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Biology and Biochemistry
Canada
2025

D-Index & Metrics

Biology and Biochemistry

D-Index
118
Citations
64273
World Ranking
692
National Ranking
15

Research.com Recognitions

  • 2025 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Pieter R. Cullis is affiliated with the University of British Columbia in Canada and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology, biomedical engineering, immunology, pulmonary and respiratory medicine, and hematology.

The main topics of study in Pieter R. Cullis's work include:

  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Lipid Membrane Structure and Behavior
  • Nanoparticle-Based Drug Delivery
  • Platelet Disorders and Treatments
  • Virus-based gene therapy research
  • Animal Virus Infections Studies

Frequent co-authors collaborating with Pieter R. Cullis include:

  • Jayesh A. Kulkarni
  • Dominik Witzigmann
  • Jerry Leung
  • Miffy H. Y. Cheng
  • Yao Zhang

Pieter R. Cullis's research has been published in several scientific venues with noteworthy frequency. These include:

  • ACS Nano
  • Molecular Therapy - Methods & Clinical Development
  • Langmuir
  • Journal of Controlled Release
  • Blood

Recent papers by Pieter R. Cullis or their close collaborators cover a range of topics in nanotechnology, lipid nanoparticles, and gene therapy:

  • "The current landscape of nucleic acid therapeutics," 2021, Nature Nanotechnology
  • "Lipid nanoparticle technology for therapeutic gene regulation in the liver," 2020, Advanced Drug Delivery Reviews
  • "The 60-year evolution of lipid nanoparticles for nucleic acid delivery," 2024, Nature Reviews Drug Discovery
  • "The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy," 2020, Bioconjugate Chemistry
  • "Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency," 2023, Advanced Materials

Best Publications

  • Drug Delivery Systems: Entering the Mainstream

    Theresa M. Allen;Pieter R. Cullis

  • Liposomal drug delivery systems: from concept to clinical applications.

    Theresa M. Allen;Pieter R. Cullis

  • Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

    M.J. Hope;M.B. Bally;G. Webb;P.R. Cullis

  • Lipid polymorphism and the functional roles of lipids in biological membranes.

    P.R. Cullis;B. De Kruijff

  • Vesicles of variable sizes produced by a rapid extrusion procedure

    L.D. Mayer;M.J. Hope;P.R. Cullis

  • Rational design of cationic lipids for siRNA delivery

    Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu

  • The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    Akin Akinc;Martin A. Maier;Muthiah Manoharan;Kevin Fitzgerald

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

    Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam

  • The current landscape of nucleic acid therapeutics.

    Jayesh A. Kulkarni;Dominik Witzigmann;Sarah B. Thomson;Sam Chen

  • Lipid Nanoparticle Systems for Enabling Gene Therapies.

    Pieter R. Cullis;Michael J. Hope

  • Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

    Nathan M Belliveau;Jens Huft;Paulo Jc Lin;Sam Chen

  • Liposomal compositions for enhanced retention of bioactive agents

    Marcel B. Bally;Nancy L. Boman;Pieter R. Cullis;Lawrence D. Mayer

  • On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids.

    IM Hafez;N Maurer;PR Cullis

  • Nomenclature for Synthetic Gene Delivery Systems

    P. L. Felgner;Y. Barenholz;J. P. Behr;S. H. Cheng

  • Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles.

    L.D. Mayer;M.J. Hope;P.R. Cullis;A.S. Janoff

  • Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

    A Chonn;S.C. Semple;P.R. Cullis

  • Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures.

    S. C. Semple;S. K. Klimuk;T. O. Harasym;N. Dos Santos

  • Generation of multilamellar and unilamellar phospholipid vesicles

    M.J. Hope;M.B. Bally;L.D. Mayer;A.S. Janoff

  • The polymorphic phase behaviour of phosphatidylethanolamines of natural and synthetic origin. A 31P NMR study.

    P.R Cullis;B De Kruijff

  • The liposomal formulation of doxorubicin.

    Sheela A Abraham;Dawn N Waterhouse;Lawrence D Mayer;Pieter R Cullis

Frequent Co-Authors

Michael J. Hope
Michael J. Hope University of British Columbia
Marcel B. Bally
Marcel B. Bally University of British Columbia
Lawrence D. Mayer
Lawrence D. Mayer University of British Columbia
Andrew S. Janoff
Andrew S. Janoff Princeton University
Marco A. Ciufolini
Marco A. Ciufolini University of British Columbia
B. de Kruijff
B. de Kruijff Utrecht University
Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)
Arie J. Verkleij
Arie J. Verkleij Utrecht University
Sol M. Gruner
Sol M. Gruner Cornell University
Kallanthottathil G. Rajeev
Kallanthottathil G. Rajeev Alnylam Pharmaceuticals (United States)

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