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Genetics

D-Index
70
Citations
15882
World Ranking
2284
National Ranking
76

Overview

Vincent R. Harley is affiliated with the Hudson Institute of Medical Research in Australia. Their research spans several interconnected fields primarily within biochemistry, genetics, and molecular biology, along with significant contributions to medicine. The main areas of study include genetics, molecular biology, reproductive medicine, urology, and public health, environmental and occupational health.

The scientist's research focuses extensively on genetic and clinical aspects related to sex determination and chromosomal abnormalities. They have explored sexual differentiation and disorders, sperm and testicular function, as well as urological disorders and treatments. Further topics include animal genetics and reproduction, genetics and neurodevelopmental disorders, and considerations of sex and gender in healthcare.

Some of the recent papers by Vincent R. Harley demonstrate engagement with both fundamental biological processes and clinical applications:

  • "SOX9 in organogenesis: shared and unique transcriptional functions" (2022), published in Cellular and Molecular Life Sciences
  • "Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex Determination" (2021), published in Genes
  • "Genetic control of typical and atypical sex development" (2023), published in Nature Reviews Urology
  • "Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype" (2024), published in Nature Communications
  • "Analysis of variants in GATA4 and FOG2/ZFPM2 demonstrates benign contribution to 46,XY disorders of sex development" (2020), published in Molecular Genetics & Genomic Medicine

The scientist collaborates frequently with colleagues including Stefan Bagheri-Fam, Janelle Ryan, Zhenhua Ming, Emily R. Frost, and Brittany Croft. These collaborations indicate a network of research partners contributing to their extensive academic output.

Vincent R. Harley has published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Clinical Genetics, Frontiers in Cell and Developmental Biology, Cellular and Molecular Life Sciences, and Genes. These publication venues reflect a focus on both preprint dissemination and peer-reviewed journals in genetics and developmental biology.

Best Publications

  • SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene.

    V Lefebvre;W Huang;V R Harley;P N Goodfellow

  • Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

    Sara Morais da Silva;Adam Hacker;Adam Hacker;Vince Harley;Vince Harley;Peter Goodfellow

  • SRY, like HMG1, recognizes sharp angles in DNA.

    Simona Ferrari;Vincent R. Harley;Andrea Pontiggia;Peter N. Goodfellow

  • DNA binding activity of recombinant SRY from normal males and XY females

    VR Harley;DI Jackson;PJ Hextall;Hawkins

  • Definition of a consensus DNA binding site for SRY

    Vincent R. Harley;Robin Lovell-Badge;Peter N. Goodfellow

  • Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY

    Phoebe Dewing;Charleston W K Chiang;Kevin Sinchak;Helena Sim

  • Sex-reversing mutations affect the architecture of SRY-DNA complexes.

    A Pontiggia;R Rimini;V R Harley;P N Goodfellow

  • Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort

    Stefanie Eggers;Simon Sadedin;Jocelyn A. van den Bergen;Gorjana Robevska

  • BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage

    Ryan B. Rountree;Michael Schoor;Hao Chen;Melissa E Marks

  • The Molecular Action and Regulation of the Testis-Determining Factors, SRY (Sex-Determining Region on the Y Chromosome) and SOX9 [SRY-Related High-Mobility Group (HMG) Box 9]

    Vincent R. Harley;Michael J. Clarkson;Anthony Argentaro

  • Identification of SOX3 as an XX male sex reversal gene in mice and humans

    Edwina Sutton;James Hughes;Stefan John White;Ryohei Sekido

  • Androgen Receptor Repeat Length Polymorphism Associated with Male-to-Female Transsexualism

    Lauren May Hare;Pascal Bernard;Francisco J Sanchez;Paul N Baird

  • The DNA-binding specificity of SOX9 and other SOX proteins

    Sabine Mertin;Sharon G. McDowall;Vincent R. Harley

  • Summary of Consensus Statement on Intersex Disorders and Their Management

    Christopher P. Houk;Ieuan A. Hughes;S. Faisal Ahmed;Peter A. Lee

  • Disorders of sex development: new genes, new concepts.

    Makoto Ono;Vincent Russel Harley

  • Dimerization of SOX9 is required for chondrogenesis, but not for sex determination

    Pascal Bernard;Paisu Tang;Siyuan Liu;Phoebe Dewing

  • Endothelial cell migration directs testis cord formation.

    Alexander N. Combes;Dagmar Wilhelm;Tara Davidson;Elisabetta Dejana

  • Disruption of a long distance regulatory region upstream of SOX9 in isolated disorders of sex development

    Sabina Benko;Christopher T Gordon;Delphine Mallet;Rajini Sreenivasan

  • SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes

    Thomas Aigner;Pia Margarethe Gebhard;Erik Schmid;Brigitte Bau

  • Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

    Vincent R. Harley;Sharon Layfield;Claire L. Mitchell;Jade K. Forwood

Frequent Co-Authors

Peter Koopman
Peter Koopman University of Queensland
Andrew H. Sinclair
Andrew H. Sinclair University of Melbourne
Eric Vilain
Eric Vilain George Washington University
Robin Lovell-Badge
Robin Lovell-Badge The Francis Crick Institute
Dagmar Wilhelm
Dagmar Wilhelm University of Melbourne
John M. Hutson
John M. Hutson Royal Children's Hospital
Josephine Bowles
Josephine Bowles University of Queensland
Peter J. Hudson
Peter J. Hudson Pennsylvania State University
Leendert H. J. Looijenga
Leendert H. J. Looijenga Princess Máxima Center

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