His primary scientific interests are in Genetics, Cell biology, Gene, X chromosome and Missense mutation. Genetics is often connected to Epilepsy in his work. His work carried out in the field of Cell biology brings together such families of science as Corticotropic cell, Cell type and Cellular differentiation.
His work on RNA-binding protein, Messenger RNA and Phenotype as part of his general Gene study is frequently connected to Nonsense-mediated decay, thereby bridging the divide between different branches of science. His X chromosome research incorporates elements of Molecular biology, Cell nucleus, Zinc finger and Gene mutation. His work in Mutation addresses subjects such as Bone morphogenetic protein 4, which are connected to disciplines such as Internal medicine and Endocrinology.
His primary areas of study are Genetics, Cell biology, Gene, Endocrinology and Internal medicine. In most of his Genetics studies, his work intersects topics such as Epilepsy. His study in Cell biology is interdisciplinary in nature, drawing from both Embryonic stem cell, Regulation of gene expression, Cellular differentiation and Anatomy.
Paul Q. Thomas works mostly in the field of Cellular differentiation, limiting it down to concerns involving Progenitor cell and, occasionally, Pituitary gland and Cell type. The Anatomy study combines topics in areas such as Gastrulation and Endoderm. His studies deal with areas such as Homing and Bioinformatics as well as Gene.
Paul Q. Thomas mainly focuses on CRISPR, Gene, Genetics, Gene drive and Allele. His work on Cas9 and Genome editing as part of general CRISPR research is frequently linked to Synthetic gene, thereby connecting diverse disciplines of science. He has researched Gene in several fields, including Precision medicine and Bioinformatics.
His research ties Epilepsy and Genetics together. His work is dedicated to discovering how Disorders of sex development, Regulation of gene expression are connected with Testis determining factor and Mutation and other disciplines. His Conditional gene knockout research focuses on Embryonic stem cell and how it relates to Cell biology.
Paul Q. Thomas spends much of his time researching Gene drive, Allele, CRISPR, Genetics and Cas9. His study explores the link between Allele and topics such as Computational biology that cross with problems in Human genetics and Mutagenesis. His CRISPR study is related to the wider topic of Gene.
His Genetics study frequently links to adjacent areas such as Epilepsy. His work deals with themes such as Cleavage, Transgene, Subgenomic mRNA, Stereochemistry and Genome editing, which intersect with Cas9. His study looks at the relationship between Protocadherin and topics such as Mutation, which overlap with Cell biology.
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
Mehul T. Dattani;Juan-Pedro Martinez-Barbera;Paul Q. Thomas;Joshua M. Brickman.
Nature Genetics (1998)
Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
Paul Thomas;Rosa Beddington.
Current Biology (1996)
Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
Paul Thomas;A. Brown;R. S.P. Beddington.
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.
J.P. Martinez Barbera;M. Clements;P. Thomas;T. Rodriguez.
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence.
Sabina Benko;Judy A. Fantes;Jeanne Amiel;Dirk Jan Kleinjan.
Nature Genetics (2009)
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.
Leanne M. Dibbens;Leanne M. Dibbens;Patrick S. Tarpey;Kim Hynes;Kim Hynes;Marta A. Bayly.
Nature Genetics (2008)
GDNF is a chemoattractant for enteric neural cells
H. M. Young;C. J. Hearn;P. G. Farlie;A. J. Canty.
Developmental Biology (2001)
Heterozygous HESX1 mutations associated with isolated congenital pituitary hypoplasia and septo-optic dysplasia
Paul Q. Thomas;Mehul T. Dattani;Mehul T. Dattani;Joshua M. Brickman;David McNay.
Human Molecular Genetics (2001)
Transcription Factor SOX3 Is Involved in X-Linked Mental Retardation with Growth Hormone Deficiency
Frederic Laumonnier;Nathalie Ronce;Ben C.J. Hamel;Paul Thomas.
American Journal of Human Genetics (2002)
Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism
Kathryn S. Woods;Maria Cundall;James Turton;Karine Rizotti.
American Journal of Human Genetics (2005)
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