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Biology and Biochemistry
USA
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
158
Citations
82380
World Ranking
135
National Ranking
99

Medicine

D-Index
158
Citations
81623
World Ranking
866
National Ranking
494

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2003 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Leaf Huang is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and medicine. The scientist has contributed extensively to molecular biology, immunology, oncology, biomaterials, and biomedical engineering.

Their work addresses topics including RNA interference and gene delivery, nanoparticle-based drug delivery, immunotherapy and immune responses, nanoplatforms for cancer theranostics, advanced biosensing and bioanalysis techniques, cancer immunotherapy and biomarkers, and monoclonal and polyclonal antibodies research.

Among recent publications by Leaf Huang are:

  • mRNA vaccine for cancer immunotherapy, 2021, Molecular Cancer
  • Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma, 2020, ACS Nano
  • Nano Codelivery of Oxaliplatin and Folinic Acid Achieves Synergistic Chemo-Immunotherapy with 5-Fluorouracil for Colorectal Cancer and Liver Metastasis, 2020, ACS Nano
  • Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model, 2020, Biomaterials
  • Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses, 2023, Nature Biotechnology

Leaf Huang has collaborated frequently with several co-authors across numerous projects. Notable collaborators include Mengying Hu, Yun Liu, Rihe Liu, Yuhua Wang, and Wantong Song.

The scientist's work has been published in venues such as UNC Libraries, OPAL (Open@LaTrobe) from La Trobe University, Biomaterials, Journal of Controlled Release, and Frontiers in Nutrition.

Leaf Huang has been recognized by being named a Fellow of the Indian National Academy of Engineering (INAE) in 2003.

Best Publications

  • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

    Alexander L. Klibanov;Kazuo Maruyama;Vladimir P. Torchilin;Leaf Huang

  • Pharmacokinetics and biodistribution of nanoparticles.

    Shyh Dar Li;Leaf Huang

  • A novel cationic liposome reagent for efficient transfection of mammalian cells

    Xiang Gao;Leaf Huang

  • Gene therapy progress and prospects: nonviral vectors.

    T Niidome;L Huang

  • Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans

    Gary J. Nabel;Elizabeth G. Nabel;Zhi Yong Yang;Bernard A. Fox

  • THE ROLE OF DIOLEOYL PHOSPHATIDYLETHANOLAMINE IN CATIONIC LIPOSOME MEDIATED GENE TRANSFER

    Hassan Farhood;Natalya Serbina;Leaf Huang

  • Cationic liposome-mediated gene transfer.

    X Gao;L Huang

  • Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.

    Natasha J. Caplen;Eric W.F.W. Alton;Peter G. Mddleton;Julia R. Dorin

  • Nonviral gene therapy: promises and challenges.

    S Li;L Huang

  • Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer

    Makiya Nishikawa;Leaf Huang

  • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo.

    Jennifer Rubin Grandis;Stephanie D. Drenning;Qing Zeng;Simon C. Watkins

  • DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action.

    Xiaohuai Zhou;Leaf Huang

  • Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target.

    Aleksander L. Klibanov;Kazuo Maruyama;Anne Marie Beckerleg;Vladimir P. Torchilin

  • Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes.

    David C. Litzinger;Antoinette M.J. Buiting;Nico van Rooijen;Leaf Huang

  • In vivo delivery of miRNAs for cancer therapy: challenges and strategies.

    Yunching Chen;Dong Yu Gao;Leaf Huang

  • Recent advances in nonviral vectors for gene delivery

    Xia Guo;Leaf Huang

  • Potentiation of cationic liposome-mediated gene delivery by polycations

    Xiang Gao;Leaf Huang

  • In vivo gene transfer via intravenous administration of cationic lipid–protamine–DNA (LPD) complexes

    S Li;L Huang

  • mRNA vaccine for cancer immunotherapy.

    Lei Miao;Yu Zhang;Leaf Huang

  • Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.

    Yunching Chen;Xiaodong Zhu;Xiaoju Zhang;Bin Liu

Frequent Co-Authors

Song Li
Song Li University of Pittsburgh
Stephen J. Kennel
Stephen J. Kennel University of Tennessee Medical Center
Naoki Yoshimura
Naoki Yoshimura University of Pittsburgh
Michael B. Chancellor
Michael B. Chancellor University of Pittsburgh
Barry T. Rouse
Barry T. Rouse University of Tennessee at Knoxville
Duncan M. Geddes
Duncan M. Geddes Imperial College London
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Richard M. Epand
Richard M. Epand McMaster University
Vladimir P. Torchilin
Vladimir P. Torchilin Northeastern University
Natasha J. Caplen
Natasha J. Caplen National Institutes of Health

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