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Biology and Biochemistry

D-Index
75
Citations
17688
World Ranking
5394
National Ranking
348

Overview

Hiroshi Asahara is affiliated with Tokyo Medical and Dental University in Japan. Their research spans key areas within biochemistry, genetics, molecular biology, and medicine, with specific contributions to subfields such as molecular biology, cancer research, orthopedics and sports medicine, rheumatology, and surgery.

The scientist's work encompasses a variety of topics related to molecular mechanisms and disease regulation. These include:

  • Cancer-related molecular mechanisms research
  • Tendon structure and treatment
  • RNA modifications and cancer
  • Osteoarthritis treatment and mechanisms
  • MicroRNA in disease regulation
  • RNA research and splicing
  • Circular RNAs in diseases

Asahara has authored several notable papers, illustrating a research focus on tendon and cartilage biology, as well as molecular regulation related to inflammatory arthritis and osteoarthritis. Selected recent publications include:

  • "Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis," 2020, Nature Reviews Rheumatology
  • "Cartilage Homeostasis and Osteoarthritis," 2022, International Journal of Molecular Sciences
  • "Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis," 2021, Nature Communications
  • "Regulation of tendon and ligament differentiation," 2020, Bone
  • "The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance," 2022, Science Translational Medicine

The frequent venues in which Asahara publishes include bioRxiv (Cold Spring Harbor Laboratory), Osteoarthritis and Cartilage, Nature Communications, Science Translational Medicine, and Frontiers in Cell and Developmental Biology. These outlets reflect an emphasis on both foundational molecular biology and clinical aspects of musculoskeletal diseases.

Collaborative work is evident in Asahara's frequent coauthors, who contribute to advancing research in related fields. Key collaborators have included Tomoki Chiba, Ryota Kurimoto, Takahide Matsushima, Ryo Nakamichi, and Yoshiaki Ito.

Best Publications

  • Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue

    Tomoyuki Nakasa;Shigeru Miyaki;Atsuko Okubo;Megumi Hashimoto

  • MicroRNA-140 plays dual roles in both cartilage development and homeostasis

    Shigeru Miyaki;Tempei Sato;Atsushi Inoue;Shuhei Otsuki

  • MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

    Shigeru Miyaki;Tomoyuki Nakasa;Shuhei Otsuki;Shawn P. Grogan

  • The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

    Harukazu Suzuki;Alistair R.R. Forrest;Erik Van Nimwegen;Carsten O. Daub

  • A Transcriptional Switch Mediated by Cofactor Methylation

    Wei Xu;Hongwu Chen;Keyong Du;Hiroshi Asahara

  • Expression of MicroRNA-146a in osteoarthritis cartilage.

    Keiichiro Yamasaki;Tomoyuki Nakasa;Shigeru Miyaki;Masakazu Ishikawa

  • Smad3 Induces Chondrogenesis through the Activation of SOX9 via CREB-binding Protein/p300 Recruitment

    Takayuki Furumatsu;Masanao Tsuda;Noboru Taniguchi;Yoshitaka Tajima

  • Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

    Kojiro Sato;Ayako Suematsu;Tomoki Nakashima;Sayaka Takemoto-Kimura

  • Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis

    Shawn P Grogan;Shawn P Grogan;Shigeru Miyaki;Hiroshi Asahara;Darryl D D'Lima;Darryl D D'Lima

  • The Mohawk homeobox gene is a critical regulator of tendon differentiation

    Yoshiaki Ito;Naoya Toriuchi;Teruhito Yoshitaka;Hiroe Ueno-Kudoh

  • Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

    Motoharu Awazawa;Kohjiro Ueki;Kazunori Inabe;Toshimasa Yamauchi

  • MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

    Yasuhiko Kawakami;Joaquín Rodríguez-León;Christopher M. Koth;Dirk Büscher

  • Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9

    Masanao Tsuda;Shigeru Takahashi;Yuji Takahashi;Hiroshi Asahara;Hiroshi Asahara

  • Macro view of microRNA function in osteoarthritis

    Shigeru Miyaki;Hiroshi Asahara

  • Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression.

    Keiichiro Nishida;Takamitsu Komiyama;Shin Ichi Miyazawa;Zheng Nan Shen

  • Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system

    Masafumi Inui;Mami Miyado;Maki Igarashi;Moe Tamano

  • Attenuation of a phosphorylation-dependent activator by an HDAC–PP1 complex

    Gianluca Canettieri;Ianessa Morantte;Ernesto Guzmán;Hiroshi Asahara;Hiroshi Asahara

  • FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

    Tokio Matsuzaki;Oscar Alvarez-Garcia;Sho Mokuda;Keita Nagira

  • Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy.

    Shogo Wada;Yoshio Kato;Mitsuharu Okutsu;Mitsuharu Okutsu;Shigeru Miyaki

  • Supplemental Information Adiponectin Enhances Insulin Sensitivity by Increasing Hepatic IRS-2 Expression via a Macrophage-Derived IL-6-Dependent Pathway

    Motoharu Awazawa;Kohjiro Ueki;Kazunori Inabe;Toshimasa Yamauchi

Frequent Co-Authors

Yoshiaki Ito
Yoshiaki Ito National University of Singapore
Martin Lotz
Martin Lotz Scripps Research Institute
Takayuki Sumida
Takayuki Sumida University of Tsukuba
Tetsuji Kobata
Tetsuji Kobata Tokyo Medical and Dental University
Masaki Mori
Masaki Mori Kyushu University
Kusuki Nishioka
Kusuki Nishioka St. Marianna University School of Medicine
Marc Montminy
Marc Montminy Salk Institute for Biological Studies
Satoru Takahashi
Satoru Takahashi University of Tsukuba
Mitsuo Ochi
Mitsuo Ochi Hiroshima University
Tomohiro Kato
Tomohiro Kato St. Marianna University School of Medicine

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