diversity and lineage trajectory: insights from mouse single cell transcriptomes (2020) in Development
  • TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation (2021) in eLife
  • Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity (2020) in Cell Systems

Frequent co-authors collaborating with Patrick P.L. Tam include:

  • Pierre Osteil
  • Naihe Jing
  • Guangdun Peng
  • Pengyi Yang
  • V. Pragathi Masamsetti

The researcher has published extensively in several venues, with notable numbers of publications in:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Methods in molecular biology
  • Developmental Cell
  • Stem Cell Reports

Patrick P.L. Tam was awarded the Fellow of the Royal Society (United Kingdom) in 2011, recognizing their contributions to science.

Best Publications

  • SOX9 directly regulates the type-II collagen gene.

    Donald M. Bell;Keith K.H. Leung;Susan C. Wheatley;Ling Jim Ng

  • Depletion of definitive gut endoderm in Sox17-null mutant mice.

    Masami Kanai-Azuma;Yoshiakira Kanai;Jacqueline M. Gad;Youichi Tajima

  • SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

    Ling-Jim Ng;Susan Wheatley;George E.O Muscat;John Conway-Campbell

  • Gene function in mouse embryogenesis: get set for gastrulation.

    Patrick P. L. Tam;David A. F. Loebel

  • Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse.

    Janet Rossant;Patrick P. L. Tam

  • Mouse gastrulation: the formation of a mammalian body plan

    Patrick P.L Tam;Richard R Behringer

  • Mutations of CDKL5 Cause a Severe Neurodevelopmental Disorder with Infantile Spasms and Mental Retardation

    Linda S. Weaving;John Christodoulou;John Christodoulou;Sarah L. Williamson;Sarah L. Williamson;Kathie L. Friend

  • The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo.

    Patrick P.L. Tam;Sheila X. Zhou

  • Cranial paraxial mesoderm and neural crest cells of the mouse embryo: co-distribution in the craniofacial mesenchyme but distinct segregation in branchial arches.

    Paul A. Trainor;Patrick P. L. Tam

  • The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo

    Simon J. Kinder;Tania E. Tsang;Gabriel A. Quinlan;Anna Katerina Hadjantonakis

  • Regulation of Murine Telomere Length by Rtel: An Essential Gene Encoding a Helicase-like Protein

    Hao Ding;Mike Schertzer;Xiaoli Wu;Marina Gertsenstein

  • Extrinsic regulation of pluripotent stem cells

    Martin F. Pera;Patrick P. L. Tam;Patrick P. L. Tam

  • Lineage choice and differentiation in mouse embryos and embryonic stem cells.

    David A.F Loebel;Catherine M Watson;R.Andrea De Young;Patrick P.L Tam

  • The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation

    Patrick P. L. Tam;Maala Parameswaran;Simon J. Kinder;Ron P. Weinberger

  • The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm

    Simon J. Kinder;Tania E. Tsang;Maki Wakamiya;Hiroshi Sasaki

  • X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.

    Takashi Sado;Martin H Fenner;Seong-Seng Tan;Patrick Tam

  • The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

    Yoji Kojima;Keren Kaufman-Francis;Joshua B. Studdert;Kirsten A. Steiner

  • Establishment of porcine and human expanded potential stem cells

    Xuefei Gao;Xuefei Gao;Monika Nowak-Imialek;Monika Nowak-Imialek;Xi Chen;Dongsheng Chen

  • The UTX Gene Escapes X Inactivation in Mice and Humans

    Andy Greenfield;Laura Carrel;David J. Pennisi;Christophe Philippe

  • Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.

    Kenneth Soo;Meredith P. O'Rourke;Poh Lynn Khoo;Kirsten A. Steiner

Frequent Co-Authors

John Christodoulou
John Christodoulou University of Melbourne
Seong-Seng Tan
Seong-Seng Tan University of Melbourne
Richard R. Behringer
Richard R. Behringer The University of Texas MD Anderson Cancer Center
Jing-Dong J. Han
Jing-Dong J. Han Peking University
Andras Nagy
Andras Nagy Lunenfeld-Tanenbaum Research Institute
Kathryn S. E. Cheah
Kathryn S. E. Cheah University of Hong Kong
Janet Rossant
Janet Rossant University of Toronto
Paul A. Trainor
Paul A. Trainor University of Kansas
Joseph E. Powell
Joseph E. Powell Garvan Institute of Medical Research
Peter Koopman
Peter Koopman University of Queensland

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