His primary scientific interests are in RNA, Biochemistry, Nucleic acid, Oligonucleotide and Nuclease. His biological study deals with issues like Potency, which deal with fields such as Toxicity and Nucleotide. His study in the field of Gene expression, Ribosomal RNA and Internal ribosome entry site also crosses realms of Therapeutic gene modulation.
Eric E. Swayze combines subjects such as Molecular biology, Antisense RNA and RNase H with his study of Oligonucleotide. He has researched Nuclease in several fields, including Bicyclic molecule and Stereochemistry. His research integrates issues of Ring and Hepatitis C virus in his study of Stereochemistry.
His main research concerns Stereochemistry, RNA, Biochemistry, Nucleic acid and Oligonucleotide. His study looks at the relationship between Stereochemistry and fields such as Combinatorial chemistry, as well as how they intersect with chemical problems. Eric E. Swayze interconnects Double stranded and Cell biology in the investigation of issues within RNA.
His work on Nucleotide, Potency and Gene expression as part of his general Biochemistry study is frequently connected to Conjugate, thereby bridging the divide between different branches of science. His Nucleic acid research incorporates elements of Nucleoside analogue, DNA and Therapeutic index. His study on Oligonucleotide also encompasses disciplines like
His primary areas of study are Oligonucleotide, Pharmacology, In vivo, Messenger RNA and Cell biology. His Oligonucleotide research includes themes of Cleavage, Nucleobase, Biophysics, Sequence and Albumin. His Cell biology research includes elements of RNA, Gene and Gene isoform.
His biological study spans a wide range of topics, including Phosphate, Medicinal chemistry and Function. His research investigates the connection between Cancer research and topics such as Transthyretin that intersect with problems in Biochemistry. His work on Stereochemistry is being expanded to include thematically relevant topics such as Nuclease.
The scientist’s investigation covers issues in Plasma protein binding, Oligonucleotide, Pharmacology, Albumin and Blood proteins. Many of his studies involve connections with topics such as RNA and Plasma protein binding. His Oligonucleotide study combines topics in areas such as Biophysics, Cleavage and Protein–protein interaction.
His research in Biophysics intersects with topics in Nucleic acid, Glycoprotein and Nuclease. His Pharmacology study integrates concerns from other disciplines, such as Potency, Spinal muscular atrophy, Cell type and Mechanism of action. His Blood proteins course of study focuses on Cholesterol and Skeletal muscle, Cardiac muscle, Molecular biology and Myocyte.
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RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
C Frank Bennett;Eric E Swayze.
Annual Review of Pharmacology and Toxicology (2010)
Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.
Charles R. Allerson;Namir Sioufi;Russell Jarres;Thazha P. Prakash.
Journal of Medicinal Chemistry (2005)
Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
Eric E. Swayze;Andrew M. Siwkowski;Edward V. Wancewicz;Michael T. Migawa.
Nucleic Acids Research (2007)
Positional effect of chemical modifications on short interference RNA activity in mammalian cells.
Thazha P. Prakash;Charles R. Allerson;Prasad Dande;Timothy A. Vickers.
Journal of Medicinal Chemistry (2005)
6-modified bicyclic nucleic acid analogs
Eric E. Swayze;Punit P. Seth.
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
Swayze Eric E;Prakash Thazha P;Bhat Balkrishen.
5′-modified bicyclic nucleic acid analogs
Punit P. Seth;Eric E. Swayze.
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice
Thazha P. Prakash;Mark J. Graham;Jinghua Yu;Rick Carty.
Nucleic Acids Research (2014)
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
Charles Allerson;Balkrishen Bhat;Anne B. Eldrup;Muthiah Manoharan.
6-disubstituted bicyclic nucleic acid analogs
Seth Punit P;Swayze Eric E.
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