D-Index & Metrics Best Publications
Hideyoshi Harashima

Hideyoshi Harashima

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 64 Citations 15,539 329 World Ranking 1961 National Ranking 101

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His main research concerns Liposome, Cell biology, Gene delivery, Biochemistry and Molecular biology. Hideyoshi Harashima has included themes like Lipid bilayer fusion, Cationic liposome, Drug delivery, Endocytosis and In vivo in his Liposome study. His Cell biology research is multidisciplinary, incorporating elements of Viral envelope and Drug carrier.

His Gene delivery study combines topics in areas such as Nanotechnology and Gene expression. The Biochemistry study combines topics in areas such as Biophysics and Aptamer. His Molecular biology research is multidisciplinary, relying on both Systemic administration, Small interfering RNA, DNA, Viral vector and Gene silencing.

His most cited work include:

  • Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery (1006 citations)
  • A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. (451 citations)
  • Stearylated arginine-rich peptides: a new class of transfection systems. (386 citations)

What are the main themes of his work throughout his whole career to date?

Hideyoshi Harashima spends much of his time researching Liposome, Molecular biology, Biochemistry, Cell biology and Transfection. His research in Liposome intersects with topics in Biophysics, Drug delivery, Drug carrier, Pharmacology and In vivo. His Molecular biology study integrates concerns from other disciplines, such as Plasmid, Gene expression, Transgene, DNA and Gene.

Hideyoshi Harashima has researched Cell biology in several fields, including Gene silencing and Endocytosis. His Transfection research includes elements of Transcription, Lipofectamine and Genetic transfer. The concepts of his Gene delivery study are interwoven with issues in Nanotechnology and Nano devices.

He most often published in these fields:

  • Liposome (29.48%)
  • Molecular biology (29.15%)
  • Biochemistry (26.71%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (21.34%)
  • Liposome (29.48%)
  • Drug delivery (10.59%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cell biology, Liposome, Drug delivery, Cancer research and Mitochondrion. His Cell biology research includes themes of Lipid bilayer fusion, Transgene, Immune system and Transfection, Gene delivery. In his research, Gene and Plasmid is intimately related to Molecular biology, which falls under the overarching field of Transgene.

Hideyoshi Harashima focuses mostly in the field of Transfection, narrowing it down to matters related to Gene expression and, in some cases, Luciferase. He interconnects Biophysics, Intracellular and Nanomedicine in the investigation of issues within Drug delivery. His Mitochondrion study introduces a deeper knowledge of Biochemistry.

Between 2016 and 2021, his most popular works were:

  • Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems. (64 citations)
  • Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo (43 citations)
  • Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10 nm for Drug Delivery. (32 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Gene silencing, Drug delivery, Biophysics, Cell biology and Cancer research are his primary areas of study. His research investigates the link between Drug delivery and topics such as Nanomedicine that cross with problems in Microfluidics. His work deals with themes such as Nucleic acid, Peptide, Intracellular, Cationic polymerization and Gene delivery, which intersect with Biophysics.

In his research on the topic of Peptide, Transfection is strongly related with Polyethylene glycol. His Cell biology study incorporates themes from Cell, Transgene, Cellular immunity, Genetic enhancement and Cytotoxic T cell. His Liposome study contributes to a more complete understanding of Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery

Ikramy A. Khalil;Kentaro Kogure;Hidetaka Akita;Hideyoshi Harashima.
Pharmacological Reviews (2006)

1375 Citations

Stearylated arginine-rich peptides: a new class of transfection systems.

Shiroh Futaki;Wakana Ohashi;Tomoki Suzuki;Miki Niwa.
Bioconjugate Chemistry (2001)

601 Citations

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.

Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima.
Advanced Drug Delivery Reviews (2011)

565 Citations

Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.

Ayman El-Sayed;Shiroh Futaki;Hideyoshi Harashima.
Aaps Journal (2009)

490 Citations

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.

H Hatakeyama;H Akita;K Kogure;M Oishi.
Gene Therapy (2007)

437 Citations

High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

Ikramy A. Khalil;Kentaro Kogure;Shiroh Futaki;Hideyoshi Harashima.
Journal of Biological Chemistry (2006)

401 Citations

Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.

Tomoyuki Kakudo;Shinji Chaki;Shiroh Futaki;Ikuhiko Nakase.
Biochemistry (2004)

357 Citations

Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.

Kentaro Kogure;Rumiko Moriguchi;Kentaro Sasaki;Masaharu Ueno.
Journal of Controlled Release (2004)

352 Citations

Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

Ikuhiko Nakase;Hidetaka Akita;Kentaro Kogure;Astrid Gräslund.
Accounts of Chemical Research (2012)

340 Citations

The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

Seiichi Sato;Kai Li;Takeshi Kameyama;Takaya Hayashi.
Immunity (2015)

312 Citations

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