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Genetics

D-Index
63
Citations
31132
World Ranking
2829
National Ranking
1238

Overview

Edward J. Rebar is affiliated with Sangamo BioSciences in the United States, focusing on research intersecting medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. Their work contributes to several main fields of study, including medicine (8 publications), biochemistry, genetics and molecular biology (6 publications), and immunology and microbiology (5 publications).

The scientist's research spans multiple subfields such as oncology, immunology, molecular biology, genetics, and physiology. Their main research topics cover CAR-T cell therapy, viral infectious diseases and gene expression in insects, immunotherapy and immune responses, virus-based gene therapy, immune cell function and interaction, as well as Alzheimer's disease research and neuroinflammation mechanisms.

Frequent publication venues where Edward J. Rebar has contributed include Blood, hosting 4 publications, Cancer Research with 2 publications, and Science Advances with 1 publication.

  • Persistent repression of tau in the brain using engineered zinc finger protein transcription factors (2021), published in Science Advances
  • Abstract LB144: Overexpression of CD47 protects hypoimmune CAR T cells from innate immune cell killing (2021), published in Cancer Research
  • Engineered Hypoimmune Allogeneic CAR T Cells Exhibit Innate and Adaptive Immune Evasion Even after Sensitization in Humanized Mice and Retain Potent Anti-Tumor Activity (2021), published in Blood
  • Enabling Potent T Cell Delivery and Mitigating Key Off-Target Concerns of In Vivo CAR T Lentiviral Vectors with the Targeted Paramyxovirus Fusogen System (2024), published in Blood
  • Efficient and Specific Multi-Locus Editing of Allogeneic CAR T Cells for Hypoimmunity during Large Scale Manufacture Using Cas12b (2022), published in Blood

Frequent collaborators include Eleonore Tham, William E. Dowdle, Terry J. Fry, Xiaomeng Hu, and Kathy White, with repeated joint publications demonstrating sustained partnerships in the research community.

Best Publications

  • Genome editing with engineered zinc finger nucleases

    Fyodor D. Urnov;Edward J. Rebar;Michael C. Holmes;H. Steve Zhang

  • A TALE nuclease architecture for efficient genome editing

    Jeffrey C Miller;Siyuan Tan;Guijuan Qiao;Kyle A Barlow

  • Genetic engineering of human pluripotent cells using TALE nucleases

    Dirk Hockemeyer;Haoyi Wang;Samira Kiani;Christine S Lai

  • An improved zinc-finger nuclease architecture for highly specific genome editing

    Jeffrey C Miller;Michael C Holmes;Jianbin Wang;Dmitry Y Guschin

  • Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

    Elena E. Perez;Jianbin Wang;Jeffrey C. Miller;Yann Jouvenot;Yann Jouvenot

  • Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

    Dirk Hockemeyer;Frank Soldner;Caroline Beard;Qing Gao

  • Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

    Aron M. Geurts;Gregory J. Cost;Yevgeniy Freyvert;Bryan Zeitler

  • Precise genome modification in the crop species Zea mays using zinc-finger nucleases

    Vipula K. Shukla;Yannick Doyon;Jeffrey C. Miller;Russell C. DeKelver

  • Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

    Yannick Doyon;Jasmine M McCammon;Jeffrey C Miller;Farhoud Faraji

  • Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

    Frank Soldner;Josée Laganière;Albert W. Cheng;Dirk Hockemeyer

  • Targeted genome editing across species using ZFNs and TALENs.

    Andrew J. Wood;Te-Wen Lo;Bryan Zeitler;Catherine S. Pickle

  • In vivo genome editing restores haemostasis in a mouse model of haemophilia

    Hojun Li;Virginia Haurigot;Yannick Doyon;Tianjian Li

  • Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites

    Stephen P. Eisenberg;Casey C. Case;George N. Cox;Andrew Jamieson

  • A rapid and general assay for monitoring endogenous gene modification.

    Dmitry Guschin;Adam James Waite;Adam James Waite;George E. Katibah;Jeffrey C. Miller

  • A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.

    Hiroki Torikai;Andreas Reik;Pei Qi Liu;Yuanyue Zhou

  • PPARγ knockdown by engineered transcription factors: exogenous PPARγ2 but not PPARγ1 reactivates adipogenesis

    Delin Ren;Trevor N. Collingwood;Edward J. Rebar;Alan P. Wolffe

  • Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

    Yolanda Santiago;Edmond Chan;Pei-Qi Liu;Salvatore Orlando

  • Induction of angiogenesis in a mouse model using engineered transcription factors.

    Edward J. Rebar;Yan Huang;Reed Hickey;Anjali K. Nath

  • Translating dosage compensation to trisomy 21

    Jun Jiang;Yuanchun Jing;Gregory J. Cost;Jen Chieh Chiang

  • Genetic engineering of human ES and iPS cells using TALE nucleases

    Dirk Hockemeyer;Haoyi Wang;Samira Kiani;Christine S. Lai

Frequent Co-Authors

Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)
Fyodor D. Urnov
Fyodor D. Urnov University of California, Berkeley
Jeffrey C. Miller
Jeffrey C. Miller Sangamo BioSciences (United States)
Lei Zhang
Lei Zhang Sangamo BioSciences (United States)
Michael C. Holmes
Michael C. Holmes Ambys Medicines
Dirk Hockemeyer
Dirk Hockemeyer University of California, Berkeley
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Laurence J.N. Cooper
Laurence J.N. Cooper The University of Texas MD Anderson Cancer Center
Dean A. Lee
Dean A. Lee Nationwide Children's Hospital

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