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Matthew H. Porteus

Matthew H. Porteus

D-Index & Metrics

Genetics

D-Index
74
Citations
28532
World Ranking
1939
National Ranking
889

Overview

Matthew H. Porteus is affiliated with Stanford University in the United States. Their research spans a broad range of topics primarily within medicine, biochemistry, genetics, and molecular biology. The main fields of study for Porteus include medicine with 153 publications and biochemistry, genetics and molecular biology with 151 publications. Their work further delves into key subfields such as molecular biology (116 publications), genetics (47), immunology (36), oncology (33), and hematology (26).

The primary topics covered in Porteus's research focus on genetic and cellular therapies. These include:

  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Hemoglobinopathies and Related Disorders
  • Cytomegalovirus and herpesvirus research
  • Hematopoietic Stem Cell Transplantation

Their frequent co-authors reflect ongoing collaborative work and include M. Kyle Cromer, Daniel P. Dever, Joab Camarena, Alice Bertaina, and Mara Pavel-Dinu, all contributing to multiple publications together.

Porteus has published extensively in several key venues focusing on biomedical research, with numerous papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory) - 24 publications
  • Blood - 18 publications
  • Nature Communications - 14 publications
  • Molecular Therapy - 7 publications
  • Transplantation and Cellular Therapy - 6 publications

Recent notable papers by Porteus illustrate their engagement with advanced genetic and cellular techniques and their applications in disease modeling and therapy development. These include:

  • Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells (2020, Nature Biotechnology)
  • Neuronal defects in a human cellular model of 22q11.2 deletion syndrome (2020, Nature Medicine)
  • Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder (2020, Cell Stem Cell)
  • Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease (2021, Science Translational Medicine)
  • CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells (2020, Science Advances)

Best Publications

  • Highly efficient endogenous human gene correction using designed zinc-finger nucleases

    Fyodor D. Urnov;Jeffrey C. Miller;Ya-Li Lee;Christian M. Beausejour

  • Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

    Ayal Hendel;Rasmus O Bak;Joseph T Clark;Andrew B Kennedy

  • Chimeric Nucleases Stimulate Gene Targeting in Human Cells

    Matthew H. Porteus;David Baltimore

  • Activation of proto-oncogenes by disruption of chromosome neighborhoods

    Denes Hnisz;Abraham S. Weintraub;Daniel S. Day;Anne-Laure Valton

  • Identification of preexisting adaptive immunity to Cas9 proteins in humans

    Carsten T. Charlesworth;Priyanka S. Deshpande;Daniel P. Dever;Joab Camarena

  • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

    Morgan L. Maeder;Stacey Thibodeau-Beganny;Anna Osiak;David A. Wright

  • CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

    Daniel P. Dever;Rasmus O. Bak;Andreas Reinisch;Joab Camarena

  • Gene targeting using zinc finger nucleases

    Matthew H Porteus;Dana Carroll

  • Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

    A. Bulfone;L. Puelles;M. H. Porteus;M. A. Frohman

  • Transplantation Outcomes for Severe Combined Immunodeficiency, 2000–2009

    Sung Yun Pai;Brent R. Logan;Linda M. Griffith;Rebecca H. Buckley

  • Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States

    Antonia Kwan;Roshini S. Abraham;Robert Currier;Amy Brower

  • A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells.

    Christopher A. Vakulskas;Daniel P. Dever;Garrett R. Rettig;Rolf Turk

  • An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

    Daniel E. Bauer;Sophia C. Kamran;Sophia C. Kamran;Samuel Lessard;Jian Xu;Jian Xu

  • Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells.

    Sundar Durai;Mala Mani;Karthikeyan Kandavelou;Joy Wu

  • Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

    Jizhong Zou;Morgan L. Maeder;Prashant Mali;Shondra M. Pruett-Miller

  • MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

    Girdhar G. Sharma;Sairei So;Arun Gupta;Rakesh Kumar;Rakesh Kumar

  • Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double‐strand breaks

    Patrick Ryan Potts;Matthew H Porteus;Hongtao Yu

  • Use of chimeric nucleases to stimulate gene targeting

    David Baltimore;Matthew Porteus

  • Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells.

    Yuki Miura;Min-Yin Li;Fikri Birey;Kazuya Ikeda

  • Activation of proto-oncogenes by disruption of chromosome neighborhoods

    D. Hnisz;D. S. Day;A.-L. Valton;R. O. Bak

Frequent Co-Authors

Gang Bao
Gang Bao Rice University
Kenneth I. Weinberg
Kenneth I. Weinberg Stanford University
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
John L.R. Rubenstein
John L.R. Rubenstein University of California, San Francisco
Fulvio Mavilio
Fulvio Mavilio University of Modena and Reggio Emilia
Maria Grazia Roncarolo
Maria Grazia Roncarolo Stanford University
Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Harry L. Malech
Harry L. Malech National Institutes of Health
J. Keith Joung
J. Keith Joung Harvard University
Hans Peter Kiem
Hans Peter Kiem Fred Hutchinson Cancer Research Center

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Related Online Degrees & Career Pathways

Exploring genetics can lead to a wide range of healthcare and science-based career opportunities. Many students choose related fields such as medical coding, nursing, or healthcare administration. For example, becoming certified in medical coder certification is a popular option for those interested in managing patient records and working in health information.

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For cost-conscious students, accredited programs in healthcare management are accessible via healthcare administration degree online accredited pathways. These degrees can open doors to behind-the-scenes leadership positions in clinics, hospitals, and research organizations, complementing the scientific foundation gained through genetics studies.

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