World's Best Scientists 2026 revealed!
Hideyoshi Harashima

Hideyoshi Harashima

D-Index & Metrics

Molecular Biology

D-Index
97
Citations
33923
World Ranking
592
National Ranking
45

Overview

Hideyoshi Harashima is affiliated with Hokkaido University in Japan and has a research portfolio characterized by extensive contributions to the fields of biochemistry, genetics, molecular biology, and medicine. Their work primarily intersects molecular biology and immunology, with additional focus on biomedical engineering, oncology, and genetics.

The scientist has authored numerous publications, including influential papers such as "Clinical translation of nanomedicines: Challenges, opportunities, and keys" (2021, Advanced Drug Delivery Reviews), "STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation" (2021, Journal for ImmunoTherapy of Cancer), "The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution" (2020, Molecular Pharmaceutics), "Power of mitochondrial drug delivery systems to produce innovative nanomedicines" (2020, Advanced Drug Delivery Reviews), and "Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines" (2022, Advanced Drug Delivery Reviews).

These works reflect key research areas including RNA interference and gene delivery, immunotherapy and immune responses, immune cell function and interaction, mitochondrial function and pathology, advanced biosensing and bioanalysis techniques, nanoplatforms for cancer theranostics, and virus-based gene therapy research.

Frequent collaborators include Yusuke Sato, Yuma Yamada, Takashi Nakamura, Masatoshi Maeki, and Manabu Tokeshi, denoting a pattern of cooperative research output with established peers in related disciplines.

The scientist regularly publishes in several notable academic journals, with predominant appearances in the Journal of Controlled Release, Pharmaceutics, Molecular Pharmaceutics, International Journal of Molecular Sciences, and Advanced Drug Delivery Reviews.

  • Clinical translation of nanomedicines: Challenges, opportunities, and keys (2021, Advanced Drug Delivery Reviews)
  • STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation (2021, Journal for ImmunoTherapy of Cancer)
  • The Effect of Size and Charge of Lipid Nanoparticles Prepared by Microfluidic Mixing on Their Lymph Node Transitivity and Distribution (2020, Molecular Pharmaceutics)
  • Power of mitochondrial drug delivery systems to produce innovative nanomedicines (2020, Advanced Drug Delivery Reviews)
  • Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines (2022, Advanced Drug Delivery Reviews)

  • Yusuke Sato
  • Yuma Yamada
  • Takashi Nakamura
  • Masatoshi Maeki
  • Manabu Tokeshi

  • Journal of Controlled Release
  • Pharmaceutics
  • Molecular Pharmaceutics
  • International Journal of Molecular Sciences
  • Advanced Drug Delivery Reviews

  • RNA Interference and Gene Delivery
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • Mitochondrial Function and Pathology
  • Advanced biosensing and bioanalysis techniques
  • Nanoplatforms for cancer theranostics
  • Virus-based gene therapy research

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

  • Molecular Biology
  • Immunology
  • Biomedical Engineering
  • Oncology
  • Genetics

Best Publications

  • Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery

    Ikramy A. Khalil;Kentaro Kogure;Hidetaka Akita;Hideyoshi Harashima

  • A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.

    Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima

  • Stearylated arginine-rich peptides: a new class of transfection systems.

    Shiroh Futaki;Wakana Ohashi;Tomoki Suzuki;Miki Niwa

  • Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment.

    Ayman El-Sayed;Shiroh Futaki;Hideyoshi Harashima

  • Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.

    H Hatakeyama;H Akita;K Kogure;M Oishi

  • The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.

    Hiroto Hatakeyama;Hidetaka Akita;Hideyoshi Harashima

  • The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus

    Seiichi Sato;Kai Li;Takeshi Kameyama;Takaya Hayashi

  • High Density of Octaarginine Stimulates Macropinocytosis Leading to Efficient Intracellular Trafficking for Gene Expression

    Ikramy A. Khalil;Kentaro Kogure;Shiroh Futaki;Hideyoshi Harashima

  • Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

    Ikuhiko Nakase;Hidetaka Akita;Kentaro Kogure;Astrid Gräslund

  • Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system.

    Tomoyuki Kakudo;Shinji Chaki;Shiroh Futaki;Ikuhiko Nakase

  • MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

    Yuma Yamada;Hidetaka Akita;Hiroyuki Kamiya;Kentaro Kogure

  • Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method.

    Kentaro Kogure;Rumiko Moriguchi;Kentaro Sasaki;Masaharu Ueno

  • Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.

    Ayman El-Sayed;Hideyoshi Harashima

  • A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

    Yusuke Sato;Hiroto Hatakeyama;Yu Sakurai;Mamoru Hyodo

  • Mitochondrial drug delivery systems for macromolecule and their therapeutic application to mitochondrial diseases.

    Yuma Yamada;Hideyoshi Harashima

  • Quantitative Comparison of Intracellular Trafficking and Nuclear Transcription between Adenoviral and Lipoplex Systems

    Susumu Hama;Hidetaka Akita;Rie Ito;Hiroyuki Mizuguchi

  • Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery

    Tooru Ooya;Hak Soo Choi;Atsushi Yamashita;Nobuhiko Yui

  • Octaarginine-modified multifunctional envelope-type nano device for siRNA

    Yoshio Nakamura;Kentaro Kogure;Shiroh Futaki;Hideyoshi Harashima

  • Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems.

    Masatoshi Maeki;Niko Kimura;Yusuke Sato;Hideyoshi Harashima

  • A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo.

    Hiroto Hatakeyama;Erika Ito;Hidetaka Akita;Motoi Oishi

Frequent Co-Authors

Hidetaka Akita
Hidetaka Akita Chiba University
Hiroyuki Kamiya
Hiroyuki Kamiya Hiroshima University
Kentaro Kogure
Kentaro Kogure University of Tokushima
Shiroh Futaki
Shiroh Futaki Kyoto University
Yoshinobu Baba
Yoshinobu Baba Nagoya University
Manabu Tokeshi
Manabu Tokeshi Hokkaido University
Nobuhiko Yui
Nobuhiko Yui Tokyo Medical and Dental University
Yasuo Shinohara
Yasuo Shinohara University of Tokushima
Tooru Ooya
Tooru Ooya Kobe University
Hiroshi Kasai
Hiroshi Kasai University of Occupational and Environmental Health Japan

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring molecular biology in the USA can open doors to various related fields available through flexible online study. Students interested in helping others might consider expanding into behavioral or mental health with an accelerated master's in psychology, ideal for those seeking to advance quickly while balancing other commitments.

For those focused on social impact, social work masters programs online provide rigorous training in human behavior, policy, and counseling. These programs can be especially beneficial for students with a science background who wish to work directly with communities.

Military-affiliated learners may benefit from military friendly online schools that offer degree pathways with extra support and flexibility for veterans and active-duty students.

Finally, students drawn to supporting mental well-being could explore an online masters degree in mental health counseling. These options equip graduates with the tools needed to pursue careers at the intersection of science and care.

Best Scientists Citing Hideyoshi Harashima

Trending Scientists