Matthew H. Porteus spends much of his time researching Gene targeting, Genetics, Genome editing, Zinc finger and Zinc finger nuclease. The various areas that he examines in his Gene targeting study include Mutation, Molecular biology, Stem cell and Chromatin. His Genetics research is multidisciplinary, incorporating perspectives in Computational biology and Cell biology.
His Genome editing research incorporates themes from Ribonucleoprotein and Cas9. His Zinc finger research includes elements of Transcription activator-like effector nuclease and Genome engineering. His work in the fields of Homologous recombination, Complementary DNA, Molecular cloning and DLX6 overlaps with other areas such as Melanogaster.
Matthew H. Porteus mostly deals with Genome editing, Genetics, Stem cell, Haematopoiesis and Cell biology. Matthew H. Porteus has researched Genome editing in several fields, including Computational biology and Homologous recombination. His work on Genetics deals in particular with Gene, Zinc finger nuclease, Genome engineering, Locus and Transcription factor.
His research integrates issues of Molecular biology, Cancer research, Genetic enhancement and Transplantation in his study of Stem cell. In his study, Bone marrow is strongly linked to Progenitor cell, which falls under the umbrella field of Haematopoiesis. His study looks at the relationship between Gene targeting and fields such as Zinc finger, as well as how they intersect with chemical problems.
His scientific interests lie mostly in Stem cell, Haematopoiesis, Cell biology, Cancer research and Gene. His biological study spans a wide range of topics, including Cystic fibrosis and CD19. His Haematopoiesis study combines topics in areas such as Progenitor cell and Glucocerebrosidase.
His Cell biology study incorporates themes from Genome editing and Phenotype. His studies in Genome editing integrate themes in fields like Cell and Disease. His Gene study frequently draws connections between related disciplines such as Molecular biology.
Matthew H. Porteus focuses on Stem cell, Cell biology, Cancer research, Induced pluripotent stem cell and Transplantation. The study incorporates disciplines such as Inflammation, T cell and Cytokine in addition to Stem cell. Matthew H. Porteus combines subjects such as Phenotype, Premovement neuronal activity and Cellular model with his study of Cell biology.
The concepts of his Cancer research study are interwoven with issues in Haematopoiesis, HEK 293 cells, Genetic enhancement, Monocyte and Chimeric antigen receptor. His Transplantation research includes themes of Genome editing, Cell and Bioinformatics. His Genome editing study is concerned with the field of Genome as a whole.
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Highly efficient endogenous human gene correction using designed zinc-finger nucleases
Fyodor D. Urnov;Jeffrey C. Miller;Ya-Li Lee;Christian M. Beausejour.
Chimeric Nucleases Stimulate Gene Targeting in Human Cells
Matthew H. Porteus;David Baltimore.
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
Ayal Hendel;Rasmus O Bak;Joseph T Clark;Andrew B Kennedy.
Nature Biotechnology (2015)
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.
Morgan L. Maeder;Stacey Thibodeau-Beganny;Anna Osiak;David A. Wright.
Molecular Cell (2008)
Gene targeting using zinc finger nucleases
Matthew H Porteus;Dana Carroll.
Nature Biotechnology (2005)
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Denes Hnisz;Abraham S. Weintraub;Daniel S. Day;Anne-Laure Valton.
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
A. Bulfone;L. Puelles;M. H. Porteus;M. A. Frohman.
The Journal of Neuroscience (1993)
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever;Rasmus O. Bak;Andreas Reinisch;Joab Camarena.
Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells.
Sundar Durai;Mala Mani;Karthikeyan Kandavelou;Joy Wu.
Nucleic Acids Research (2005)
Identification of preexisting adaptive immunity to Cas9 proteins in humans
Carsten T. Charlesworth;Priyanka S. Deshpande;Daniel P. Dever;Joab Camarena.
Nature Medicine (2019)
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