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Chemistry

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71
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79
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21738
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4327
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Overview

Eric E. Swayze is affiliated with Ionis Pharmaceuticals in the United States. Their research primarily falls within the fields of biochemistry, genetics, and molecular biology, with a total of 43 publications. Additionally, they have contributed to the field of medicine through 19 published works.

Their work focuses on several subfields, including molecular biology, genetics, neurology, cellular and molecular neuroscience, and physiology. The main topics covered by their research include advanced biosensing and bioanalysis techniques, DNA and nucleic acid chemistry, RNA interference and gene delivery, RNA and protein synthesis mechanisms, neurogenetic and muscular disorders research, Parkinson's disease mechanisms and treatments, and RNA research and splicing.

Frequent coauthors in Eric E. Swayze's research include Holly Kordasiewicz, Punit P. Seth, Hien Zhao, Michael T. Migawa, and Paymaan Jafar-Nejad.

Eric E. Swayze has published extensively in several scientific venues. Notable publication venues include:

  • Nucleic Acids Research (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Molecular Therapy - Nucleic Acids (3 publications)
  • Nature Medicine (2 publications)
  • Nucleic Acid Therapeutics (2 publications)

Notable recent papers authored or coauthored by Eric E. Swayze include:

  • Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial, 2023, Nature Medicine
  • α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease, 2021, JCI Insight
  • Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides, 2021, Nucleic Acids Research
  • The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration, 2020, Nucleic Acids Research
  • Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides, 2020, Nucleic Acids Research

Best Publications

  • RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

    C Frank Bennett;Eric E Swayze

  • Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

    Charles R. Allerson;Namir Sioufi;Russell Jarres;Thazha P. Prakash

  • Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

    Thazha P. Prakash;Mark J. Graham;Jinghua Yu;Rick Carty

  • Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

    Eric E. Swayze;Andrew M. Siwkowski;Edward V. Wancewicz;Michael T. Migawa

  • Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.

    Sarah L. DeVos;Rebecca L. Miller;Kathleen M. Schoch;Brandon B. Holmes

  • Positional effect of chemical modifications on short interference RNA activity in mammalian cells.

    Thazha P. Prakash;Charles R. Allerson;Prasad Dande;Timothy A. Vickers

  • Targeting Huntingtin Expression in Patients with Huntington’s Disease

    Sarah J. Tabrizi;Blair R. Leavitt;G. Bernhard Landwehrmeyer;Edward J. Wild

  • Pharmacology of Antisense Drugs

    C. Frank Bennett;Brenda F. Baker;Nguyen Pham;Eric Swayze

  • N-Substituerede bicycliske nukleinsyreanaloge med aminomethylenbro

    Swayze Eric E;Prakash Thazha P;Bhat Balkrishen

  • 6-modified bicyclic nucleic acid analogs

    Eric E. Swayze;Punit P. Seth

  • 5′-modified bicyclic nucleic acid analogs

    Punit P. Seth;Eric E. Swayze

  • Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation

    Charles Allerson;Balkrishen Bhat;Ann B. Eldrup;Muthiah Manoharan

  • Compositions comprising alternating 2'-modified nucleosides for use in gene modulation

    Charles Allerson;Balkrishen Bhat;Anne B. Eldrup;Muthiah Manoharan

  • Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression

    Dongbo Yu;Hannah Pendergraff;Jing Liu;Holly B. Kordasiewicz;Holly B. Kordasiewicz

  • Single-stranded siRNAs activate RNAi in animals

    Walt F. Lima;Thazha P. Prakash;Heather M. Murray;Garth A. Kinberger

  • Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

    Punit P. Seth;Andrew Siwkowski;Charles R. Allerson;Guillermo Vasquez

  • Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

    Alex McCampbell;Tracy Cole;Amy J. Wegener;Giulio S. Tomassy

  • Carbocyclic alpha-l-bicyclic nucleic acid analogs

    Punit P. Seth;Eric E. Swayze

  • Double strand compositions comprising differentially modified strands for use in gene modulation

    Balkrishen Bhat;Thazha P. Prakash;Prasad Dande;Charles Allerson

  • Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

    Punit P. Seth;Guillermo Vasquez;Charles A. Allerson;Andres Berdeja

  • Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation

    Balkrishen Bhat;Prasad Dande;Thazha P. Prakash;Charles Allerson

Frequent Co-Authors

Punit P. Seth
Punit P. Seth Ionis Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
Richard S. Geary
Richard S. Geary Ionis Pharmaceuticals (United States)
Stanley T. Crooke
Stanley T. Crooke Ionis Pharmaceuticals (United States)
Stephen Hanessian
Stephen Hanessian University of Montreal
Leroy B. Townsend
Leroy B. Townsend University of Michigan–Ann Arbor
Brett P. Monia
Brett P. Monia Ionis Pharmaceuticals (United States)
David J. Ecker
David J. Ecker Ionis Pharmaceuticals (United States)
Yun He
Yun He Chongqing University
David R. Corey
David R. Corey The University of Texas Southwestern Medical Center

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