What is he best known for?
The fields of study he is best known for:
His primary areas of study are Oligonucleotide, Biochemistry, RNA, RNA interference and Gene silencing.
His biological study spans a wide range of topics, including Gene expression, Conjugated system, Stereochemistry, Organic chemistry and Nuclease.
His RNA research is multidisciplinary, relying on both Virus, Influenza A virus, Virology and Polymerase.
His RNA interference research includes elements of Factor IX, Computational biology and Drug.
His research in Gene silencing intersects with topics in Trans-acting siRNA, Small interfering RNA, Molecular biology, microRNA and In vivo.
The Small interfering RNA study combines topics in areas such as Interferon, Cholesterol, Small hairpin RNA and Pharmacology.
His most cited work include:
- Silencing of microRNAs in vivo with ‘antagomirs’ (3416 citations)
- Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs (2009 citations)
- RNAi-mediated gene silencing in non-human primates (1221 citations)
What are the main themes of his work throughout his whole career to date?
Muthiah Manoharan mainly investigates Oligonucleotide, Biochemistry, Stereochemistry, RNA and Combinatorial chemistry.
His research investigates the connection with Oligonucleotide and areas like Reagent which intersect with concerns in Oligonucleotide synthesis.
The various areas that Muthiah Manoharan examines in his RNA study include Molecular biology, Gene silencing and DNA.
His Molecular biology research is multidisciplinary, incorporating elements of RNA silencing and Gene expression.
His work carried out in the field of Gene silencing brings together such families of science as In vivo and Trans-acting siRNA.
His research integrates issues of Cancer research, Pharmacology and Cell biology in his study of RNA interference.
He most often published in these fields:
- Oligonucleotide (48.98%)
- Biochemistry (29.48%)
- Stereochemistry (26.98%)
What were the highlights of his more recent work (between 2011-2021)?
- RNA interference (16.78%)
- RNA (25.40%)
- Small interfering RNA (13.61%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in RNA interference, RNA, Small interfering RNA, Gene silencing and Biochemistry.
His studies deal with areas such as Cancer research, Transthyretin and Pharmacology as well as RNA interference.
His RNA study combines topics from a wide range of disciplines, such as Molecular biology, Oligonucleotide and Nucleotide.
His Oligonucleotide study incorporates themes from Combinatorial chemistry, Bicyclic molecule, Stereochemistry and Nucleic acid.
The Small interfering RNA study which covers Cell biology that intersects with Gene knockdown, Endocytosis and Messenger RNA.
His Gene silencing study combines topics in areas such as RNA-induced silencing complex, Argonaute, Trans-acting siRNA, RNAi Therapeutics and In vivo.
Between 2011 and 2021, his most popular works were:
- Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery (688 citations)
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing (509 citations)
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo (444 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in RNA interference, Small interfering RNA, Gene silencing, In vivo and RNA.
His RNA interference research is multidisciplinary, incorporating perspectives in Duplex, Cancer research, Transthyretin and Immunology.
His Small interfering RNA study integrates concerns from other disciplines, such as Asialoglycoprotein receptor, Oligonucleotide, Gene knockdown and Cell biology.
His biological study deals with issues like Stereochemistry, which deal with fields such as Ligand and N-Acetylgalactosamine.
His studies in Gene silencing integrate themes in fields like Putamen, Pharmacology and Therapeutic index.
The In vivo study combines topics in areas such as Biophysics, Potency, Drug delivery, RNAi Therapeutics and Molecular biology.
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