World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
59581
World Ranking
1078
National Ranking
647

Chemistry

D-Index
103
Citations
49794
World Ranking
1093
National Ranking
436

Muthiah Manoharan publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Muthiah Manoharan sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 432 publications — 92nd percentile

92% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Muthiah Manoharan D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Muthiah Manoharan sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 107 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Muthiah Manoharan is affiliated with Alnylam Pharmaceuticals in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Molecular Biology. Their scholarly work spans multiple subfields including Materials Chemistry, Cancer Research, Organic Chemistry, and Infectious Diseases.

The scientist's main research topics include RNA Interference and Gene Delivery, Advanced biosensing and bioanalysis techniques, DNA and Nucleic Acid Chemistry, RNA and protein synthesis mechanisms, RNA modifications and cancer, Crystallization and Solubility Studies, and X-ray Diffraction in Crystallography.

Frequent coauthors of Muthiah Manoharan include:

  • Martin Egli
  • Mark K. Schlegel
  • Joel M. Harp
  • Shigeo Matsuda
  • Dhrubajyoti Datta

Their publications appear most often in the following venues:

  • Nucleic Acids Research
  • The Cambridge Structural Database
  • Organic Letters
  • Journal of the American Chemical Society
  • Chemical Communications

Selected recent papers authored or coauthored by Muthiah Manoharan include:

  • Chemistry, structure and function of approved oligonucleotide therapeutics, 2023, Nucleic Acids Research
  • Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates, 2020, Nucleic Acids Research
  • Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates, 2022, Nature Biotechnology
  • The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human, 2021, Drug Metabolism and Disposition
  • From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization, 2022, Nucleic Acids Research

Best Publications

  • Silencing of microRNAs in vivo with ‘antagomirs’

    Jan Krützfeldt;Nikolaus Rajewsky;Ravi Braich;Kallanthottathil G. Rajeev

  • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

    Jürgen Soutschek;Akin Akinc;Birgit Bramlage;Klaus Charisse

  • Rational design of cationic lipids for siRNA delivery

    Sean C Semple;Akin Akinc;Jianxin Chen;Ammen P Sandhu

  • RNAi-mediated gene silencing in non-human primates

    Tracy S. Zimmermann;Amy C. H. Lee;Akin Akinc;Birgit Bramlage

  • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.

    Veit Hornung;Margit Guenthner-Biller;Carole Bourquin;Andrea Ablasser

  • The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

    Akin Akinc;Martin A. Maier;Muthiah Manoharan;Kevin Fitzgerald

  • miR-181a is an intrinsic modulator of T cell sensitivity and selection

    Qi Jing Li;Jacqueline Chau;Peter J.R. Ebert;Giselle Sylvester

  • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    Akin Akinc;Andreas Zumbuehl;Andreas Zumbuehl;Michael Goldberg;Elizaveta S Leshchiner

  • RNAi therapeutics: a potential new class of pharmaceutical drugs.

    David Bumcrot;Muthiah Manoharan;Victor Koteliansky;Dinah W Y Sah

  • Oligonucleotides containing N-2 substituted purines

    Phillip D. Cook;Kanda S. Ramasamy;Muthiah Manoharan

  • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    Hyukjin Lee;Abigail K. R. Lytton-Jean;Yi Chen;Kevin T. Love

  • Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

    Muthusamy Jayaraman;Steven M. Ansell;Barbara L. Mui;Ying K. Tam

  • Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

    Akin Akinc;William Querbes;Soma De;June Qin

  • Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

    Christian Wolfrum;Shuanping Shi;K Narayanannair Jayaprakash;Muthusamy Jayaraman

  • Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

    Jayaprakash K. Nair;Jennifer L. S. Willoughby;Amy Chan;Klaus Charisse

  • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Maria Frank-Kamenetsky;Aldo Grefhorst;Norma N. Anderson;Timothy S. Racie

  • Chemistry, structure and function of approved oligonucleotide therapeutics

    Unknown

  • A viral microRNA functions as an orthologue of cellular miR-155

    Eva Gottwein;Neelanjan Mukherjee;Christoph Sachse;Corina Frenzel

  • Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

    Anders Wittrup;Angela Ai;Xing Liu;Peter Hamar

  • Substituted purines and oligonucleotide cross-linking

    Phillip Dan Cook;Muthiah Manoharan;Kanda S. Ramasamy

  • Specificity, duplex degradation and subcellular localization of antagomirs

    Jan Krützfeldt;Satoru Kuwajima;Ravi Braich;Kallanthottathil G. Rajeev

  • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    Alfica Sehgal;William Querbes;Christopher S. Zurenko;Muthusamy Jayaraman

Frequent Co-Authors

Martin Maier
Martin Maier Alnylam Pharmaceuticals (United States)
Martin Egli
Martin Egli Vanderbilt University
Martin E. Maier
Martin E. Maier University of Tübingen
Phillip Dan Cook
Phillip Dan Cook Ionis Pharmaceuticals (United States)
Michael E. Jung
Michael E. Jung University of California, Los Angeles
Markus Stoffel
Markus Stoffel University of Geneva
Theo J.C. Van Berkel
Theo J.C. Van Berkel Leiden University
Victor Koteliansky
Victor Koteliansky Skolkovo Institute of Science and Technology
Antonin de Fougerolles
Antonin de Fougerolles Alnylam Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)

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