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Overview

Martin Lotz is affiliated with the Scripps Research Institute in the United States, with a research focus primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Rheumatology, Molecular Biology, Cancer Research, Surgery, and Immunology.

Lotz's research has involved extensive investigation into osteoarthritis and related mechanisms, with a particular interest in molecular and cellular pathways influencing cartilage health and joint function. Among the main topics addressed in their publications are:

  • Osteoarthritis Treatment and Mechanisms
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Knee injuries and reconstruction techniques
  • Inflammatory mediators and NSAID effects
  • Cytokine Signaling Pathways and Interactions
  • Circular RNAs in diseases

Their frequent co-authors reflect collaborative work in these areas and include Merissa Olmer, Hannah Swahn, Steven R. Head, Ichiro Kurakazu, and Miguel Otero. Publication venues commonly featuring Lotz's work underscore a focus on rheumatology and cellular biology, with notable journals such as:

  • Osteoarthritis and Cartilage
  • Annals of the Rheumatic Diseases
  • Scientific Reports
  • Frontiers in Cell and Developmental Biology
  • Arthritis & Rheumatology

Recent and influential papers highlight various aspects of cartilage biology and osteoarthritis. These include:

  • "Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis" (2022, Aging Cell)
  • "Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis" (2021, Nature Communications)
  • "FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis" (2020, Proceedings of the National Academy of Sciences)
  • "Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus" (2022, Annals of the Rheumatic Diseases)
  • "Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis" (2020, Scientific Reports)

Best Publications

  • Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

    Yukio Sato;Mark Roman;Helen Tighe;Delphine Lee

  • Effect of neuropeptides on production of inflammatory cytokines by human monocytes

    Martin Lotz;John H. Vaughan;Dennis A. Carson

  • Chondrocyte apoptosis induced by nitric oxide.

    F J Blanco;R L Ochs;H Schwarz;M Lotz

  • Cytokines in symptomatic asthma airways.

    David H. Broide;Martin Lotz;Anthony J. Cuomo;David A. Coburn

  • B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

    M Lotz;F Jirik;P Kabouridis;C Tsoukas

  • Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis.

    Sanshiro Hashimoto;Robert L. Ochs;Setsuro Komiya;Martin Lotz

  • Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology

    Xiaofeng Cui;Kurt Breitenkamp;M.G. Finn;Martin Lotz

  • Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage.

    Saifeddin Alsalameh;Rayya Amin;Takefumi Gemba;Martin Lotz

  • MicroRNA-140 plays dual roles in both cartilage development and homeostasis

    Shigeru Miyaki;Tempei Sato;Atsushi Inoue;Shuhei Otsuki

  • Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis.

    Beatriz Caramés;Noboru Taniguchi;Shuhei Otsuki;Francisco J. Blanco

  • Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

    P A Guerne;B L Zuraw;J H Vaughan;D A Carson

  • Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells.

    F R Jirik;T J Podor;T Hirano;T Kishimoto

  • Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

    Martin Lotz;Dennis A. Carson;John H. Vaughan

  • Thermal inkjet printing in tissue engineering and regenerative medicine

    Xiaofeng Cui;Thomas Boland;Darryl D.D'Lima;Martin K. Lotz

  • Interleukin-17-induced Gene Expression in Articular Chondrocytes Is Associated with Activation of Mitogen-activated Protein Kinases and NF-κB

    Tali Shalom-Barak;Jacqueline Quach;Martin Lotz

  • MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

    Shigeru Miyaki;Tomoyuki Nakasa;Shuhei Otsuki;Shawn P. Grogan

  • Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis.

    Sanshiro Hashimoto;Kenji Takahashi;David Amiel;Richard D. Coutts

  • IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

    P A Guerne;D A Carson;M Lotz

  • Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

    Beatriz Caramés;Akihiko Hasegawa;Noboru Taniguchi;Shigeru Miyaki

  • Effects of aging on articular cartilage homeostasis

    Martin Lotz;Richard F. Loeser

Frequent Co-Authors

Darryl D. D'Lima
Darryl D. D'Lima Scripps Health
Hiroshi Asahara
Hiroshi Asahara Tokyo Medical and Dental University
Dennis A. Carson
Dennis A. Carson University of California, San Diego
Robert Terkeltaub
Robert Terkeltaub University of California, San Diego
Francisco J. Blanco
Francisco J. Blanco University of A Coruña
Clifford W. Colwell
Clifford W. Colwell Scripps Health
Bruce L. Zuraw
Bruce L. Zuraw University of California, San Diego
James A. Koziol
James A. Koziol Scripps Research Institute
Andrew I. Su
Andrew I. Su Scripps Research Institute
David Amiel
David Amiel University of California, San Diego

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