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Genetics

D-Index
96
Citations
49220
World Ranking
852
National Ranking
119

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Robin Lovell-Badge is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Medicine. Key subfields include Molecular Biology, Genetics, Reproductive Medicine, Public Health, Environmental and Occupational Health, and Oncology.

The scientist's work concentrates on areas such as Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Reproductive Biology and Fertility, Animal Genetics and Reproduction, Sexual Differentiation and Disorders, Renal and Related Cancers, Cancer Cells and Metastasis, and Neurogenesis and Neuroplasticity Mechanisms.

Robin Lovell-Badge has contributed to numerous publications, frequently appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Science Advances, Development, and Nature.

Significant recent papers include:

  • ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update, 2021, Stem Cell Reports
  • Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics, 2021, Proceedings of the National Academy of Sciences
  • Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene, 2020, Proceedings of the National Academy of Sciences
  • The −KTS splice variant of WT1 is essential for ovarian determination in mice, 2023, Science
  • In the chick embryo, estrogen can induce chromosomally male ZZ left gonad epithelial cells to form an ovarian cortex, which supports oogenesis, 2020, Development

Frequent collaborators include:

  • Karine Rizzoti
  • Christophe Galichet
  • Verónica Moncho-Amor
  • Probir Chakravarty
  • Roberta Migale

Throughout their career, Robin Lovell-Badge has received distinctions such as Fellow of the American Association for the Advancement of Science (AAAS) in 2018, Fellow of the Royal Society, United Kingdom in 2001, Fellow of The Academy of Medical Sciences, United Kingdom, and Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif

    Sinclair Ah;Berta P;Berta P;Palmer Ms;Hawkins

  • Multipotent cell lineages in early mouse development depend on SOX2 function

    Ariel A. Avilion;Silvia K. Nicolis;Larysa H. Pevny;Lidia Perez

  • Male development of chromosomally female mice transgenic for Sry

    Peter Koopman;John Gubbay;Nigel Vivian;Peter Goodfellow

  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

    John Gubbay;Jérôme Collignon;Peter Koopman;Blanche Capel

  • Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

    Ryohei Sekido;Robin Lovell-Badge

  • Circular transcripts of the testis-determining gene Sry in adult mouse testis

    Blanche Capel;Amanda Swain;Silvia Nicolis;Adam Hacker

  • Expression of a candidate sex-determining gene during mouse testis differentiation

    Peter Koopman;Andrea Münsterberg;Blanche Capel;Nigel Vivian

  • Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation

    N. Henriette Uhlenhaut;Susanne Jakob;Katrin Anlag;Tobias Eisenberger

  • Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

    Sara Morais da Silva;Adam Hacker;Adam Hacker;Vince Harley;Vince Harley;Peter Goodfellow

  • Expression of Sry, the mouse sex determining gene

    Adam Hacker;Blanche Capel;Peter Goodfellow;Robin Lovell-Badge

  • Sox genes find their feet

    Larysa H Pevny;Robin Lovell-Badge

  • Dax1 antagonizes Sry action in mammalian sex determination

    Amanda Swain;Veronica Narvaez;Veronica Narvaez;Paul Burgoyne;Giovanna Camerino

  • Generation of purified neural precursors from embryonic stem cells by lineage selection

    Meng Li;Larysa Pevny;Robin Lovell-Badge;Austin Smith

  • Targeted Mutagenesis of the Endogenous Mouse Mis Gene Promoter: In Vivo Definition of Genetic Pathways of Vertebrate Sexual Development

    Nelson A Arango;Robin Lovell-Badge;Richard R Behringer

  • A role for SOX1 in neural determination

    Larysa H. Pevny;Shantini Sockanathan;Marysia Placzek;Robin Lovell-Badge

  • Sox2 is required for sensory organ development in the mammalian inner ear

    Amy E. Kiernan;Anna L. Pelling;Keith K. H. Leung;Anna S. P. Tang

  • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination

    Yuna Kim;Akio Kobayashi;Ryohei Sekido;Leo DiNapoli

  • A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2

    Jérôme Collignon;Shanthini Sockanathan;Adam Hacker;Michel Cohen-Tannoudji

  • SRY, like HMG1, recognizes sharp angles in DNA.

    Simona Ferrari;Vincent R. Harley;Andrea Pontiggia;Peter N. Goodfellow

  • Expression of the mouse anti-müllerian hormone gene suggests a role in both male and female sexual differentiation.

    Andrea Munsterberg;Robin Lovell-Badge

Frequent Co-Authors

Vincent R. Harley
Vincent R. Harley Hudson Institute of Medical Research
Peter Koopman
Peter Koopman University of Queensland
Blanche Capel
Blanche Capel Duke University
Kathryn S. E. Cheah
Kathryn S. E. Cheah University of Hong Kong
Hisato Kondoh
Hisato Kondoh Kyoto Sangyo University
Paul Thomas
Paul Thomas University of Adelaide
Paul S. Burgoyne
Paul S. Burgoyne Medical Research Council
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute
Andrew H. Sinclair
Andrew H. Sinclair University of Melbourne

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