His primary scientific interests are in CpG site, CpG Oligodeoxynucleotide, Immune system, Molecular biology and Immunology. His CpG site study incorporates themes from In vitro, Oligonucleotide, DNA, Adjuvant and DNA vaccination. His work deals with themes such as Toll-Like Receptor 9, T cell, B cell, TLR9 and Cytokine secretion, which intersect with CpG Oligodeoxynucleotide.
His work investigates the relationship between Immune system and topics such as Cancer research that intersect with problems in Cancer immunotherapy. Arthur M. Krieg combines subjects such as Cytokine, Interleukin 12, Lytic cycle, Kinase and In vivo with his study of Molecular biology. His Immunology study integrates concerns from other disciplines, such as Cytotoxic T cell, DNA methylation and Virology.
Arthur M. Krieg mainly focuses on CpG site, Immune system, Immunology, CpG Oligodeoxynucleotide and Molecular biology. Arthur M. Krieg has researched CpG site in several fields, including Nucleic acid, Oligonucleotide, DNA, Adjuvant and Innate immune system. His research integrates issues of Cancer research, Cytokine, Antigen and Cell biology in his study of Immune system.
Arthur M. Krieg interconnects TLR9 and Virology in the investigation of issues within Immunology. His study in CpG Oligodeoxynucleotide is interdisciplinary in nature, drawing from both Toll-Like Receptor 9, Immunity, Peripheral blood mononuclear cell, Cytokine secretion and Cytotoxic T cell. His research investigates the link between Molecular biology and topics such as In vivo that cross with problems in In vitro.
Arthur M. Krieg focuses on Immunology, Immune system, CpG site, CpG Oligodeoxynucleotide and Oligonucleotide. His studies deal with areas such as Cancer and Virology as well as Immunology. His Immune system study combines topics in areas such as Adjuvant, Cancer research and In vivo.
In his study, Potency is inextricably linked to Nucleic acid, which falls within the broad field of CpG site. His CpG Oligodeoxynucleotide research also works with subjects such as
Arthur M. Krieg spends much of his time researching Immunology, CpG Oligodeoxynucleotide, Immune system, Innate immune system and Cytokine. His research investigates the connection with Immunology and areas like Virology which intersect with concerns in Bacterial vaccine, Sepsis, Burkholderia pseudomallei, Biodefense and Melioidosis. His CpG Oligodeoxynucleotide research includes themes of Vaccination and CpG site.
His study focuses on the intersection of CpG site and fields such as Receptor with connections in the field of Cell biology, Cytosol and Intracellular parasite. His biological study spans a wide range of topics, including Human leukocyte antigen and In vivo. The concepts of his Innate immune system study are interwoven with issues in Inflammation, TLR9 and Toll-Like Receptor 9.
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CPG MOTIFS IN BACTERIAL DNA TRIGGER DIRECT B-CELL ACTIVATION
Arthur M. Krieg;Ae-Kyung Yi;Sara Matson;Thomas J. Waldschmidt.
CpG Motifs in Bacterial DNA and Their Immune Effects
Arthur M Krieg.
Annual Review of Immunology (2002)
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
Dennis M. Klinman;Ae-Kyung Yi;Serge L. Beaucage;Jacqueline Conover.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg.
Nature Reviews Drug Discovery (2006)
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.
Rose S. Chu;Oleg S. Targoni;Arthur M. Krieg;Paul V. Lehmann.
Journal of Experimental Medicine (1997)
Immunostimulatory nucleic acid molecules
Arthur M. Krieg;Joel N. Kline;Dennis Klinman;Alfred D. Steinberg.
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
Marion Jurk;Florian Heil;Jörg Vollmer;Christian Schetter.
Nature Immunology (2002)
Identification of CpG oligonucleotide sequences with high induction of IFN‐α/β in plasmacytoid dendritic cells
Anne Krug;Simon Rothenfusser;Veit Hornung;Bernd Jahrsdörfer.
European Journal of Immunology (2001)
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.
Z K Ballas;W L Rasmussen;A M Krieg.
Journal of Immunology (1996)
Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12.
Anne Krug;Andreas Towarowski;Stefanie Britsch;Simon Rothenfusser.
European Journal of Immunology (2001)
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