World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
21633
World Ranking
12912
National Ranking
5499

Overview

Zhengui Xia is affiliated with the University of Washington in the United States and conducts research primarily in the fields of neuroscience and environmental science. Their work focuses on several subfields, including developmental neuroscience, health, toxicology and mutagenesis, molecular biology, cellular and molecular neuroscience, and pharmacology.

The research topics Zhengui Xia addresses cover a range of areas within neuroscience and toxicology. Key topics include:

  • Heavy Metal Exposure and Toxicity
  • Neurogenesis and neuroplasticity mechanisms
  • Anesthesia and Neurotoxicity Research
  • Gut microbiota and health
  • Neuroscience and Neuropharmacology Research
  • Cannabis and Cannabinoid Research
  • Olfactory and Sensory Function Studies

The scientist has contributed to multiple recent papers, highlighting their research on the neurological and systemic effects of cadmium exposure. Selected publications include:

  • "Adolescent cadmium exposure impairs cognition and hippocampal neurogenesis in C57BL/6 mice" (2021, Environmental Toxicology)
  • "Cadmium exposure modulates the gut-liver axis in an Alzheimer's disease mouse model" (2021, Communications Biology)
  • "Inducible and Conditional Stimulation of Adult Hippocampal Neurogenesis Rescues Cadmium-Induced Impairments of Adult Hippocampal Neurogenesis and Hippocampus-Dependent Memory in Mice" (2020, Toxicological Sciences)
  • "Inducible and conditional activation of ERK5 MAP kinase rescues mice from cadmium-induced olfactory memory deficits" (2020, NeuroToxicology)
  • "Effect of Chronic Cadmium Exposure on Brain and Liver Transporters and Drug-Metabolizing Enzymes in Male and Female Mice Genetically Predisposed to Alzheimer's Disease" (2022, Drug Metabolism and Disposition)

Publication venues where Zhengui Xia frequently publishes include Toxicological Sciences, Environmental Toxicology, Communications Biology, NeuroToxicology, and Drug Metabolism and Disposition.

The scientist's collaborative work involves frequent coauthors, among them:

  • Megumi Matsushita
  • Glen M. Abel
  • Julia Yue Cui
  • Daniel R. Storm
  • Hao Wang

Best Publications

  • Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

    Zhengui Xia;Martin Dickens;Joël Raingeaud;Roger J. Davis

  • Calcium Influx via the NMDA Receptor Induces Immediate Early Gene Transcription by a MAP Kinase/ERK-Dependent Mechanism

    Zhengui Xia;Henryk Dudek;Cindy K. Miranti;Michael E. Greenberg

  • A cytoplasmic inhibitor of the JNK signal transduction pathway

    Martin Dickens;Martin Dickens;Martin Dickens;Jeffrey Scott Rogers;Jeffrey Scott Rogers;Jeffrey Scott Rogers;Julie Cavanagh;Julie Cavanagh;Julie Cavanagh;Art Raitano;Art Raitano;Art Raitano

  • Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation.

    Jun Xing;Jon M. Kornhauser;Jon M. Kornhauser;Zhengui Xia;Zhengui Xia;Elizabeth A. Thiele;Elizabeth A. Thiele

  • Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase *

    Michal Hetman;Kevin Kanning;Jane E. Cavanaugh;Zhengui Xia

  • Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.

    Scott T. Wong;Kien Trinh;Beth Hacker;Guy C.K. Chan

  • The role of calmodulin as a signal integrator for synaptic plasticity

    Zhengui Xia;Daniel R. Storm

  • Role of Glycogen Synthase Kinase-3β in Neuronal Apoptosis Induced by Trophic Withdrawal

    Michal Hetman;Jane E. Cavanaugh;David Kimelman;Zhengui Xia

  • p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons

    Saadi Ghatan;Stephen Larner;Yoshito Kinoshita;Michal Hetman

  • ALTERED BEHAVIOR AND LONG-TERM POTENTIATION IN TYPE I ADENYLYL CYCLASE MUTANT MICE

    Zhi Liang Wu;Steven A. Thomas;Enrique C. Villacres;Zhengui Xia

  • CREB Transcriptional Activity in Neurons Is Regulated by Multiple, Calcium-Specific Phosphorylation Events

    Jon M. Kornhauser;Christopher W. Cowan;Adam J. Shaywitz;Ricardo E. Dolmetsch

  • Phosphorylation of cAMP Response Element-Binding Protein in Hippocampal Neurons as a Protective Response after Exposure to Glutamate In Vitro and Ischemia In Vivo

    Takuma Mabuchi;Kazuo Kitagawa;Keisuke Kuwabara;Kenichiro Takasawa

  • Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain : expression in areas associated with learning and memory

    Zhengui Xia;Cheryl D. Refsdal;Kalpana M. Merchant;Daniel M. Dorsa;Daniel M. Dorsa

  • Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP, or paraquat

    Won Seok Choi;Shane E. Kruse;Richard D. Palmiter;Zhengui Xia

  • Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin.

    Eui Ju Choi;Zhengui Xia;Daniel R. Storm

  • p38 MAP Kinase Mediates Apoptosis through Phosphorylation of BimEL at Ser-65

    Beibei Cai;Sandra H. Chang;Esther B.E. Becker;Azad Bonni

  • Chlorpyrifos Induces Apoptosis in Rat Cortical Neurons that is Regulated by a Balance Between p38 and ERK/JNK MAP Kinases

    Anne Caughlan;Kathleen Newhouse;Uk Namgung;Zhengui Xia

  • Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons

    Jane E. Cavanaugh;James Ham;Michal Hetman;Steve Poser

  • Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.

    Uk Namgung;Zhengui Xia

  • Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

    Won Seok Choi;Richard D. Palmiter;Zhengui Xia

Frequent Co-Authors

Daniel R. Storm
Daniel R. Storm University of Washington
Michal Hetman
Michal Hetman University of Louisville
Michael E. Greenberg
Michael E. Greenberg Harvard University
Richard D. Palmiter
Richard D. Palmiter University of Washington
Eui Ju Choi
Eui Ju Choi Korea University
Roger J. Davis
Roger J. Davis University of Massachusetts Chan Medical School
Hao Wang
Hao Wang Southeast University
Charles L. Sawyers
Charles L. Sawyers Memorial Sloan Kettering Cancer Center
Hiroyuki Sakagami
Hiroyuki Sakagami Kitasato University
Nobuyo Maeda
Nobuyo Maeda University of North Carolina at Chapel Hill

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