2026 Mark A. Behlke: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	73	1269	1131	652	568	205	21973

Overview

Mark A. Behlke is affiliated with Integrated DNA Technologies in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with significant contributions to molecular biology, immunology, oncology, genetics, and physiology. Their work is distributed across several relevant topics, including CRISPR and genetic engineering, RNA interference and gene delivery, immune cell function and interaction, advanced biosensing and bioanalysis techniques, CAR-T cell therapy research, immune response and inflammation, and erythrocyte function and pathophysiology.

Among their recent publications are notable papers that showcase a focus on genome editing technologies, immune modulation, and cell therapy development. These include:

CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy (2020) published in Science Advances
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells (2020) published in Blood
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicines (2021) published in Nature Communications
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells (2021) published in Nature Medicine
Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System (2020) published in Molecular Therapy - Methods & Clinical Development

Frequent co-authors who have collaborated with Behlke include Rolf Turk, Garrett R. Rettig, Matthew McNeill, Gavin Kurgan, and Mollie S. Schubert. This suggests active collaboration in interdisciplinary scientific teams.

Behlke's work has appeared in a range of scientific journals and venues, many of which are prominent in genetics, molecular therapy, and related biomedical fields. These include:

bioRxiv (Cold Spring Harbor Laboratory)
Molecular Therapy - Methods & Clinical Development
Nucleic Acids Research
Blood
Nature Communications

The main scientific topics addressed in Behlke's research emphasize gene editing technologies such as CRISPR, delivery systems for RNA interference, and immune cell functionalities. Other significant themes revolve around therapeutic development using cell and gene engineering, particularly in the context of oncology and hematopoietic diseases.

Best Publications

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

Dong-Ho Kim;Mark A Behlke;Scott D Rose;Mi-Sook Chang

1214
Citations
Identification of preexisting adaptive immunity to Cas9 proteins in humans

Carsten T. Charlesworth;Priyanka S. Deshpande;Daniel P. Dever;Joab Camarena

1023
Citations
Progress Toward In Vivo Use of siRNAs-II

Garrett R Rettig;Mark A Behlke

700
Citations
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.

Christopher A. Vakulskas;Daniel P. Dever;Garrett R. Rettig;Rolf Turk

682
Citations
Chemical Modification of siRNAs for In Vivo Use

Mark A. Behlke

579
Citations
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

Joao Trindade Marques;Thalie Devosse;Die Wang;Maryam Zamanian-Daryoush

506
Citations
Functional polarity is introduced by Dicer processing of short substrate RNAs

Scott D. Rose;Dong-Ho Kim;Mohammed Amarzguioui;Jeremy D. Heidel

504
Citations
Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

Michael P. Gantier;Claire E. McCoy;Irina Rusinova;Damien Saulep

501
Citations
Chemical modification and design of anti-miRNA oligonucleotides

K A Lennox;M A Behlke

498
Citations
Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Rolen M. Quadros;Hiromi Miura;Donald W. Harms;Hisako Akatsuka

467
Citations
Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides.

Kim A. Lennox;Mark A. Behlke

428
Citations
Murine T-cell receptor mutants with deletions of beta-chain variable region genes

Mark A. Behlke;Hubert S. Chou;Konrad Huppi;Dennis Y. Loh

418
Citations
Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures.

Richard Owczarzy;Yong You;Bernardo G Moreira;Jeffrey A Manthey

411
Citations
Predicting Stability of DNA Duplexes in Solutions Containing Magnesium and Monovalent Cations

Richard Owczarzy;Bernardo G. Moreira;Yong You;Mark A. Behlke

399
Citations
CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy

Daniel Rosenblum;Anna Gutkin;Ranit Kedmi;Srinivas Ramishetti

377
Citations
Hybridization kinetics and thermodynamics of molecular beacons

Andrew Tsourkas;Mark A. Behlke;Scott D. Rose;Gang Bao

373
Citations
Design of LNA probes that improve mismatch discrimination

Yong You;Bernardo G. Moreira;Mark A. Behlke;Richard Owczarzy

362
Citations
Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

Kenneth A Howard;Søren R Paludan;Mark A Behlke;Flemming Besenbacher

356
Citations
miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors

Tal Melkman-Zehavi;Roni Oren;Sharon Kredo-Russo;Tirosh Shapira

324
Citations
Oligonucleotide Therapies: The Past and the Present.

Karin E. Lundin;Olof Gissberg;C.I. Edvard Smith

311
Citations

Frequent Co-Authors

John J. Rossi City Of Hope National Medical Center

Paul B. McCray University of Iowa

Gang Bao Rice University

Matthew H. Porteus Stanford University

James O McNamara Duke University

Beverly L. Davidson Children's Hospital of Philadelphia

Dennis Y. Loh Washington University in St. Louis

Heng Li Harvard University

Samir El Andaloussi Karolinska Institute

Elizabeth J. Shpall The University of Texas MD Anderson Cancer Center

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