His main research concerns Liposome, Cell biology, Gene delivery, Biochemistry and Molecular biology. Hideyoshi Harashima has included themes like Lipid bilayer fusion, Cationic liposome, Drug delivery, Endocytosis and In vivo in his Liposome study. His Cell biology research is multidisciplinary, incorporating elements of Viral envelope and Drug carrier.
His Gene delivery study combines topics in areas such as Nanotechnology and Gene expression. The Biochemistry study combines topics in areas such as Biophysics and Aptamer. His Molecular biology research is multidisciplinary, relying on both Systemic administration, Small interfering RNA, DNA, Viral vector and Gene silencing.
Hideyoshi Harashima spends much of his time researching Liposome, Molecular biology, Biochemistry, Cell biology and Transfection. His research in Liposome intersects with topics in Biophysics, Drug delivery, Drug carrier, Pharmacology and In vivo. His Molecular biology study integrates concerns from other disciplines, such as Plasmid, Gene expression, Transgene, DNA and Gene.
Hideyoshi Harashima has researched Cell biology in several fields, including Gene silencing and Endocytosis. His Transfection research includes elements of Transcription, Lipofectamine and Genetic transfer. The concepts of his Gene delivery study are interwoven with issues in Nanotechnology and Nano devices.
His scientific interests lie mostly in Cell biology, Liposome, Drug delivery, Cancer research and Mitochondrion. His Cell biology research includes themes of Lipid bilayer fusion, Transgene, Immune system and Transfection, Gene delivery. In his research, Gene and Plasmid is intimately related to Molecular biology, which falls under the overarching field of Transgene.
Hideyoshi Harashima focuses mostly in the field of Transfection, narrowing it down to matters related to Gene expression and, in some cases, Luciferase. He interconnects Biophysics, Intracellular and Nanomedicine in the investigation of issues within Drug delivery. His Mitochondrion study introduces a deeper knowledge of Biochemistry.
Gene silencing, Drug delivery, Biophysics, Cell biology and Cancer research are his primary areas of study. His research investigates the link between Drug delivery and topics such as Nanomedicine that cross with problems in Microfluidics. His work deals with themes such as Nucleic acid, Peptide, Intracellular, Cationic polymerization and Gene delivery, which intersect with Biophysics.
In his research on the topic of Peptide, Transfection is strongly related with Polyethylene glycol. His Cell biology study incorporates themes from Cell, Transgene, Cellular immunity, Genetic enhancement and Cytotoxic T cell. His Liposome study contributes to a more complete understanding of Biochemistry.
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Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
Ikramy A. Khalil;Kentaro Kogure;Hidetaka Akita;Hideyoshi Harashima.
Pharmacological Reviews (2006)
Stearylated arginine-rich peptides: a new class of transfection systems.
Shiroh Futaki;Wakana Ohashi;Tomoki Suzuki;Miki Niwa.
Bioconjugate Chemistry (2001)
A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.
Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima.
Advanced Drug Delivery Reviews (2011)
Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.
Ayman El-Sayed;Shiroh Futaki;Hideyoshi Harashima.
Aaps Journal (2009)
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.
H Hatakeyama;H Akita;K Kogure;M Oishi.
Gene Therapy (2007)
High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression
Ikramy A. Khalil;Kentaro Kogure;Shiroh Futaki;Hideyoshi Harashima.
Journal of Biological Chemistry (2006)
Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.
Tomoyuki Kakudo;Shinji Chaki;Shiroh Futaki;Ikuhiko Nakase.
Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.
Kentaro Kogure;Rumiko Moriguchi;Kentaro Sasaki;Masaharu Ueno.
Journal of Controlled Release (2004)
Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides
Ikuhiko Nakase;Hidetaka Akita;Kentaro Kogure;Astrid Gräslund.
Accounts of Chemical Research (2012)
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
Seiichi Sato;Kai Li;Takeshi Kameyama;Takaya Hayashi.
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