World's Best Scientists 2026 revealed!

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Chemistry

D-Index
103
Citations
49794
World Ranking
1093
National Ranking
437

Biology and Biochemistry

D-Index
107
Citations
59581
World Ranking
1078
National Ranking
647

Overview

Muthiah Manoharan is affiliated with Alnylam Pharmaceuticals in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Molecular Biology. Their scholarly work spans multiple subfields including Materials Chemistry, Cancer Research, Organic Chemistry, and Infectious Diseases.

The scientist's main research topics include RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, DNA and Nucleic Acid Chemistry, RNA and protein synthesis mechanisms, RNA modifications and cancer, Crystallization and Solubility Studies, and X-ray Diffraction in Crystallography.

Frequent coauthors of Muthiah Manoharan include:

  • Martin Egli
  • Mark K. Schlegel
  • Joel M. Harp
  • Shigeo Matsuda
  • Dhrubajyoti Datta

Their publications appear most often in the following venues:

  • Nucleic Acids Research
  • The Cambridge Structural Database
  • Organic Letters
  • Journal of the American Chemical Society
  • Chemical Communications

Selected recent papers authored or coauthored by Muthiah Manoharan include:

  • Chemistry, structure and function of approved oligonucleotide therapeutics, 2023, Nucleic Acids Research
  • Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates, 2020, Nucleic Acids Research
  • Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates, 2022, Nature Biotechnology
  • The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human, 2021, Drug Metabolism and Disposition
  • From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization, 2022, Nucleic Acids Research

Best Publications

  • Silencing of microRNAs in vivo with ‘antagomirs’

    Jan Krützfeldt;Nikolaus Rajewsky;Ravi Braich;Kallanthottathil G. Rajeev

  • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    Jürgen Soutschek;Akin Akinc;Birgit Bramlage;Klaus Charisse

  • Rational design of cationic lipids for siRNA delivery

    Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu

  • RNAi-mediated gene silencing in non-human primates

    Tracy S. Zimmermann;Amy C. H. Lee;Akin Akinc;Birgit Bramlage

  • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

    Veit Hornung;Margit Guenthner-Biller;Carole Bourquin;Andrea Ablasser

  • The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    Akin Akinc;Martin A. Maier;Muthiah Manoharan;Kevin Fitzgerald

  • miR-181a is an intrinsic modulator of T cell sensitivity and selection

    Qi Jing Li;Jacqueline Chau;Peter J.R. Ebert;Giselle Sylvester

  • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    Akin Akinc;Andreas Zumbuehl;Andreas Zumbuehl;Michael Goldberg;Elizaveta S Leshchiner

  • RNAi therapeutics: a potential new class of pharmaceutical drugs.

    David Bumcrot;Muthiah Manoharan;Victor Koteliansky;Dinah W Y Sah

  • Oligonucleotides containing N-2 substituted purines

    Phillip D. Cook;Kanda S. Ramasamy;Muthiah Manoharan

  • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    Hyukjin Lee;Abigail K. R. Lytton-Jean;Yi Chen;Kevin T. Love

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

    Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam

  • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

    Akin Akinc;William Querbes;Soma De;June Qin

  • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

    Christian Wolfrum;Shuanping Shi;K Narayanannair Jayaprakash;Muthusamy Jayaraman

  • Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    Jayaprakash K. Nair;Jennifer L. S. Willoughby;Amy Chan;Klaus Charisse

  • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie

  • Chemistry, structure and function of approved oligonucleotide therapeutics

    Unknown

  • A viral microRNA functions as an orthologue of cellular miR-155

    Eva Gottwein;Neelanjan Mukherjee;Christoph Sachse;Corina Frenzel

  • Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

    Anders Wittrup;Angela Ai;Xing Liu;Peter Hamar

  • Substituted purines and oligonucleotide cross-linking

    Phillip Dan Cook;Muthiah Manoharan;Kanda S. Ramasamy

  • Specificity, duplex degradation and subcellular localization of antagomirs

    Jan Krützfeldt;Satoru Kuwajima;Ravi Braich;Kallanthottathil G. Rajeev

  • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    Alfica Sehgal;William Querbes;Christopher S. Zurenko;Muthusamy Jayaraman

Frequent Co-Authors

Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)
Martin Egli
Martin Egli Vanderbilt University
Martin E. Maier
Martin E. Maier University of Tübingen
Phillip Dan Cook
Phillip Dan Cook Ionis Pharmaceuticals (United States)
Michael E. Jung
Michael E. Jung University of California, Los Angeles
Markus Stoffel
Markus Stoffel University of Geneva
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Victor Koteliansky
Victor Koteliansky Skolkovo Institute of Science and Technology
Antonin de Fougerolles
Antonin de Fougerolles Alnylam Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)

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