World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
44
Citations
20753
World Ranking
19184
National Ranking
7831

Overview

Lei Zhang is affiliated with Sangamo BioSciences in the United States. Their research output spans several key fields including Biochemistry, Genetics and Molecular Biology, where they have contributed to 545 publications, and Medicine, with 486 publications. Within these broad areas, their work focuses notably on Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Surgery, and Oncology.

The scientist's research addresses multiple topics, highlighting a focus on cancer and molecular mechanisms. These include:

  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Extracellular vesicles in disease
  • RNA modifications and cancer
  • Ferroptosis and cancer prognosis
  • Epigenetics and DNA Methylation

Lei Zhang has been involved in publishing papers in several venues consistently, with frequent contributions to:

  • Research Square (Research Square)
  • Frontiers in Oncology
  • Scientific Reports
  • Frontiers in Immunology
  • PubMed

Some of the notable recent papers associated with Lei Zhang include:

  • "CNSA: a data repository for archiving omics data" (2020, Database)
  • "A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer" (2020, Molecular Cancer)
  • "FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2" (2022, Gut)
  • "A1 astrocytes contribute to murine depression-like behavior and cognitive dysfunction, which can be alleviated by IL-10 or fluorocitrate treatment" (2020, Journal of Neuroinflammation)
  • "Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer" (2021, Advanced Science)

Frequent co-authors working with Lei Zhang include:

  • Ming Chen (18 papers)
  • Guangyuan Zhang (14 papers)
  • Shuqiu Chen (13 papers)
  • Weipu Mao (12 papers)
  • Cristina R. Antonescu (8 papers)

Overall, Lei Zhang's work reflects strong interdisciplinary collaboration across molecular biology and cancer research domains, contributing to understanding molecular processes, disease regulation, and therapeutic strategies.

Best Publications

  • A TALE nuclease architecture for efficient genome editing

    Jeffrey C Miller;Siyuan Tan;Guijuan Qiao;Kyle A Barlow

  • Genetic engineering of human pluripotent cells using TALE nucleases

    Dirk Hockemeyer;Haoyi Wang;Samira Kiani;Christine S Lai

  • Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

    Dirk Hockemeyer;Frank Soldner;Caroline Beard;Qing Gao

  • Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

    Aron M. Geurts;Gregory J. Cost;Yevgeniy Freyvert;Bryan Zeitler

  • Precise genome modification in the crop species Zea mays using zinc-finger nucleases

    Vipula K. Shukla;Yannick Doyon;Jeffrey C. Miller;Russell C. DeKelver

  • Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

    Yannick Doyon;Jasmine M McCammon;Jeffrey C Miller;Farhoud Faraji

  • Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

    Frank Soldner;Josée Laganière;Albert W. Cheng;Dirk Hockemeyer

  • Targeted genome editing across species using ZFNs and TALENs.

    Andrew J. Wood;Te-Wen Lo;Bryan Zeitler;Catherine S. Pickle

  • K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

    Judith Straimer;Nina F. Gnädig;Benoit Witkowski;Chanaki Amaratunga

  • Knockout rats generated by embryo microinjection of TALENs

    Laurent Tesson;Laurent Tesson;Laurent Tesson;Claire Usal;Claire Usal;Claire Usal;Séverine Ménoret;Séverine Ménoret;Séverine Ménoret;Elo Leung

  • Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

    Elena Provasi;Pietro Genovese;Angelo Lombardo;Zulma Magnani

  • Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

    Janet Hauschild;Bjoern Petersen;Yolanda Santiago;Anna Lisa Queisser

  • Induction of angiogenesis in a mouse model using engineered transcription factors.

    Edward J. Rebar;Yan Huang;Reed Hickey;Anjali K. Nath

  • Methods and compositions for targeted cleavage and recombination

    Jeffrey C. Miller;Lei Zhang

  • Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

    Megan D. Hoban;Gregory J. Cost;Matthew C. Mendel;Zulema Romero

  • Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

    Russell C. DeKelver;Vivian M. Choi;Erica A. Moehle;David E. Paschon

  • DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation.

    Deniz Simsek;Erika Brunet;Erika Brunet;Sunnie Yan-Wai Wong;Sachin Katyal

  • Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene.

    Lei Zhang;S. Kaye Spratt;Qiang Liu;Brian Johnstone

  • Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

    Pei-Qi Liu;Edward J. Rebar;Lei Zhang;Qiang Liu

  • Functional genomics using zinc finger proteins

    Casey C. Case;Lei Zhang

Frequent Co-Authors

Edward J. Rebar
Edward J. Rebar Sangamo BioSciences (United States)
Philip D. Gregory
Philip D. Gregory Sangamo BioSciences (United States)
Fyodor D. Urnov
Fyodor D. Urnov University of California, Berkeley
Jeffrey C. Miller
Jeffrey C. Miller Sangamo BioSciences (United States)
Michael C. Holmes
Michael C. Holmes Ambys Medicines
Ignacio Anegon
Ignacio Anegon University of Nantes
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
David J. Tremethick
David J. Tremethick Australian National University
Abby F. Dernburg
Abby F. Dernburg University of California, Berkeley
Peter Koopman
Peter Koopman University of Queensland

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