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Yoshinobu Takakura

Yoshinobu Takakura

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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
83
Citations
22552
World Ranking
909
National Ranking
71

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Yoshinobu Takakura is affiliated with Kyoto University in Japan and has an extensive research portfolio primarily focused on biochemistry, genetics, and molecular biology.

Their main research fields include molecular biology, immunology, biomedical engineering, cancer research, and immunology and allergy. Key topics covered in their work are RNA interference and gene delivery, extracellular vesicles in disease, advanced biosensing and bioanalysis techniques, microRNA in disease regulation, DNA and nucleic acid chemistry, nanoplatforms for cancer theranostics, and immunotherapy and immune responses.

Takakura has authored numerous papers, with notable recent publications including:

  • Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles, 2024, Pharmaceutical Research
  • Extracellular vesicle-based therapeutics: Extracellular vesicles as therapeutic targets and agents, 2023, Pharmacology & Therapeutics
  • Strategies for persistent retention of macromolecules and nanoparticles in the blood circulation, 2022, Journal of Controlled Release
  • Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood, 2021, iScience
  • Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice, 2020, Molecular Therapy

They have published frequently in journals such as Biological and Pharmaceutical Bulletin, Journal of Controlled Release, Journal of Pharmaceutical Sciences, Pharmaceutical Research, and Biomaterials.

Takakura collaborates regularly with a number of researchers, including:

  • Yuki Takahashi
  • Makiya Nishikawa
  • Yusuke Kawamoto
  • Kosuke Kusamori
  • Aki Yamamoto

Best Publications

  • Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection.

    Yuki Takahashi;Makiya Nishikawa;Haruka Shinotsuka;Yuriko Matsui

  • The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake.

    Kenji Kawabata;Yoshinobu Takakura;Mitsuru Hashida

  • In vitro cytotoxicity of macromolecules in different cell culture systems

    Suthummar Choksakulnimitr;Sada Masuda;Hideaki Tokuda;Yoshinobu Takakura

  • Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

    Takafumi Imai;Yuki Takahashi;Makiya Nishikawa;Kana Kato

  • Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA.

    Masaki Morishita;Yuki Takahashi;Akihiro Matsumoto;Makiya Nishikawa

  • Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

    Masaki Morishita;Yuki Takahashi;Makiya Nishikawa;Kohei Sano

  • Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution.

    Yoshinobu Takakura;Mitsuru Hashida

  • Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application.

    Takuma Yamashita;Yuki Takahashi;Yoshinobu Takakura

  • Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics.

    Chonlada Charoenviriyakul;Yuki Takahashi;Masaki Morishita;Akihiro Matsumoto

  • Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice

    Yoshinobu Takakura;Akira Takagi;Mitsuru Hashida;Hitoshi Sezaki

  • Cell-specific delivery of genes with glycosylated carriers.

    Mitsuru Hashida;Makiya Nishikawa;Fumiyoshi Yamashita;Yoshinobu Takakura

  • Interaction between DNA–cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

    F Sakurai;T Nishioka;H Saito;T Baba

  • Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice

    Makiya Nishikawa;Yumiko Mizuno;Kohta Mohri;Nao Matsuoka

  • Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis.

    Makiya Nishikawa;Mitsuru Hashida;Yoshinobu Takakura

  • Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics.

    Masaki Morishita;Yuki Takahashi;Makiya Nishikawa;Yoshinobu Takakura

  • Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression

    Fuminori Sakurai;Rui Inoue;Yasunobu Nishino;Ayumu Okuda

  • Asialoglycoprotein Receptor-Mediated Gene Transfer Using Novel Galactosylated Cationic Liposomes

    Shigeru Kawakami;Fumiyoshi Yamashita;Makiya Nishikawa;Yoshinobu Takakura

  • Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine).

    Mitsuru Hashida;Shigeo Takemura;Makiya Nishikawa;Yoshinobu Takakura

  • Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation.

    Takuma Yamashita;Yuki Takahashi;Makiya Nishikawa;Yoshinobu Takakura

  • Preservation of exosomes at room temperature using lyophilization.

    Chonlada Charoenviriyakul;Yuki Takahashi;Makiya Nishikawa;Yoshinobu Takakura

Frequent Co-Authors

Makiya Nishikawa
Makiya Nishikawa Tokyo University of Science
Mitsuru Hashida
Mitsuru Hashida Kyoto University
Hitoshi Sezaki
Hitoshi Sezaki Kyoto University
Fumiyoshi Yamashita
Fumiyoshi Yamashita Kyoto University
Ram I. Mahato
Ram I. Mahato University of Nebraska Medical Center
Takuya Fujita
Takuya Fujita Ritsumeikan University
Hiroshi Sugiyama
Hiroshi Sugiyama Kyoto University
Masayuki Endo
Masayuki Endo Kyoto University
Ronald T. Borchardt
Ronald T. Borchardt University of Kansas
Kazuo Sakurai
Kazuo Sakurai The University of Kitakyushu

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