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Rosalind A. Segal

Rosalind A. Segal

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
22130
World Ranking
8487
National Ranking
3816

Research.com Recognitions

  • 2006 - National Institutes of Health Director's Pioneer Award
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Rosalind A. Segal is affiliated with Harvard University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with extensive work in Molecular Biology, Cellular and Molecular Neuroscience, Oncology, Genetics, and Physiology.

Their research focuses on several key topics including Hedgehog Signaling Pathway Studies, Epigenetics and DNA Methylation, Glioma Diagnosis and Treatment, Cancer Treatment and Pharmacology, Chromatin Remodeling and Cancer, Axon Guidance and Neuronal Signaling, and Neuroinflammation and Neurodegeneration Mechanisms.

Frequent coauthors in their scientific publications include Maria F. Pazyra-Murphy, Yihang Li, Grace H. Hwang, Foteini Tsiami, and Ghazaleh Tabatabai.

Publications by this scientist have appeared often in several journals, notably Neuro-Oncology, bioRxiv (Cold Spring Harbor Laboratory), Developmental Cell, The Journal of Cell Biology, and Neuro-Oncology Advances.

Some of the recent published papers are:

  • Roadmap for the Emerging Field of Cancer Neuroscience, 2020, Cell
  • Diversity of developing peripheral glia revealed by single-cell RNA sequencing, 2021, Developmental Cell
  • Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival, 2020, The Journal of Cell Biology
  • Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN, 2021, The Journal of Cell Biology
  • TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system, 2023, Proceedings of the National Academy of Sciences

Rosalind A. Segal has received the National Institutes of Health Director's Pioneer Award in 2006 and is a Member of the Association of American Physicians.

Best Publications

  • Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

    Henryk Dudek;Sandeep Robert Datta;Thomas F. Franke;Morris J. Birnbaum

  • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

    Qing Ma;Dan Jones;Paul R. Borghesani;Rosalind A. Segal

  • Intracellular signaling pathways activated by neurotrophic factors.

    Rosalind A. Segal;Michael E. Greenberg

  • P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.

    Kevin C. Wang;Jieun A. Kim;Rajeev Sivasankaran;Rosalind Segal

  • A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors

    Joshua B. Rubin;Andrew L. Kung;Robyn S. Klein;Jennifer A. Chan

  • SELECTIVITY IN NEUROTROPHIN SIGNALING: Theme and Variations

    Rosalind A Segal

  • Neurotrophins use the Erk5 pathway to mediate a retrograde survival response

    Fiona L. Watson;Heather M. Heerssen;Anita Bhattacharyya;Laura Klesse

  • Abnormal Cerebellar Development and Foliation in BDNF−/− Mice Reveals a Role for Neurotrophins in CNS Patterning

    Phillip M Schwartz;Paul R Borghesani;Richard L Levy;Scott L Pomeroy

  • Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation.

    Yan-zhen Zhang;Daniel B. Moheban;Bevil R. Conway;Anita Bhattacharyya

  • Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns

    Robert J Cabelli;David L Shelton;Rosalind A Segal;Carla J Shatz

  • Retrograde neurotrophin signaling: Trk-ing along the axon

    David D Ginty;Rosalind A Segal

  • Studies on intercellular LETS glycoprotein matrices

    Lan Bo Chen;Andrew Murray;Rosalind A. Segal;Anne Bushnell

  • SDF-1α induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells

    Robyn S. Klein;Joshua B. Rubin;Hilary D. Gibson;Elliot N. DeHaan

  • Rapid Nuclear Responses to Target-Derived Neurotrophins Require Retrograde Transport of Ligand–Receptor Complex

    Fiona L. Watson;Heather M. Heerssen;Daniel B. Moheban;Michael Z. Lin

  • Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

    Ekaterina Pak;Rosalind A. Segal

  • Roadmap for the Emerging Field of Cancer Neuroscience

    Michelle Monje;Jeremy C. Borniger;Nisha J. D’Silva;Benjamin Deneen

  • BDNF stimulates migration of cerebellar granule cells

    Paul R. Borghesani;Jean Michel Peyrin;Robyn Klein;Joshua Rubin

  • Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

    Rosalind A. Segal;Liliana C. Goumnerova;Yunhee Kim Kwon;Charles D. Stiles

  • Changes in neurotrophin responsiveness during the development of cerebellar granule neurons.

    Rosalind A. Segal;Hiroshi Takahashi;Ronald D.G. McKay

  • Dynein motors transport activated Trks to promote survival of target-dependent neurons

    Heather M Heerssen;Maria F Pazyra;Rosalind A Segal

Frequent Co-Authors

Keith L. Ligon
Keith L. Ligon Harvard University
Charles D. Stiles
Charles D. Stiles Harvard University
Rameen Beroukhim
Rameen Beroukhim Harvard University
Mark W. Kieran
Mark W. Kieran Harvard University
Edna Mozes
Edna Mozes Weizmann Institute of Science
Scott L. Pomeroy
Scott L. Pomeroy Boston Children's Hospital
Jennifer A. Chan
Jennifer A. Chan University of Calgary
Michael E. Greenberg
Michael E. Greenberg Harvard University
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
Aviv Regev
Aviv Regev Genentech

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