Thomas Herdegen

Best Publications

• JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system.

  Kirsten Mielke;Thomas Herdegen

  722
  Citations

• The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration

  Thomas Herdegen;Pate Skene;Mathias Bähr

  658
  Citations

• CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons.

  Ana Martin-Villalba;Ingrid Herr;Irmela Jeremias;Michael Hahne

  608
  Citations

• Specific temporal and spatial distribution of JUN, FOS, and KROX-24 proteins in spinal neurons following noxious transsynaptic stimulation.

  Thomas Herdegen;Karla Kovary;John Leah;Rodrigo Bravo

  487
  Citations

• Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury

  Thomas Herdegen;Francois Xavier Claret;Tuula Kallunki;Ana Martin-Villalba

  426
  Citations

• c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia.

  Vicki Waetzig;Karen Czeloth;Ute Hidding;Kirsten Mielke

  387
  Citations

• Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process.

  J.D. Leah;T. Herdegen;R. Bravo

  342
  Citations

• The Angiotensin II Type 2 (AT2) Receptor Promotes Axonal Regeneration in the Optic Nerve of Adult Rats

  Ralph Lucius;Stefan Gallinat;Philip Rosenstiel;Thomas Herdegen

  310
  Citations

• Specific pathophysiological functions of JNK isoforms in the brain.

  Stephan Brecht;Rainer Kirchhof;Ansgar Chromik;Mette Willesen

  309
  Citations

• The transcription factors c-JUN, JUN D and CREB, but not FOS and KROX-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve.

  Thomas Herdegen;Carlos E. Fiallos-Estrada;Wolfgang Schmid;Rodrigo Bravo

  292
  Citations

• Miswiring the brain: Δ9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

  Giuseppe Tortoriello;Claudia V Morris;Alan Alpar;Janos Fuzik;Janos Fuzik

  266
  Citations

• Basal expression of the inducible transcription factors c-Jun, JunB, JunD, c-Fos, FosB, and Krox-24 in the adult rat brain.

  Thomas Herdegen;Karla Kovary;Anja Buhl;Rodrigo Bravo

  265
  Citations

• Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats

  Yi Zhao;Andreas Patzer;Thomas Herdegen;Peter Gohlke

  265
  Citations

• Blockade of central angiotensin AT(1) receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats

  Wen-Jie Dai;Alexandra Funk;Thomas Herdegen;Thomas Unger

  257
  Citations

• Long-lasting increase of nitric oxide synthase immunoreactivity, NADPH-diaphorase reaction and c-JUN co-expression in rat dorsal root ganglion neurons following sciatic nerve transection.

  C.E. Fiallos-Estrada;W. Kummer;B. Mayer;R. Bravo

  246
  Citations

• Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy

  T Herdegen;S Brecht;B Mayer;J Leah

  245
  Citations

• Context-specific inhibition of JNKs: overcoming the dilemma of protection and damage

  Vicki Waetzig;Thomas Herdegen

  241
  Citations

• JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures.

  T. Herdegen;J. Sandkühler;P. Gass;M. Kiessling

  225
  Citations

• PPAR-γ: therapeutic target for ischemic stroke

  Juraj Culman;Yi Zhao;Peter Gohlke;Thomas Herdegen

  211
  Citations

• Induction of immediate early gene encoded proteins in the rat hippocampus after bicuculline-induced seizures: Differential expression of KROX-24, FOS and JUN proteins

  P. Gass;T. Herdegen;R. Bravo;M. Kiessling

  209
  Citations